Tunable bacterial agglutination and motility inhibition by self-assembled glyco-nanoribbons

Yong-beom Lim, Somi Park, Eunji Lee, Ja Hyoung Ryu, You Rim Yoon, Tae Hyun Kim, Myongsoo Lee

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

We explored a method of controlling bacterial motility and agglutination by using self-assembled carbohydrate-coated β-sheet nanoribbons. To this aim, we synthesized triblock peptides that consist of a carbohydrate, a polyethylene glycol (PEG) spacer, and a β-sheet-forming peptide. An investigation into the effect of PEG-spacer length on the self-assembly of the tri-block peptides showed that the PEG should be of sufficiently length to stabilize the β-sheet nanoribbon structure. It was found that the stabilization of the nanoribbon led to stronger activity in bacterial motility inhibition and agglutination, thus suggesting that antibacterial activity can be controlled by the stabilization strategy. Furthermore, another level of control over bacterial motility and agglutination was attained by co-assembly of bacteria-specific and -nonspecific supramolecular building blocks. The nanoribbon specifically detected bacteria after the encapsulation of a fluorescent probe. Moreover, the detection sensitivity was enhanced by the formation of bacterial clusters. All these results suggest that the carbohydrate-coated β-sheet nanoribbons can be developed as promising agents for pathogen capture, inactivation, and detection, and that the activity can be controlled at will.

Original languageEnglish
Pages (from-to)1363-1369
Number of pages7
JournalChemistry - An Asian Journal
Volume2
Issue number11
DOIs
Publication statusPublished - 2007 Nov 15

Fingerprint

Carbon Nanotubes
Agglutination
Carbohydrates
Peptides
Bacteria
Stabilization
Pathogens
Fluorescent Dyes
Encapsulation
Self assembly

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry

Cite this

Lim, Yong-beom ; Park, Somi ; Lee, Eunji ; Ryu, Ja Hyoung ; Yoon, You Rim ; Kim, Tae Hyun ; Lee, Myongsoo. / Tunable bacterial agglutination and motility inhibition by self-assembled glyco-nanoribbons. In: Chemistry - An Asian Journal. 2007 ; Vol. 2, No. 11. pp. 1363-1369.
@article{e9cfa60f9b2f472a8d4020e97b8bbfd6,
title = "Tunable bacterial agglutination and motility inhibition by self-assembled glyco-nanoribbons",
abstract = "We explored a method of controlling bacterial motility and agglutination by using self-assembled carbohydrate-coated β-sheet nanoribbons. To this aim, we synthesized triblock peptides that consist of a carbohydrate, a polyethylene glycol (PEG) spacer, and a β-sheet-forming peptide. An investigation into the effect of PEG-spacer length on the self-assembly of the tri-block peptides showed that the PEG should be of sufficiently length to stabilize the β-sheet nanoribbon structure. It was found that the stabilization of the nanoribbon led to stronger activity in bacterial motility inhibition and agglutination, thus suggesting that antibacterial activity can be controlled by the stabilization strategy. Furthermore, another level of control over bacterial motility and agglutination was attained by co-assembly of bacteria-specific and -nonspecific supramolecular building blocks. The nanoribbon specifically detected bacteria after the encapsulation of a fluorescent probe. Moreover, the detection sensitivity was enhanced by the formation of bacterial clusters. All these results suggest that the carbohydrate-coated β-sheet nanoribbons can be developed as promising agents for pathogen capture, inactivation, and detection, and that the activity can be controlled at will.",
author = "Yong-beom Lim and Somi Park and Eunji Lee and Ryu, {Ja Hyoung} and Yoon, {You Rim} and Kim, {Tae Hyun} and Myongsoo Lee",
year = "2007",
month = "11",
day = "15",
doi = "10.1002/asia.200700163",
language = "English",
volume = "2",
pages = "1363--1369",
journal = "Chemistry - An Asian Journal",
issn = "1861-4728",
publisher = "John Wiley and Sons Ltd",
number = "11",

}

Tunable bacterial agglutination and motility inhibition by self-assembled glyco-nanoribbons. / Lim, Yong-beom; Park, Somi; Lee, Eunji; Ryu, Ja Hyoung; Yoon, You Rim; Kim, Tae Hyun; Lee, Myongsoo.

In: Chemistry - An Asian Journal, Vol. 2, No. 11, 15.11.2007, p. 1363-1369.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Tunable bacterial agglutination and motility inhibition by self-assembled glyco-nanoribbons

AU - Lim, Yong-beom

AU - Park, Somi

AU - Lee, Eunji

AU - Ryu, Ja Hyoung

AU - Yoon, You Rim

AU - Kim, Tae Hyun

AU - Lee, Myongsoo

PY - 2007/11/15

Y1 - 2007/11/15

N2 - We explored a method of controlling bacterial motility and agglutination by using self-assembled carbohydrate-coated β-sheet nanoribbons. To this aim, we synthesized triblock peptides that consist of a carbohydrate, a polyethylene glycol (PEG) spacer, and a β-sheet-forming peptide. An investigation into the effect of PEG-spacer length on the self-assembly of the tri-block peptides showed that the PEG should be of sufficiently length to stabilize the β-sheet nanoribbon structure. It was found that the stabilization of the nanoribbon led to stronger activity in bacterial motility inhibition and agglutination, thus suggesting that antibacterial activity can be controlled by the stabilization strategy. Furthermore, another level of control over bacterial motility and agglutination was attained by co-assembly of bacteria-specific and -nonspecific supramolecular building blocks. The nanoribbon specifically detected bacteria after the encapsulation of a fluorescent probe. Moreover, the detection sensitivity was enhanced by the formation of bacterial clusters. All these results suggest that the carbohydrate-coated β-sheet nanoribbons can be developed as promising agents for pathogen capture, inactivation, and detection, and that the activity can be controlled at will.

AB - We explored a method of controlling bacterial motility and agglutination by using self-assembled carbohydrate-coated β-sheet nanoribbons. To this aim, we synthesized triblock peptides that consist of a carbohydrate, a polyethylene glycol (PEG) spacer, and a β-sheet-forming peptide. An investigation into the effect of PEG-spacer length on the self-assembly of the tri-block peptides showed that the PEG should be of sufficiently length to stabilize the β-sheet nanoribbon structure. It was found that the stabilization of the nanoribbon led to stronger activity in bacterial motility inhibition and agglutination, thus suggesting that antibacterial activity can be controlled by the stabilization strategy. Furthermore, another level of control over bacterial motility and agglutination was attained by co-assembly of bacteria-specific and -nonspecific supramolecular building blocks. The nanoribbon specifically detected bacteria after the encapsulation of a fluorescent probe. Moreover, the detection sensitivity was enhanced by the formation of bacterial clusters. All these results suggest that the carbohydrate-coated β-sheet nanoribbons can be developed as promising agents for pathogen capture, inactivation, and detection, and that the activity can be controlled at will.

UR - http://www.scopus.com/inward/record.url?scp=35948988040&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35948988040&partnerID=8YFLogxK

U2 - 10.1002/asia.200700163

DO - 10.1002/asia.200700163

M3 - Article

C2 - 17849402

AN - SCOPUS:35948988040

VL - 2

SP - 1363

EP - 1369

JO - Chemistry - An Asian Journal

JF - Chemistry - An Asian Journal

SN - 1861-4728

IS - 11

ER -