Two cases of multidrug-resistant human immunodeficiency virus infection treated with atazanavir and lopinavir/ritonavir combination therapy

Heekyoung Choi, Jin Jeong Su, Sung Lee Han, Sik Chin Bum, Hoon Choi Suk, Hoon Han Sang, Soo Kim Myung, Oh Kim Chang, Yong Choi Jun, Goo Song Young, Myung Kim June

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Abstract

The combination of atazanavir (ATV) and lopinavir/ritonavir (LPV/RTV) with nucleoside reverse transcriptase inhibitors (NRTI) has been used as a salvage regimen for human immunodeficiency virus (HIV)-positive patients. In this paper, we discuss two cases of HIV-positive patients who had long histories of virological failure following a heavy treatment of antiretroviral drugs, but then achieved virological suppression with double-boosted protease inhibitor (PI) regimens. In patients with multiple genotypic resistance to PIs and NRTIs, virological suppression can be achieved with a combination of ATV plus LPV/RTV with an NRTI backbone. The two cases in this report suggest that a combination of ATV plus LPV/RTV could be a useful salvage regimen for the subset of HIV-positive patients with limited treatment options.

Original languageEnglish
Pages (from-to)737-739
Number of pages3
JournalJournal of Korean medical science
Volume23
Issue number4
DOIs
Publication statusPublished - 2008 Aug

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Choi, H., Su, J. J., Han, S. L., Bum, S. C., Suk, H. C., Sang, H. H., Myung, S. K., Chang, O. K., Jun, Y. C., Young, G. S., & June, M. K. (2008). Two cases of multidrug-resistant human immunodeficiency virus infection treated with atazanavir and lopinavir/ritonavir combination therapy. Journal of Korean medical science, 23(4), 737-739. https://doi.org/10.3346/jkms.2008.23.4.737