Ultrafast Electrochemical Trigger Drug Delivery Mechanism for Nanographene Micromachines

Bahareh Khezri, Seyyed Mohsen Beladi Mousavi, Ludmila Krejčová, Zbyněk Heger, Zdeněk Sofer, Martin Pumera

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Nano/micromachines with autonomous motion are the frontier of nanotechnology and nanomaterial research. These self-propelled nano/micromachines convert chemical energy obtained from their surroundings to propulsion. They have shown great potential in diagnostic and therapeutic applications. This work introduces a high-speed tubular electrically conductive micromachine based on reduced nanographene oxide (n-rGO) as a platform for drug delivery and platinum (Pt) as the catalytic inner layer. n-rGO/Pt micromachines are loaded with doxorubicin (DOX) by a simple physical adsorption with a very high loading efficiency, displaying single- or multistrand wrapping of DOX monomers on the micromachine cylinders. More importantly, it is found that electron injection into DOX@n-rGO/Pt micromachines via electrochemistry leads to expulsion of DOX from micromachines in motion within only a few seconds. An in vitro study confirms this efficient release mechanism in the presence of cancerous cells. The unique properties of the n-rGO/Pt micromotor enable the effective management of DOX release at the tumor site and thus enhances the therapeutic efficiency and reduces the side toxicity toward the healthy tissue. These micromachine drug carriers combine the high loading capacity of conventional carbon-based drug carriers with a fast and efficient electrochemical drug-release mechanism.

Original languageEnglish
Article number1806696
JournalAdvanced Functional Materials
Volume29
Issue number4
DOIs
Publication statusPublished - 2019 Jan 24

Fingerprint

Drug delivery
Doxorubicin
Platinum
delivery
drugs
platinum
actuators
Drug Carriers
micromotors
Micromotors
chemical energy
Electron injection
expulsion
Electrochemistry
electrochemistry
nanotechnology
propulsion
Nanotechnology
Nanostructured materials
toxicity

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Khezri, Bahareh ; Beladi Mousavi, Seyyed Mohsen ; Krejčová, Ludmila ; Heger, Zbyněk ; Sofer, Zdeněk ; Pumera, Martin. / Ultrafast Electrochemical Trigger Drug Delivery Mechanism for Nanographene Micromachines. In: Advanced Functional Materials. 2019 ; Vol. 29, No. 4.
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Ultrafast Electrochemical Trigger Drug Delivery Mechanism for Nanographene Micromachines. / Khezri, Bahareh; Beladi Mousavi, Seyyed Mohsen; Krejčová, Ludmila; Heger, Zbyněk; Sofer, Zdeněk; Pumera, Martin.

In: Advanced Functional Materials, Vol. 29, No. 4, 1806696, 24.01.2019.

Research output: Contribution to journalArticle

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