Ultra-sensitive surface plasmon resonance detection by colocalized 3D plasmonic nanogap arrays

Wonju Lee, Taehwang Son, Changhun Lee, Yongjin Oh, Donghyun Kim

Research output: Chapter in Book/Report/Conference proceedingChapter

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Abstract

Ultra-sensitive detection based on surface plasmon resonance (SPR) was investigated using 3D nanogap arrays for colocalization of target molecular distribution and localized plasmon wave in the near-field. Colocalization was performed by oblique deposition of a dielectric mask layer to create nanogap at the side of circular and triangular nanoaperture, where fields localized by surface plasmon localization coincide with the spatial distribution of target molecular interactions. The feasibility of ultra-sensitivity was experimentally verified by measuring DNA hybridization. Triangular nanopattern provided an optimum to achieve highly amplified angular shifts and led to enhanced detection sensitivity on the order of 1 fg/mm2 in terms of molecular binding capacity.We confirmed improvement of SPR sensitivity by three orders of magnitude, compared with conventional SPR sensors, using 3D plasmonic nanogap arrays.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages15-29
Number of pages15
DOIs
Publication statusPublished - 2017 Jan 1

Publication series

NameMethods in Molecular Biology
Volume1571
ISSN (Print)1064-3745

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All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics

Cite this

Lee, W., Son, T., Lee, C., Oh, Y., & Kim, D. (2017). Ultra-sensitive surface plasmon resonance detection by colocalized 3D plasmonic nanogap arrays. In Methods in Molecular Biology (pp. 15-29). (Methods in Molecular Biology; Vol. 1571). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-6848-0_2