Ultra-Low Cost, Facile Fabrication of Transparent Neural Electrode Array for Electrocorticography with Photoelectric Artifact-Free Optogenetics

Young Uk Cho, Ju Young Lee, Ui Jin Jeong, Sang Hoon Park, Se Lin Lim, Kyung Yeun Kim, Je Wu Jang, Jong Ho Park, Hyun Woo Kim, Hyogeun Shin, Hojeong Jeon, Young Mee Jung, Il Joo Cho, Ki Jun Yu

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Transparent implantable devices have received significant attention in neuroscience and biomedical engineering by combining neural recording and optical modalities. Opaque, metal-based electrode arrays for electrophysiology block optical imaging and cause photoelectric artifacts, making them difficult to integrate with optogenetics. Here, a photoelectric artifact-free, highly conductive, and transparent poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) electrode array is introduced as promising neural implants. The technology which is developed in this work provides transparent neural interfaces through low-cost, ultra-facile method compared with other transparent materials being applied to implantable tools. The device exhibits superior optical, mechanical, and electrical characteristics to other studies, thanks to a simple ethylene glycol immersing process. The device performance is highlighted by comparing its light stimulation efficiency and photoelectric artifact extent with conventional thin gold electrodes both in vitro and in vivo. This platform can assemble transparent neural interfaces much more efficiently than any other material candidates and thus has many potential applications.

Original languageEnglish
Article number2105568
JournalAdvanced Functional Materials
Issue number10
Publication statusPublished - 2022 Mar 2

Bibliographical note

Funding Information:
This work acknowledges the support received from National Research Foundation of Korea (Grant no: NRF‐2019R1A2C2086085) and Brain Convergence Research Program of the National Research Foundation (NRF) funded by the Korean government (MSIT) (Grant no: NRF‐ 2019M3E5D2A01063814).

Publisher Copyright:
© 2021 The Authors. Advanced Functional Materials published by Wiley-VCH GmbH.

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics


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