TY - JOUR
T1 - Tumour size is related to the curability of signet ring cell early gastric cancer with endoscopic submucosal dissection
T2 - A retrospective single centre study
AU - Kim, Mi Na
AU - Kim, Hyun Ki
AU - Shim, Choong Nam
AU - Lee, Hyun Jik
AU - Lee, Hyuk
AU - Park, Jun Chul
AU - Shin, Sung Kwan
AU - Lee, Sang Kil
AU - Lee, Yong Chan
N1 - Publisher Copyright:
© 2014 Editrice Gastroenterologica Italiana S.r.l.
PY - 2014
Y1 - 2014
N2 - Background: Endoscopic submucosal dissection is applied in selected cases of signet ring cell early gastric cancer. However, factors related to curability of signet ring cell early gastric cancer with this method have not been fully evaluated. Our aim was to evaluate factors related to incomplete resection in signet ring cell early gastric cancer with endoscopic submucosal dissection. Methods: A retrospective analysis was performed on a total of 126 consecutive patients with signet ring cell early gastric cancer who had undergone endoscopic submucosal dissection at the Severance Hospital in Korea, between March 2007 and March 2012. The clinical outcomes were reviewed and factors related to incomplete resection were analysed. Results: Multivariate analysis showed that large tumour size was the only significant factor related to incomplete resection (. P=. 0.006; hazard ratio, 1.040; 95% confidence interval, 1.101-1.084). In addition, large tumour size was the only significant factor related to endoscopic size underestimation (. P<. 0.001; hazard ratio, 1.391; 95% confidence interval, 1.221-1.586). The rate of endoscopic size underestimation was significantly higher in tumours with a size ≥20. mm (. P<. 0.001). Conclusions: To improve the curability of signet ring cell early gastric cancer with endoscopic submucosal dissection, larger tumours (especially tumour with a size ≥20. mm) should be resected with a larger margin.
AB - Background: Endoscopic submucosal dissection is applied in selected cases of signet ring cell early gastric cancer. However, factors related to curability of signet ring cell early gastric cancer with this method have not been fully evaluated. Our aim was to evaluate factors related to incomplete resection in signet ring cell early gastric cancer with endoscopic submucosal dissection. Methods: A retrospective analysis was performed on a total of 126 consecutive patients with signet ring cell early gastric cancer who had undergone endoscopic submucosal dissection at the Severance Hospital in Korea, between March 2007 and March 2012. The clinical outcomes were reviewed and factors related to incomplete resection were analysed. Results: Multivariate analysis showed that large tumour size was the only significant factor related to incomplete resection (. P=. 0.006; hazard ratio, 1.040; 95% confidence interval, 1.101-1.084). In addition, large tumour size was the only significant factor related to endoscopic size underestimation (. P<. 0.001; hazard ratio, 1.391; 95% confidence interval, 1.221-1.586). The rate of endoscopic size underestimation was significantly higher in tumours with a size ≥20. mm (. P<. 0.001). Conclusions: To improve the curability of signet ring cell early gastric cancer with endoscopic submucosal dissection, larger tumours (especially tumour with a size ≥20. mm) should be resected with a larger margin.
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U2 - 10.1016/j.dld.2014.05.019
DO - 10.1016/j.dld.2014.05.019
M3 - Article
C2 - 24973115
AN - SCOPUS:84922218550
VL - 46
SP - 898
EP - 902
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
IS - 10
ER -
