Sensorineural hearing loss (SNHL) is the most common sensory deficit worldwide, and it typically originates from the cochlea. Methods to visualize intracochlear cells in living people are currently lacking, limiting not only diagnostics but also therapies for SNHL. Two-photon fluorescence microscopy (TPFM) is a high-resolution optical imaging technique. Here we demonstrate that TPFM enables visualization of sensory cells and auditory nerve fibers in an unstained, non-decalcified adult human cochlea.
|Journal||Frontiers in Cellular Neuroscience|
|Publication status||Published - 2021 Aug 5|
Bibliographical noteFunding Information:
The authors are grateful for support from the Department of Defense National Defense Science and Engineering Graduate Fellowship (JI), the Lauer Tinnitus Research Center (KS), and the Bertarelli Program in Translational Neuroscience and Neuroengineering (KS).
© Copyright © 2021 Iyer, Seist, Moon and Stankovic.
All Science Journal Classification (ASJC) codes
- Cellular and Molecular Neuroscience