Abstract
Background: Dissolving microneedles (DMNs) have been used for skin restoration and wrinkle improvement. Although lipophilic compounds, for example, natural oils or ceramides, enrich the skin barrier, their delivery via DMNs is challenging because of DMN fabrication difficulties. Objectives: In the present study, we combined a topical formulation and a DMN patch to perform two-phase delivery comprising a lipophilic formulation and hydrophilic compound-loaded DMNs to improve skin barrier status and the efficacy of drug delivery. Methods: Horse oil-spread and adenosine-loaded DMN arrays were developed in a single patch (HOS-Ad-DMN patch). In vitro analysis was conducted to confirm the successful delivery of the compositions. Clinical assessments were conducted on the lateral canthus of 20 women to compare the efficacy of HOS-Ad-DMN patches with that of adenosine-loaded DMN patches (Ad-DMN patches). Results: Adenosine was delivered via the DMNs after skin penetration and horse oil was delivered successfully into the skin through the microchannels created by the Ad-DMNs. Compared with Ad-DMN patches, HOS-Ad-DMN patches significantly improved skin elasticity, hydration, dermal density, and wrinkles. No adverse events were observed. Conclusion: HOS-Ad-DMN patches are a safe and efficient system for skin restoration and wrinkle improvement.
| Original language | English |
|---|---|
| Pages (from-to) | 936-943 |
| Number of pages | 8 |
| Journal | Journal of Cosmetic Dermatology |
| Volume | 18 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2019 Jun 1 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Dermatology
Cite this
}
Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement. / Yang, Huisuk; Kim, Suyong; Jang, Mingyu; Kim, Hyeonjun; Lee, Seunghee; Kim, Youseong; Eom, Younghyon Andrew; Kang, Geonwoo; Chiang, Liching; Baek, Ji Hwoon; Ryu, Ja Hyun; Lee, Ye Eun; Koh, Jaesuk; Jung, Hyungil.
In: Journal of Cosmetic Dermatology, Vol. 18, No. 3, 01.06.2019, p. 936-943.Research output: Contribution to journal › Article
TY - JOUR
T1 - Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement
AU - Yang, Huisuk
AU - Kim, Suyong
AU - Jang, Mingyu
AU - Kim, Hyeonjun
AU - Lee, Seunghee
AU - Kim, Youseong
AU - Eom, Younghyon Andrew
AU - Kang, Geonwoo
AU - Chiang, Liching
AU - Baek, Ji Hwoon
AU - Ryu, Ja Hyun
AU - Lee, Ye Eun
AU - Koh, Jaesuk
AU - Jung, Hyungil
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Background: Dissolving microneedles (DMNs) have been used for skin restoration and wrinkle improvement. Although lipophilic compounds, for example, natural oils or ceramides, enrich the skin barrier, their delivery via DMNs is challenging because of DMN fabrication difficulties. Objectives: In the present study, we combined a topical formulation and a DMN patch to perform two-phase delivery comprising a lipophilic formulation and hydrophilic compound-loaded DMNs to improve skin barrier status and the efficacy of drug delivery. Methods: Horse oil-spread and adenosine-loaded DMN arrays were developed in a single patch (HOS-Ad-DMN patch). In vitro analysis was conducted to confirm the successful delivery of the compositions. Clinical assessments were conducted on the lateral canthus of 20 women to compare the efficacy of HOS-Ad-DMN patches with that of adenosine-loaded DMN patches (Ad-DMN patches). Results: Adenosine was delivered via the DMNs after skin penetration and horse oil was delivered successfully into the skin through the microchannels created by the Ad-DMNs. Compared with Ad-DMN patches, HOS-Ad-DMN patches significantly improved skin elasticity, hydration, dermal density, and wrinkles. No adverse events were observed. Conclusion: HOS-Ad-DMN patches are a safe and efficient system for skin restoration and wrinkle improvement.
AB - Background: Dissolving microneedles (DMNs) have been used for skin restoration and wrinkle improvement. Although lipophilic compounds, for example, natural oils or ceramides, enrich the skin barrier, their delivery via DMNs is challenging because of DMN fabrication difficulties. Objectives: In the present study, we combined a topical formulation and a DMN patch to perform two-phase delivery comprising a lipophilic formulation and hydrophilic compound-loaded DMNs to improve skin barrier status and the efficacy of drug delivery. Methods: Horse oil-spread and adenosine-loaded DMN arrays were developed in a single patch (HOS-Ad-DMN patch). In vitro analysis was conducted to confirm the successful delivery of the compositions. Clinical assessments were conducted on the lateral canthus of 20 women to compare the efficacy of HOS-Ad-DMN patches with that of adenosine-loaded DMN patches (Ad-DMN patches). Results: Adenosine was delivered via the DMNs after skin penetration and horse oil was delivered successfully into the skin through the microchannels created by the Ad-DMNs. Compared with Ad-DMN patches, HOS-Ad-DMN patches significantly improved skin elasticity, hydration, dermal density, and wrinkles. No adverse events were observed. Conclusion: HOS-Ad-DMN patches are a safe and efficient system for skin restoration and wrinkle improvement.
UR - http://www.scopus.com/inward/record.url?scp=85052808580&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85052808580&partnerID=8YFLogxK
U2 - 10.1111/jocd.12768
DO - 10.1111/jocd.12768
M3 - Article
C2 - 30160014
AN - SCOPUS:85052808580
VL - 18
SP - 936
EP - 943
JO - Journal of Cosmetic Dermatology
JF - Journal of Cosmetic Dermatology
SN - 1473-2130
IS - 3
ER -