Tumour size is related to the curability of signet ring cell early gastric cancer with endoscopic submucosal dissection: A retrospective single centre study

Mi Na Kim, Hyun Ki Kim, Choong Nam Shim, Hyun Jik Lee, Hyuk Lee, Jun Chul Park, Sung Kwan Shin, SangKil Lee, Yongchan Lee

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Endoscopic submucosal dissection is applied in selected cases of signet ring cell early gastric cancer. However, factors related to curability of signet ring cell early gastric cancer with this method have not been fully evaluated. Our aim was to evaluate factors related to incomplete resection in signet ring cell early gastric cancer with endoscopic submucosal dissection. Methods: A retrospective analysis was performed on a total of 126 consecutive patients with signet ring cell early gastric cancer who had undergone endoscopic submucosal dissection at the Severance Hospital in Korea, between March 2007 and March 2012. The clinical outcomes were reviewed and factors related to incomplete resection were analysed. Results: Multivariate analysis showed that large tumour size was the only significant factor related to incomplete resection (. P=. 0.006; hazard ratio, 1.040; 95% confidence interval, 1.101-1.084). In addition, large tumour size was the only significant factor related to endoscopic size underestimation (. P<. 0.001; hazard ratio, 1.391; 95% confidence interval, 1.221-1.586). The rate of endoscopic size underestimation was significantly higher in tumours with a size ≥20. mm (. P<. 0.001). Conclusions: To improve the curability of signet ring cell early gastric cancer with endoscopic submucosal dissection, larger tumours (especially tumour with a size ≥20. mm) should be resected with a larger margin.

Original languageEnglish
Pages (from-to)898-902
Number of pages5
JournalDigestive and Liver Disease
Volume46
Issue number10
DOIs
Publication statusPublished - 2014 Jan 1

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Stomach Neoplasms
Neoplasms
Confidence Intervals
Korea
Multivariate Analysis
Endoscopic Mucosal Resection

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Kim, Mi Na ; Kim, Hyun Ki ; Shim, Choong Nam ; Lee, Hyun Jik ; Lee, Hyuk ; Park, Jun Chul ; Shin, Sung Kwan ; Lee, SangKil ; Lee, Yongchan. / Tumour size is related to the curability of signet ring cell early gastric cancer with endoscopic submucosal dissection : A retrospective single centre study. In: Digestive and Liver Disease. 2014 ; Vol. 46, No. 10. pp. 898-902.
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abstract = "Background: Endoscopic submucosal dissection is applied in selected cases of signet ring cell early gastric cancer. However, factors related to curability of signet ring cell early gastric cancer with this method have not been fully evaluated. Our aim was to evaluate factors related to incomplete resection in signet ring cell early gastric cancer with endoscopic submucosal dissection. Methods: A retrospective analysis was performed on a total of 126 consecutive patients with signet ring cell early gastric cancer who had undergone endoscopic submucosal dissection at the Severance Hospital in Korea, between March 2007 and March 2012. The clinical outcomes were reviewed and factors related to incomplete resection were analysed. Results: Multivariate analysis showed that large tumour size was the only significant factor related to incomplete resection (. P=. 0.006; hazard ratio, 1.040; 95{\%} confidence interval, 1.101-1.084). In addition, large tumour size was the only significant factor related to endoscopic size underestimation (. P<. 0.001; hazard ratio, 1.391; 95{\%} confidence interval, 1.221-1.586). The rate of endoscopic size underestimation was significantly higher in tumours with a size ≥20. mm (. P<. 0.001). Conclusions: To improve the curability of signet ring cell early gastric cancer with endoscopic submucosal dissection, larger tumours (especially tumour with a size ≥20. mm) should be resected with a larger margin.",
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Tumour size is related to the curability of signet ring cell early gastric cancer with endoscopic submucosal dissection : A retrospective single centre study. / Kim, Mi Na; Kim, Hyun Ki; Shim, Choong Nam; Lee, Hyun Jik; Lee, Hyuk; Park, Jun Chul; Shin, Sung Kwan; Lee, SangKil; Lee, Yongchan.

In: Digestive and Liver Disease, Vol. 46, No. 10, 01.01.2014, p. 898-902.

Research output: Contribution to journalArticle

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T1 - Tumour size is related to the curability of signet ring cell early gastric cancer with endoscopic submucosal dissection

T2 - A retrospective single centre study

AU - Kim, Mi Na

AU - Kim, Hyun Ki

AU - Shim, Choong Nam

AU - Lee, Hyun Jik

AU - Lee, Hyuk

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AU - Shin, Sung Kwan

AU - Lee, SangKil

AU - Lee, Yongchan

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N2 - Background: Endoscopic submucosal dissection is applied in selected cases of signet ring cell early gastric cancer. However, factors related to curability of signet ring cell early gastric cancer with this method have not been fully evaluated. Our aim was to evaluate factors related to incomplete resection in signet ring cell early gastric cancer with endoscopic submucosal dissection. Methods: A retrospective analysis was performed on a total of 126 consecutive patients with signet ring cell early gastric cancer who had undergone endoscopic submucosal dissection at the Severance Hospital in Korea, between March 2007 and March 2012. The clinical outcomes were reviewed and factors related to incomplete resection were analysed. Results: Multivariate analysis showed that large tumour size was the only significant factor related to incomplete resection (. P=. 0.006; hazard ratio, 1.040; 95% confidence interval, 1.101-1.084). In addition, large tumour size was the only significant factor related to endoscopic size underestimation (. P<. 0.001; hazard ratio, 1.391; 95% confidence interval, 1.221-1.586). The rate of endoscopic size underestimation was significantly higher in tumours with a size ≥20. mm (. P<. 0.001). Conclusions: To improve the curability of signet ring cell early gastric cancer with endoscopic submucosal dissection, larger tumours (especially tumour with a size ≥20. mm) should be resected with a larger margin.

AB - Background: Endoscopic submucosal dissection is applied in selected cases of signet ring cell early gastric cancer. However, factors related to curability of signet ring cell early gastric cancer with this method have not been fully evaluated. Our aim was to evaluate factors related to incomplete resection in signet ring cell early gastric cancer with endoscopic submucosal dissection. Methods: A retrospective analysis was performed on a total of 126 consecutive patients with signet ring cell early gastric cancer who had undergone endoscopic submucosal dissection at the Severance Hospital in Korea, between March 2007 and March 2012. The clinical outcomes were reviewed and factors related to incomplete resection were analysed. Results: Multivariate analysis showed that large tumour size was the only significant factor related to incomplete resection (. P=. 0.006; hazard ratio, 1.040; 95% confidence interval, 1.101-1.084). In addition, large tumour size was the only significant factor related to endoscopic size underestimation (. P<. 0.001; hazard ratio, 1.391; 95% confidence interval, 1.221-1.586). The rate of endoscopic size underestimation was significantly higher in tumours with a size ≥20. mm (. P<. 0.001). Conclusions: To improve the curability of signet ring cell early gastric cancer with endoscopic submucosal dissection, larger tumours (especially tumour with a size ≥20. mm) should be resected with a larger margin.

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