Tunable growth factor release from nano-assembled starch multilayers

Younghyun Cho, Jong Bum Lee, Jinkee Hong

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We report the preparation and characterization of polysaccharide-based nano-assembled surface coatings. Chitosan and fibroblast growth factor-2 (FGF-2) were assembled with starch through electrostatic layer-by-layer assembly. The chitosan/starch/FGF-2/starch nano-assembly surface coatings were formed via sequential adsorption of positively-charged chitosan and FGF-2 aqueous solutions and negatively-charged starch, with the process monitored by a profilometer. SEM was used to investigate the surface morphology and growth of multilayer coatings as a function of the number of bilayers. In addition, annealing of the multilayer structure induced physical reorganization of the starch granules. The FGF-2 release profile could be controlled by altering the microstructure of the starch. We expect that this demonstration of starch-based controlled release of growth factor will offer a new route to nano-assembly of truly biocompatible starch-based controlled-release surface coatings.

Original languageEnglish
Pages (from-to)32-36
Number of pages5
JournalChemical Engineering Journal
Volume221
DOIs
Publication statusPublished - 2013 Apr 1

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Environmental Chemistry
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering

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