Two designs with a multiplexed superluminescent diode for ultra-high-resolution spectral-domain polarization-sensitive optical coherence tomography (UHR-PS-OCT) are introduced. In the first design, a Wollaston prism separates orthogonal polarization states next to each other on one linescan camera; the other design uses a beam displacer to separate orthogonal states onto two lines of a linescan camera with multiple rows of detectors. The coherence lengths measured with the two systems were 3.6 µm and 2.9 µm (n = 1.38), respectively. Measurements were collected from the fovea of a healthy subject, a healthy subject with astigmatism, and a patient with central serous retinopathy (CSR). A single volumetric scan provides double pass retardance induced by the retinal nerve fiber layer birefringence (RNFL) and its birefringence, the cumulative double pass retardance induced by the Henle fiber layer, and the retardance that is induced by the retinal pigment epithelium–Bruch’s membrane complex. The high axial resolution in UHR-PS-OCT is particularly helpful for the measurements of thin retinal tissue, such as the RNFL in the fovea, where birefringence values of around 1◦/µm were found. Tilting of the retina due to a CSR or by off centering the imaging beam in the pupil causes an artificial increase in the double pass retardance induced by the RNFL and Henle fiber layer.
|Number of pages||14|
|Journal||Journal of the Optical Society of America A: Optics and Image Science, and Vision|
|Publication status||Published - 2022 Jul|
Bibliographical noteFunding Information:
Acknowledgment. B. C. and C. J. acknowledge funding through the Brain Pool Program from the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT. M. R. thanks the Ministry of Education Culture, Sports, Science, and Technology (MEXT) of Japan for his scholarship. J. C. L. thanks Consejo Nacional de Ciencia y Tecnologia (CONACYT), Mexico, for his fellowship. The authors thank Ernesto Garcia from National Instruments Japan (currently with Garcia-Ruiz Engineering) for the data acquisition code that was custom-written in LabVIEW. They also thank Sebastian Biezemans, who contributed to LabVIEW pre-processing code to mask and bit shift the 32-bit output of the Basler L301k camera into intensity data, separated per camera row.
© 2022 Optica Publishing Group
All Science Journal Classification (ASJC) codes
- Electronic, Optical and Magnetic Materials
- Atomic and Molecular Physics, and Optics
- Computer Vision and Pattern Recognition