Two cases of refractory thrombocytopenia in systemic lupus erythematosus that responded to intravenous low-dose cyclophosphamide

Hee Jin Park, Mi il Kang, Yoon Kang, Soo jin Chung, Sang Won Lee, Yong Beom Park, Soo Kon Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Treatment of thrombocytopenia in systemic lupus erythematosus (SLE) is considered in cases of current bleeding, severe bruising, or a platelet count below 50,000/μL. Corticosteroid is the first choice of medication for inducing remission, and immunosuppressive agents can be added when thrombocytopenia is refractory to corticosteroid or recurs despite it. We presented two SLE patients with thrombocytopenia who successfully induced remission after intravenous administration of low-dose cyclophosphamide (CYC) (500 mg fixed dose, biweekly for 3 months), followed by azathioprine (AZA) or mycophenolate mofetil (MMF). Both patients developed severe thrombocytopenia in SLE that did not respond to pulsed methylprednisolone therapy, and started the intravenous low-dose CYC therapy. In case 1, the platelet count increased to 50,000/μL after the first CYC infusion, and remission was maintained with low dose prednisolone and AZA. The case 2 achieved remission after three cycles of CYC, and the remission continued with low dose prednisolone and MMF.

Original languageEnglish
Pages (from-to)472-475
Number of pages4
JournalJournal of Korean medical science
Volume28
Issue number3
DOIs
Publication statusPublished - 2013 Mar 1

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Thrombocytopenia
Systemic Lupus Erythematosus
Cyclophosphamide
Mycophenolic Acid
Azathioprine
Prednisolone
Platelet Count
Adrenal Cortex Hormones
Methylprednisolone
Immunosuppressive Agents
Intravenous Administration
Therapeutics
Hemorrhage

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Park, Hee Jin ; Kang, Mi il ; Kang, Yoon ; Chung, Soo jin ; Lee, Sang Won ; Park, Yong Beom ; Lee, Soo Kon. / Two cases of refractory thrombocytopenia in systemic lupus erythematosus that responded to intravenous low-dose cyclophosphamide. In: Journal of Korean medical science. 2013 ; Vol. 28, No. 3. pp. 472-475.
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Two cases of refractory thrombocytopenia in systemic lupus erythematosus that responded to intravenous low-dose cyclophosphamide. / Park, Hee Jin; Kang, Mi il; Kang, Yoon; Chung, Soo jin; Lee, Sang Won; Park, Yong Beom; Lee, Soo Kon.

In: Journal of Korean medical science, Vol. 28, No. 3, 01.03.2013, p. 472-475.

Research output: Contribution to journalArticle

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AU - Park, Yong Beom

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