Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement

Huisuk Yang; Suyong Kim; Mingyu Jang; Hyeonjun Kim; Seunghee Lee; Youseong Kim; Younghyon Andrew Eom; Geonwoo Kang; Liching Chiang; Ji Hwoon Baek; Ja Hyun Ryu; Ye Eun Lee; Jaesuk Koh; Hyungil Jung

doi:10.1111/jocd.12768

Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement

Huisuk Yang, Suyong Kim, Mingyu Jang, Hyeonjun Kim, Seunghee Lee, Youseong Kim, Younghyon Andrew Eom, Geonwoo Kang, Liching Chiang, Ji Hwoon Baek, Ja Hyun Ryu, Ye Eun Lee, Jaesuk Koh, Hyungil Jung

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Background: Dissolving microneedles (DMNs) have been used for skin restoration and wrinkle improvement. Although lipophilic compounds, for example, natural oils or ceramides, enrich the skin barrier, their delivery via DMNs is challenging because of DMN fabrication difficulties. Objectives: In the present study, we combined a topical formulation and a DMN patch to perform two-phase delivery comprising a lipophilic formulation and hydrophilic compound-loaded DMNs to improve skin barrier status and the efficacy of drug delivery. Methods: Horse oil-spread and adenosine-loaded DMN arrays were developed in a single patch (HOS-Ad-DMN patch). In vitro analysis was conducted to confirm the successful delivery of the compositions. Clinical assessments were conducted on the lateral canthus of 20 women to compare the efficacy of HOS-Ad-DMN patches with that of adenosine-loaded DMN patches (Ad-DMN patches). Results: Adenosine was delivered via the DMNs after skin penetration and horse oil was delivered successfully into the skin through the microchannels created by the Ad-DMNs. Compared with Ad-DMN patches, HOS-Ad-DMN patches significantly improved skin elasticity, hydration, dermal density, and wrinkles. No adverse events were observed. Conclusion: HOS-Ad-DMN patches are a safe and efficient system for skin restoration and wrinkle improvement.

Original language	English
Pages (from-to)	936-943
Number of pages	8
Journal	Journal of Cosmetic Dermatology
Volume	18
Issue number	3
DOIs	https://doi.org/10.1111/jocd.12768
Publication status	Published - 2019 Jun

Bibliographical note

Funding Information:
This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI16C0625), and by the R&D Program of MSIP/COMPA (2016K000225, Development of minimal pain multi‐micro lancets for one‐touch‐smart diagnostic sensor).

Publisher Copyright:
© 2018 Wiley Periodicals, Inc.

All Science Journal Classification (ASJC) codes

Dermatology

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10.1111/jocd.12768

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Yang, H., Kim, S., Jang, M., Kim, H., Lee, S., Kim, Y., Eom, Y. A., Kang, G., Chiang, L., Baek, J. H., Ryu, J. H., Lee, Y. E., Koh, J., & Jung, H. (2019). Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement. Journal of Cosmetic Dermatology, 18(3), 936-943. https://doi.org/10.1111/jocd.12768

Yang, Huisuk ; Kim, Suyong ; Jang, Mingyu ; Kim, Hyeonjun ; Lee, Seunghee ; Kim, Youseong ; Eom, Younghyon Andrew ; Kang, Geonwoo ; Chiang, Liching ; Baek, Ji Hwoon ; Ryu, Ja Hyun ; Lee, Ye Eun ; Koh, Jaesuk ; Jung, Hyungil. / Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement. In: Journal of Cosmetic Dermatology. 2019 ; Vol. 18, No. 3. pp. 936-943.

@article{63d983f291254fc9b9ec7a40ca41a203,

title = "Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement",

abstract = "Background: Dissolving microneedles (DMNs) have been used for skin restoration and wrinkle improvement. Although lipophilic compounds, for example, natural oils or ceramides, enrich the skin barrier, their delivery via DMNs is challenging because of DMN fabrication difficulties. Objectives: In the present study, we combined a topical formulation and a DMN patch to perform two-phase delivery comprising a lipophilic formulation and hydrophilic compound-loaded DMNs to improve skin barrier status and the efficacy of drug delivery. Methods: Horse oil-spread and adenosine-loaded DMN arrays were developed in a single patch (HOS-Ad-DMN patch). In vitro analysis was conducted to confirm the successful delivery of the compositions. Clinical assessments were conducted on the lateral canthus of 20 women to compare the efficacy of HOS-Ad-DMN patches with that of adenosine-loaded DMN patches (Ad-DMN patches). Results: Adenosine was delivered via the DMNs after skin penetration and horse oil was delivered successfully into the skin through the microchannels created by the Ad-DMNs. Compared with Ad-DMN patches, HOS-Ad-DMN patches significantly improved skin elasticity, hydration, dermal density, and wrinkles. No adverse events were observed. Conclusion: HOS-Ad-DMN patches are a safe and efficient system for skin restoration and wrinkle improvement.",

author = "Huisuk Yang and Suyong Kim and Mingyu Jang and Hyeonjun Kim and Seunghee Lee and Youseong Kim and Eom, {Younghyon Andrew} and Geonwoo Kang and Liching Chiang and Baek, {Ji Hwoon} and Ryu, {Ja Hyun} and Lee, {Ye Eun} and Jaesuk Koh and Hyungil Jung",

