Tumor-associated mesenchymal stem-like cells provide extracellular signaling cue for invasiveness of glioblastoma cells

Eun Jung Lim, Yongjoon Suh, Ki Chun Yoo, Ji Hyun Lee, In Gyu Kim, Min Jung Kim, Jong Hee Chang, Seok Gu Kang, Su Jae Lee

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Hyaluronic acid (HA) is abundant in tumor microenvironment and closely associated with invasiveness of glioblastoma (GBM) cells. However, the cellular mechanism underlying HA-rich microenvironment in GBM remains unexplored. Here, we show that tumor-associated mesenchymal stem-like cells (tMSLCs) contribute to abundance of hyaluronic acid (HA) in tumor microenvironment through HA synthase-2 (HAS2) induction, and thereby enhances invasiveness of GBM cells. In an autocrine manner, C5a secreted by tMSLCs activated ERK MAPK for HAS2 induction in tMSLCs. Importantly, HA acted as a signaling ligand of its cognate receptor RHAMM for intracellular signaling activation underlying invasiveness of GBM cells. Taken together, our study suggests that tMSLCs contribute to HA-rich proinvasive ECM microenvironment in GBM.

Original languageEnglish
Pages (from-to)1438-1448
Number of pages11
JournalOncotarget
Volume8
Issue number1
DOIs
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Oncology

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  • Cite this

    Lim, E. J., Suh, Y., Yoo, K. C., Lee, J. H., Kim, I. G., Kim, M. J., Chang, J. H., Kang, S. G., & Lee, S. J. (2017). Tumor-associated mesenchymal stem-like cells provide extracellular signaling cue for invasiveness of glioblastoma cells. Oncotarget, 8(1), 1438-1448. https://doi.org/10.18632/oncotarget.13638