Tunable growth factor release from nano-assembled starch multilayers

Younghyun Cho, Jong Bum Lee, Jinkee Hong

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We report the preparation and characterization of polysaccharide-based nano-assembled surface coatings. Chitosan and fibroblast growth factor-2 (FGF-2) were assembled with starch through electrostatic layer-by-layer assembly. The chitosan/starch/FGF-2/starch nano-assembly surface coatings were formed via sequential adsorption of positively-charged chitosan and FGF-2 aqueous solutions and negatively-charged starch, with the process monitored by a profilometer. SEM was used to investigate the surface morphology and growth of multilayer coatings as a function of the number of bilayers. In addition, annealing of the multilayer structure induced physical reorganization of the starch granules. The FGF-2 release profile could be controlled by altering the microstructure of the starch. We expect that this demonstration of starch-based controlled release of growth factor will offer a new route to nano-assembly of truly biocompatible starch-based controlled-release surface coatings.

Original languageEnglish
Pages (from-to)32-36
Number of pages5
JournalChemical Engineering Journal
Volume221
DOIs
Publication statusPublished - 2013 Apr 1

Fingerprint

Starch
starch
Intercellular Signaling Peptides and Proteins
Multilayers
Fibroblast Growth Factor 2
Fibroblasts
coating
Chitosan
Coatings
annealing
Polysaccharides
polysaccharide
Surface morphology
Electrostatics
microstructure
Demonstrations
aqueous solution
scanning electron microscopy
Annealing
adsorption

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Environmental Chemistry
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering

Cite this

@article{763ef0cb3f25479f960febe0fdda3cb9,
title = "Tunable growth factor release from nano-assembled starch multilayers",
abstract = "We report the preparation and characterization of polysaccharide-based nano-assembled surface coatings. Chitosan and fibroblast growth factor-2 (FGF-2) were assembled with starch through electrostatic layer-by-layer assembly. The chitosan/starch/FGF-2/starch nano-assembly surface coatings were formed via sequential adsorption of positively-charged chitosan and FGF-2 aqueous solutions and negatively-charged starch, with the process monitored by a profilometer. SEM was used to investigate the surface morphology and growth of multilayer coatings as a function of the number of bilayers. In addition, annealing of the multilayer structure induced physical reorganization of the starch granules. The FGF-2 release profile could be controlled by altering the microstructure of the starch. We expect that this demonstration of starch-based controlled release of growth factor will offer a new route to nano-assembly of truly biocompatible starch-based controlled-release surface coatings.",
author = "Younghyun Cho and Lee, {Jong Bum} and Jinkee Hong",
year = "2013",
month = "4",
day = "1",
doi = "10.1016/j.cej.2013.01.087",
language = "English",
volume = "221",
pages = "32--36",
journal = "Chemical Engineering Journal",
issn = "1385-8947",
publisher = "Elsevier",

}

Tunable growth factor release from nano-assembled starch multilayers. / Cho, Younghyun; Lee, Jong Bum; Hong, Jinkee.

In: Chemical Engineering Journal, Vol. 221, 01.04.2013, p. 32-36.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Tunable growth factor release from nano-assembled starch multilayers

AU - Cho, Younghyun

AU - Lee, Jong Bum

AU - Hong, Jinkee

PY - 2013/4/1

Y1 - 2013/4/1

N2 - We report the preparation and characterization of polysaccharide-based nano-assembled surface coatings. Chitosan and fibroblast growth factor-2 (FGF-2) were assembled with starch through electrostatic layer-by-layer assembly. The chitosan/starch/FGF-2/starch nano-assembly surface coatings were formed via sequential adsorption of positively-charged chitosan and FGF-2 aqueous solutions and negatively-charged starch, with the process monitored by a profilometer. SEM was used to investigate the surface morphology and growth of multilayer coatings as a function of the number of bilayers. In addition, annealing of the multilayer structure induced physical reorganization of the starch granules. The FGF-2 release profile could be controlled by altering the microstructure of the starch. We expect that this demonstration of starch-based controlled release of growth factor will offer a new route to nano-assembly of truly biocompatible starch-based controlled-release surface coatings.

AB - We report the preparation and characterization of polysaccharide-based nano-assembled surface coatings. Chitosan and fibroblast growth factor-2 (FGF-2) were assembled with starch through electrostatic layer-by-layer assembly. The chitosan/starch/FGF-2/starch nano-assembly surface coatings were formed via sequential adsorption of positively-charged chitosan and FGF-2 aqueous solutions and negatively-charged starch, with the process monitored by a profilometer. SEM was used to investigate the surface morphology and growth of multilayer coatings as a function of the number of bilayers. In addition, annealing of the multilayer structure induced physical reorganization of the starch granules. The FGF-2 release profile could be controlled by altering the microstructure of the starch. We expect that this demonstration of starch-based controlled release of growth factor will offer a new route to nano-assembly of truly biocompatible starch-based controlled-release surface coatings.

UR - http://www.scopus.com/inward/record.url?scp=84874434390&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874434390&partnerID=8YFLogxK

U2 - 10.1016/j.cej.2013.01.087

DO - 10.1016/j.cej.2013.01.087

M3 - Article

AN - SCOPUS:84874434390

VL - 221

SP - 32

EP - 36

JO - Chemical Engineering Journal

JF - Chemical Engineering Journal

SN - 1385-8947

ER -