note = "Funding Information: This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI16C0625), and by the R&D Program of MSIP/COMPA (2016K000225, Development of minimal pain multi‐micro lancets for one‐touch‐smart diagnostic sensor). Publisher Copyright: {\textcopyright} 2018 Wiley Periodicals, Inc.",

year = "2019",

month = jun,

doi = "10.1111/jocd.12768",

language = "English",

volume = "18",

pages = "936--943",

journal = "Journal of Cosmetic Dermatology",

issn = "1473-2130",

publisher = "Wiley-Blackwell",

number = "3",

}

Yang, H, Kim, S, Jang, M, Kim, H, Lee, S, Kim, Y, Eom, YA, Kang, G, Chiang, L, Baek, JH, Ryu, JH, Lee, YE, Koh, J & Jung, H 2019, 'Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement', Journal of Cosmetic Dermatology, vol. 18, no. 3, pp. 936-943. https://doi.org/10.1111/jocd.12768

Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement. / Yang, Huisuk; Kim, Suyong; Jang, Mingyu; Kim, Hyeonjun; Lee, Seunghee; Kim, Youseong; Eom, Younghyon Andrew; Kang, Geonwoo; Chiang, Liching; Baek, Ji Hwoon; Ryu, Ja Hyun; Lee, Ye Eun; Koh, Jaesuk; Jung, Hyungil.

In: Journal of Cosmetic Dermatology, Vol. 18, No. 3, 06.2019, p. 936-943.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement

AU - Yang, Huisuk

AU - Kim, Suyong

AU - Jang, Mingyu

AU - Kim, Hyeonjun

AU - Lee, Seunghee

AU - Kim, Youseong

AU - Eom, Younghyon Andrew

AU - Kang, Geonwoo

AU - Chiang, Liching

AU - Baek, Ji Hwoon

AU - Ryu, Ja Hyun

AU - Lee, Ye Eun

AU - Koh, Jaesuk

AU - Jung, Hyungil

N1 - Funding Information: This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI16C0625), and by the R&D Program of MSIP/COMPA (2016K000225, Development of minimal pain multi‐micro lancets for one‐touch‐smart diagnostic sensor). Publisher Copyright: © 2018 Wiley Periodicals, Inc.

PY - 2019/6

Y1 - 2019/6

N2 - Background: Dissolving microneedles (DMNs) have been used for skin restoration and wrinkle improvement. Although lipophilic compounds, for example, natural oils or ceramides, enrich the skin barrier, their delivery via DMNs is challenging because of DMN fabrication difficulties. Objectives: In the present study, we combined a topical formulation and a DMN patch to perform two-phase delivery comprising a lipophilic formulation and hydrophilic compound-loaded DMNs to improve skin barrier status and the efficacy of drug delivery. Methods: Horse oil-spread and adenosine-loaded DMN arrays were developed in a single patch (HOS-Ad-DMN patch). In vitro analysis was conducted to confirm the successful delivery of the compositions. Clinical assessments were conducted on the lateral canthus of 20 women to compare the efficacy of HOS-Ad-DMN patches with that of adenosine-loaded DMN patches (Ad-DMN patches). Results: Adenosine was delivered via the DMNs after skin penetration and horse oil was delivered successfully into the skin through the microchannels created by the Ad-DMNs. Compared with Ad-DMN patches, HOS-Ad-DMN patches significantly improved skin elasticity, hydration, dermal density, and wrinkles. No adverse events were observed. Conclusion: HOS-Ad-DMN patches are a safe and efficient system for skin restoration and wrinkle improvement.

AB - Background: Dissolving microneedles (DMNs) have been used for skin restoration and wrinkle improvement. Although lipophilic compounds, for example, natural oils or ceramides, enrich the skin barrier, their delivery via DMNs is challenging because of DMN fabrication difficulties. Objectives: In the present study, we combined a topical formulation and a DMN patch to perform two-phase delivery comprising a lipophilic formulation and hydrophilic compound-loaded DMNs to improve skin barrier status and the efficacy of drug delivery. Methods: Horse oil-spread and adenosine-loaded DMN arrays were developed in a single patch (HOS-Ad-DMN patch). In vitro analysis was conducted to confirm the successful delivery of the compositions. Clinical assessments were conducted on the lateral canthus of 20 women to compare the efficacy of HOS-Ad-DMN patches with that of adenosine-loaded DMN patches (Ad-DMN patches). Results: Adenosine was delivered via the DMNs after skin penetration and horse oil was delivered successfully into the skin through the microchannels created by the Ad-DMNs. Compared with Ad-DMN patches, HOS-Ad-DMN patches significantly improved skin elasticity, hydration, dermal density, and wrinkles. No adverse events were observed. Conclusion: HOS-Ad-DMN patches are a safe and efficient system for skin restoration and wrinkle improvement.

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U2 - 10.1111/jocd.12768

DO - 10.1111/jocd.12768

M3 - Article

C2 - 30160014

AN - SCOPUS:85052808580

VL - 18

SP - 936

EP - 943

JO - Journal of Cosmetic Dermatology

JF - Journal of Cosmetic Dermatology

SN - 1473-2130

IS - 3

ER -

Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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