@inproceedings{7b6383b3534943edaa01a660561ed909,
title = "Ultrasensitive colocalization detection based on plasmonic nanolithography with molecular-overlapped optical near-fields",
abstract = "The detection sensitivity of surface plasmon resonance (SPR) biosensors has been improved by employing colocalization of spatial distribution of electromagnetic near-fields and detection molecules. We have used plasmon nanolithography to achieve light-matter colocalization on triangular nanoaperture arrays and optimized array configurations to improve colocalization efficiency. Streptavidin-biotin interactions were measured to validate the concept. It was confirmed that colocalized distributions of target binding and localized near-fields produced larger optical detection sensitivity. The colocalized detection was also shown to come with wider dynamic range than noncolocalized detection. The effective limit-of-detection of colocalized measurements was on the order of 30 pM. The colocalized detection sensitivity was estimated to be below 1 fg/mm2 in a 100-nm deep evanescent area, an enhancement by more than three orders of magnitude over conventional SPR sensor.",
author = "Kiheung Kim and Wonju Lee and Kyungwha Chung and Hongki Lee and Taehwang Son and Youngjin Oh and Xiao, {Yun Feng} and Kim, {Dong Ha} and Donghyun Kim",
year = "2018",
month = jan,
day = "1",
doi = "10.1117/12.2291449",
language = "English",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Nicolau, {Dan V.} and Cartwright, {Alexander N.} and Dror Fixler",
booktitle = "Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XV",
address = "United States",
note = "Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XV 2018 ; Conference date: 30-01-2018 Through 31-01-2018",
}