TY - JOUR
T1 - Tumor perfusion-related parameter of diffusion-weighted magnetic resonance imaging
T2 - Correlation with histological microvessel density
AU - Lee, Hye Jeong
AU - Rha, Sun Young
AU - Chung, Yong Eun
AU - Shim, Hyo Sub
AU - Kim, Young Jin
AU - Hur, Jin
AU - Hong, Yoo Jin
AU - Choi, Byoung Wook
PY - 2014/4
Y1 - 2014/4
N2 - Purpose We obtained intravoxel incoherent motion (IVIM) parameters through biexponential analysis on diffusion-weighted MR imaging (DWI) using multiple b values. Correlation was evaluated between these parameters and histological microvessel density (MVD) for the possibility of noninvasive evaluation of MVD with DWI. Methods Twenty-five nude mice with the HT29 colorectal cancer cells implanted were analyzed after undergoing DWI with multiple b values (0, 50, 100, 300, 500, 700, and 1000 s/mm2). Tissue diffusivity (Dt), pseudo-diffusion coefficient (Dp), and perfusion fraction (f p) were calculated using a biexponential analysis, and these parameters were correlated with MVD. The MVD was determined with the CD31 stain. For statistical analysis, Spearman's rank correlation was applied. Results The mean value and correlation coefficient with MVD for each IVIM parameter were as follows: Dt = 0.98 ± 0.06 × 10-3 mm 2/s with r = 0.139 (P = 0.508); Dp = 23.70 ± 7.94 × 10-3 mm2/s with r = 0.782 (P < 0.001); and fp = 15.58 ± 5.7% with r = 0.749 (P < 0.001). Dp and fp showed significant correlation with MVD, but Dt did not. Conclusion The IVIM parameters, Dp and fp, on DWI might be used in the noninvasive evaluation of MVD.
AB - Purpose We obtained intravoxel incoherent motion (IVIM) parameters through biexponential analysis on diffusion-weighted MR imaging (DWI) using multiple b values. Correlation was evaluated between these parameters and histological microvessel density (MVD) for the possibility of noninvasive evaluation of MVD with DWI. Methods Twenty-five nude mice with the HT29 colorectal cancer cells implanted were analyzed after undergoing DWI with multiple b values (0, 50, 100, 300, 500, 700, and 1000 s/mm2). Tissue diffusivity (Dt), pseudo-diffusion coefficient (Dp), and perfusion fraction (f p) were calculated using a biexponential analysis, and these parameters were correlated with MVD. The MVD was determined with the CD31 stain. For statistical analysis, Spearman's rank correlation was applied. Results The mean value and correlation coefficient with MVD for each IVIM parameter were as follows: Dt = 0.98 ± 0.06 × 10-3 mm 2/s with r = 0.139 (P = 0.508); Dp = 23.70 ± 7.94 × 10-3 mm2/s with r = 0.782 (P < 0.001); and fp = 15.58 ± 5.7% with r = 0.749 (P < 0.001). Dp and fp showed significant correlation with MVD, but Dt did not. Conclusion The IVIM parameters, Dp and fp, on DWI might be used in the noninvasive evaluation of MVD.
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U2 - 10.1002/mrm.24810
DO - 10.1002/mrm.24810
M3 - Article
C2 - 23798038
AN - SCOPUS:84896543081
VL - 71
SP - 1554
EP - 1558
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
SN - 0740-3194
IS - 4
ER -