Two-photon optical properties of near-infrared dyes at 1.55 μm excitation

Mikhail Y. Berezin, Chun Zhan, Hyeran Lee, Chulmin Joo, Walter J. Akers, Siavash Yazdanfar, Samuel Achilefu

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27 Citations (Scopus)

Abstract

Two-photon (2P) optical properties of cyanine dyes were evaluated using a 2P fluorescence spectrophotometer with 1.55 μm excitation. We report the 2P characteristics of common NIR polymethine dyes, including their 2P action cross sections and the 2P excited fluorescence lifetime. One of the dyes, DTTC, showed the highest 2P action cross-section (∼103 ± 19 GM) and relatively high 2P excited fluorescence lifetime and can be used as a scaffold for the synthesis of 2P molecular imaging probes. The 2P action cross-section of DTTC and the lifetime were also highly sensitive to the solvent polarity, providing other additional parameters for its use in optical imaging and the mechanism for probing environmental factors. Overall, this study demonstrated the quantitative measurement of 2P properties of NIR dyes and established the foundation for designing molecular probes for 2P imaging applications in the NIR region.

Original languageEnglish
Pages (from-to)11530-11535
Number of pages6
JournalJournal of Physical Chemistry B
Volume115
Issue number39
DOIs
Publication statusPublished - 2011 Oct 6

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Materials Chemistry

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    Berezin, M. Y., Zhan, C., Lee, H., Joo, C., Akers, W. J., Yazdanfar, S., & Achilefu, S. (2011). Two-photon optical properties of near-infrared dyes at 1.55 μm excitation. Journal of Physical Chemistry B, 115(39), 11530-11535. https://doi.org/10.1021/jp207618e