Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement

Huisuk Yang, Suyong Kim, Mingyu Jang, Hyeonjun Kim, Seunghee Lee, Youseong Kim, Younghyon Andrew Eom, Geonwoo Kang, Liching Chiang, Ji Hwoon Baek, Ja Hyun Ryu, Ye Eun Lee, Jaesuk Koh, Hyungil Jung

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Dissolving microneedles (DMNs) have been used for skin restoration and wrinkle improvement. Although lipophilic compounds, for example, natural oils or ceramides, enrich the skin barrier, their delivery via DMNs is challenging because of DMN fabrication difficulties. Objectives: In the present study, we combined a topical formulation and a DMN patch to perform two-phase delivery comprising a lipophilic formulation and hydrophilic compound-loaded DMNs to improve skin barrier status and the efficacy of drug delivery. Methods: Horse oil-spread and adenosine-loaded DMN arrays were developed in a single patch (HOS-Ad-DMN patch). In vitro analysis was conducted to confirm the successful delivery of the compositions. Clinical assessments were conducted on the lateral canthus of 20 women to compare the efficacy of HOS-Ad-DMN patches with that of adenosine-loaded DMN patches (Ad-DMN patches). Results: Adenosine was delivered via the DMNs after skin penetration and horse oil was delivered successfully into the skin through the microchannels created by the Ad-DMNs. Compared with Ad-DMN patches, HOS-Ad-DMN patches significantly improved skin elasticity, hydration, dermal density, and wrinkles. No adverse events were observed. Conclusion: HOS-Ad-DMN patches are a safe and efficient system for skin restoration and wrinkle improvement.

Original languageEnglish
Pages (from-to)936-943
Number of pages8
JournalJournal of Cosmetic Dermatology
Volume18
Issue number3
DOIs
Publication statusPublished - 2019 Jun 1

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Adenosine
Horses
Oils
Skin
Lacrimal Apparatus
Ceramides
Elasticity
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Yang, Huisuk ; Kim, Suyong ; Jang, Mingyu ; Kim, Hyeonjun ; Lee, Seunghee ; Kim, Youseong ; Eom, Younghyon Andrew ; Kang, Geonwoo ; Chiang, Liching ; Baek, Ji Hwoon ; Ryu, Ja Hyun ; Lee, Ye Eun ; Koh, Jaesuk ; Jung, Hyungil. / Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement. In: Journal of Cosmetic Dermatology. 2019 ; Vol. 18, No. 3. pp. 936-943.
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title = "Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement",
abstract = "Background: Dissolving microneedles (DMNs) have been used for skin restoration and wrinkle improvement. Although lipophilic compounds, for example, natural oils or ceramides, enrich the skin barrier, their delivery via DMNs is challenging because of DMN fabrication difficulties. Objectives: In the present study, we combined a topical formulation and a DMN patch to perform two-phase delivery comprising a lipophilic formulation and hydrophilic compound-loaded DMNs to improve skin barrier status and the efficacy of drug delivery. Methods: Horse oil-spread and adenosine-loaded DMN arrays were developed in a single patch (HOS-Ad-DMN patch). In vitro analysis was conducted to confirm the successful delivery of the compositions. Clinical assessments were conducted on the lateral canthus of 20 women to compare the efficacy of HOS-Ad-DMN patches with that of adenosine-loaded DMN patches (Ad-DMN patches). Results: Adenosine was delivered via the DMNs after skin penetration and horse oil was delivered successfully into the skin through the microchannels created by the Ad-DMNs. Compared with Ad-DMN patches, HOS-Ad-DMN patches significantly improved skin elasticity, hydration, dermal density, and wrinkles. No adverse events were observed. Conclusion: HOS-Ad-DMN patches are a safe and efficient system for skin restoration and wrinkle improvement.",
author = "Huisuk Yang and Suyong Kim and Mingyu Jang and Hyeonjun Kim and Seunghee Lee and Youseong Kim and Eom, {Younghyon Andrew} and Geonwoo Kang and Liching Chiang and Baek, {Ji Hwoon} and Ryu, {Ja Hyun} and Lee, {Ye Eun} and Jaesuk Koh and Hyungil Jung",
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Yang, H, Kim, S, Jang, M, Kim, H, Lee, S, Kim, Y, Eom, YA, Kang, G, Chiang, L, Baek, JH, Ryu, JH, Lee, YE, Koh, J & Jung, H 2019, 'Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement', Journal of Cosmetic Dermatology, vol. 18, no. 3, pp. 936-943. https://doi.org/10.1111/jocd.12768

Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement. / Yang, Huisuk; Kim, Suyong; Jang, Mingyu; Kim, Hyeonjun; Lee, Seunghee; Kim, Youseong; Eom, Younghyon Andrew; Kang, Geonwoo; Chiang, Liching; Baek, Ji Hwoon; Ryu, Ja Hyun; Lee, Ye Eun; Koh, Jaesuk; Jung, Hyungil.

In: Journal of Cosmetic Dermatology, Vol. 18, No. 3, 01.06.2019, p. 936-943.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement

AU - Yang, Huisuk

AU - Kim, Suyong

AU - Jang, Mingyu

AU - Kim, Hyeonjun

AU - Lee, Seunghee

AU - Kim, Youseong

AU - Eom, Younghyon Andrew

AU - Kang, Geonwoo

AU - Chiang, Liching

AU - Baek, Ji Hwoon

AU - Ryu, Ja Hyun

AU - Lee, Ye Eun

AU - Koh, Jaesuk

AU - Jung, Hyungil

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Background: Dissolving microneedles (DMNs) have been used for skin restoration and wrinkle improvement. Although lipophilic compounds, for example, natural oils or ceramides, enrich the skin barrier, their delivery via DMNs is challenging because of DMN fabrication difficulties. Objectives: In the present study, we combined a topical formulation and a DMN patch to perform two-phase delivery comprising a lipophilic formulation and hydrophilic compound-loaded DMNs to improve skin barrier status and the efficacy of drug delivery. Methods: Horse oil-spread and adenosine-loaded DMN arrays were developed in a single patch (HOS-Ad-DMN patch). In vitro analysis was conducted to confirm the successful delivery of the compositions. Clinical assessments were conducted on the lateral canthus of 20 women to compare the efficacy of HOS-Ad-DMN patches with that of adenosine-loaded DMN patches (Ad-DMN patches). Results: Adenosine was delivered via the DMNs after skin penetration and horse oil was delivered successfully into the skin through the microchannels created by the Ad-DMNs. Compared with Ad-DMN patches, HOS-Ad-DMN patches significantly improved skin elasticity, hydration, dermal density, and wrinkles. No adverse events were observed. Conclusion: HOS-Ad-DMN patches are a safe and efficient system for skin restoration and wrinkle improvement.

AB - Background: Dissolving microneedles (DMNs) have been used for skin restoration and wrinkle improvement. Although lipophilic compounds, for example, natural oils or ceramides, enrich the skin barrier, their delivery via DMNs is challenging because of DMN fabrication difficulties. Objectives: In the present study, we combined a topical formulation and a DMN patch to perform two-phase delivery comprising a lipophilic formulation and hydrophilic compound-loaded DMNs to improve skin barrier status and the efficacy of drug delivery. Methods: Horse oil-spread and adenosine-loaded DMN arrays were developed in a single patch (HOS-Ad-DMN patch). In vitro analysis was conducted to confirm the successful delivery of the compositions. Clinical assessments were conducted on the lateral canthus of 20 women to compare the efficacy of HOS-Ad-DMN patches with that of adenosine-loaded DMN patches (Ad-DMN patches). Results: Adenosine was delivered via the DMNs after skin penetration and horse oil was delivered successfully into the skin through the microchannels created by the Ad-DMNs. Compared with Ad-DMN patches, HOS-Ad-DMN patches significantly improved skin elasticity, hydration, dermal density, and wrinkles. No adverse events were observed. Conclusion: HOS-Ad-DMN patches are a safe and efficient system for skin restoration and wrinkle improvement.

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