Two new norlignans from the aerial parts of Pouzolzia sanguinea (Blume) Merr

Le Thi Hong Nhung, Pham Thi Mai Huong, Nguyen Tuan Anh, Bui Huu Tai, Nguyen Xuan Nhiem, Vu Van Doan, Nguyen Huy Hoang, Yohan Seo, Seung Hyun Kim, Phan Van Kiem

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Two new norlignans, pouzolignan N (1) and pouzolignan O (2), together with five known norlignans, pouzolignan F (3), pouzolignan G (4), pouzolignan H (5), pouzolignan L (6), and gnetifolin F (7) were isolated from the aerial parts of Pouzolzia sanguinea (Blume) Merr. Their chemical structures were elucidated via HR-ESI-MS and NMR spectroscopic methods. Absolute configurations at stereocenters were confirmed by comparisons of CD spectra with those of TD-DFT calculations. Compounds 1–6 exhibited chemical structures unique to Pouzolzia species. At a concentration of 30 µM, compounds 1–7 exhibited weak cytotoxic activity toward CAL27 and MDA-MB-231 cell lines (cell viability from 65.3 ± 0.86 to 98.8 ± 1.23%). They also inhibited anoctamin-1 activity with inhibitory rates from 8.1 ± 0.87 to 24.3 ± 1.41%.

Original languageEnglish
Pages (from-to)157-164
Number of pages8
JournalNatural Product Research
Issue number1
Publication statusPublished - 2021

Bibliographical note

Funding Information:
This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2016.30.

Publisher Copyright:
© 2020 Informa UK Limited, trading as Taylor & Francis Group.

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry


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