Tunable bacterial agglutination and motility inhibition by self-assembled glyco-nanoribbons

Yong beom Lim, Somi Park, Eunji Lee, Ja Hyoung Ryu, You Rim Yoon, Tae Hyun Kim, Myongsoo Lee

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

We explored a method of controlling bacterial motility and agglutination by using self-assembled carbohydrate-coated β-sheet nanoribbons. To this aim, we synthesized triblock peptides that consist of a carbohydrate, a polyethylene glycol (PEG) spacer, and a β-sheet-forming peptide. An investigation into the effect of PEG-spacer length on the self-assembly of the tri-block peptides showed that the PEG should be of sufficiently length to stabilize the β-sheet nanoribbon structure. It was found that the stabilization of the nanoribbon led to stronger activity in bacterial motility inhibition and agglutination, thus suggesting that antibacterial activity can be controlled by the stabilization strategy. Furthermore, another level of control over bacterial motility and agglutination was attained by co-assembly of bacteria-specific and -nonspecific supramolecular building blocks. The nanoribbon specifically detected bacteria after the encapsulation of a fluorescent probe. Moreover, the detection sensitivity was enhanced by the formation of bacterial clusters. All these results suggest that the carbohydrate-coated β-sheet nanoribbons can be developed as promising agents for pathogen capture, inactivation, and detection, and that the activity can be controlled at will.

Original languageEnglish
Pages (from-to)1363-1369
Number of pages7
JournalChemistry - An Asian Journal
Volume2
Issue number11
DOIs
Publication statusPublished - 2007

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry

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