Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement

Huisuk Yang, Suyong Kim, Mingyu Jang, Hyeonjun Kim, Seunghee Lee, Youseong Kim, Younghyon Andrew Eom, Geonwoo Kang, Liching Chiang, Ji Hwoon Baek, Ja Hyun Ryu, Ye Eun Lee, Jaesuk Koh, Hyungil Jung

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Dissolving microneedles (DMNs) have been used for skin restoration and wrinkle improvement. Although lipophilic compounds, for example, natural oils or ceramides, enrich the skin barrier, their delivery via DMNs is challenging because of DMN fabrication difficulties. Objectives: In the present study, we combined a topical formulation and a DMN patch to perform two-phase delivery comprising a lipophilic formulation and hydrophilic compound-loaded DMNs to improve skin barrier status and the efficacy of drug delivery. Methods: Horse oil-spread and adenosine-loaded DMN arrays were developed in a single patch (HOS-Ad-DMN patch). In vitro analysis was conducted to confirm the successful delivery of the compositions. Clinical assessments were conducted on the lateral canthus of 20 women to compare the efficacy of HOS-Ad-DMN patches with that of adenosine-loaded DMN patches (Ad-DMN patches). Results: Adenosine was delivered via the DMNs after skin penetration and horse oil was delivered successfully into the skin through the microchannels created by the Ad-DMNs. Compared with Ad-DMN patches, HOS-Ad-DMN patches significantly improved skin elasticity, hydration, dermal density, and wrinkles. No adverse events were observed. Conclusion: HOS-Ad-DMN patches are a safe and efficient system for skin restoration and wrinkle improvement.

Original languageEnglish
Pages (from-to)936-943
Number of pages8
JournalJournal of Cosmetic Dermatology
Volume18
Issue number3
DOIs
Publication statusPublished - 2019 Jun

All Science Journal Classification (ASJC) codes

  • Dermatology

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    Yang, H., Kim, S., Jang, M., Kim, H., Lee, S., Kim, Y., Eom, Y. A., Kang, G., Chiang, L., Baek, J. H., Ryu, J. H., Lee, Y. E., Koh, J., & Jung, H. (2019). Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement. Journal of Cosmetic Dermatology, 18(3), 936-943. https://doi.org/10.1111/jocd.12768