Two cases of cutaneous Rosai-Dorfman disease

Hye Jin Chung, Mi Ryung Roh, Min Geol Lee, Kee Yang Chung

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Rosai-Dorfman disease (RDD) or sinus histiocytosis with massive lymphadenopathy (SHML) is a benign, idiopathic histiocytic proliferative disorder affecting lymph nodes as well as extranodal sites. It is accompanied by fever, leukocytosis, elevated erythrocyte sedimentation rate, and polyclonal hypergammaglobulinemia. Although cutaneous involvement in RDD is common, a purely cutaneous disease is very rare. Histologic findings show characteristic large, pale, histiocytic cells exhibiting cytophagocytosis (emperipolesis). Immunohistochemically, these histiocytes are positive for S-100 protein and CD68, but negative for CD1a. The etiology is unknown, although it is thought to be a reactive disorder rather than neoplastic. We report two cases of Rosai-Dorfman disease showing involvement limited to the skin.

Original languageEnglish
Pages (from-to)464-468
Number of pages5
JournalKorean Journal of Dermatology
Volume42
Issue number4
Publication statusPublished - 2004 Apr 1

Fingerprint

Sinus Histiocytosis
Skin
Emperipolesis
Adjustment Disorders
Hypergammaglobulinemia
Cytophagocytosis
Histiocytes
S100 Proteins
Blood Sedimentation
Leukocytosis
Skin Diseases
Fever
Lymph Nodes

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Chung, Hye Jin ; Roh, Mi Ryung ; Lee, Min Geol ; Chung, Kee Yang. / Two cases of cutaneous Rosai-Dorfman disease. In: Korean Journal of Dermatology. 2004 ; Vol. 42, No. 4. pp. 464-468.
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abstract = "Rosai-Dorfman disease (RDD) or sinus histiocytosis with massive lymphadenopathy (SHML) is a benign, idiopathic histiocytic proliferative disorder affecting lymph nodes as well as extranodal sites. It is accompanied by fever, leukocytosis, elevated erythrocyte sedimentation rate, and polyclonal hypergammaglobulinemia. Although cutaneous involvement in RDD is common, a purely cutaneous disease is very rare. Histologic findings show characteristic large, pale, histiocytic cells exhibiting cytophagocytosis (emperipolesis). Immunohistochemically, these histiocytes are positive for S-100 protein and CD68, but negative for CD1a. The etiology is unknown, although it is thought to be a reactive disorder rather than neoplastic. We report two cases of Rosai-Dorfman disease showing involvement limited to the skin.",
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Chung, HJ, Roh, MR, Lee, MG & Chung, KY 2004, 'Two cases of cutaneous Rosai-Dorfman disease', Korean Journal of Dermatology, vol. 42, no. 4, pp. 464-468.

Two cases of cutaneous Rosai-Dorfman disease. / Chung, Hye Jin; Roh, Mi Ryung; Lee, Min Geol; Chung, Kee Yang.

In: Korean Journal of Dermatology, Vol. 42, No. 4, 01.04.2004, p. 464-468.

Research output: Contribution to journalArticle

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AB - Rosai-Dorfman disease (RDD) or sinus histiocytosis with massive lymphadenopathy (SHML) is a benign, idiopathic histiocytic proliferative disorder affecting lymph nodes as well as extranodal sites. It is accompanied by fever, leukocytosis, elevated erythrocyte sedimentation rate, and polyclonal hypergammaglobulinemia. Although cutaneous involvement in RDD is common, a purely cutaneous disease is very rare. Histologic findings show characteristic large, pale, histiocytic cells exhibiting cytophagocytosis (emperipolesis). Immunohistochemically, these histiocytes are positive for S-100 protein and CD68, but negative for CD1a. The etiology is unknown, although it is thought to be a reactive disorder rather than neoplastic. We report two cases of Rosai-Dorfman disease showing involvement limited to the skin.

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