Ultrasensitive detection and risk assessment of di(2-ethylhexyl) phthalate migrated from daily-use plastic products using a nanostructured electrochemical aptasensor

Kyungyeon Lee; N. G. Gurudatt; Woong Heo; Kyung A. Hyun; Hyo Il Jung

doi:10.1016/j.snb.2022.131381

Ultrasensitive detection and risk assessment of di(2-ethylhexyl) phthalate migrated from daily-use plastic products using a nanostructured electrochemical aptasensor

Kyungyeon Lee, N. G. Gurudatt, Woong Heo, Kyung A. Hyun, Hyo Il Jung

Department of Mechanical Engineering

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Di(2-ethylhexyl) phthalate (DEHP) is an endocrine-disrupting chemical that induces numerous health problems when present in the human body in trace amounts. Therefore, for the simple and highly sensitive monitoring of migrated DEHP from daily-use plastic products into water sources, a gold-nanoflowers (AuFs)-structured electrochemical aptasensor was designed in this study. The morphologies of the well-defined AuFs-modified electrodes were investigated and the refined surface indicated enhanced electrochemical properties. DEHP was captured using methylene-blue (MB)-conjugated aptamer immobilized onto the AuFs-structured surface. The devised sensing platform exhibited a low detection limit (2.3 × 10⁻² pg/mL) and a broad dynamic range (0.5 × 10⁰ to 1 × 10⁶ pg/mL). As a proof of concept, the designed aptasensor was successfully utilized as a monitoring tool to detect DEHP migration from plastic products, analyzing the migrated DEHP levels between 2.76 × 10² and 7.75 × 10³ pg/mL. Furthermore, human exposure risk assessment via drinking water for ten items revealed that the carcinogenic risk values of four products exceeded the acceptable level, indicating the vulnerability of human health to even trace amounts of short-term-migrating DEHP. Consequently, our aptasensor shows tremendous potential for monitoring DEHP migrated from real samples with the reliable performance and the high sensitivity.

Original language	English
Article number	131381
Journal	Sensors and Actuators B: Chemical
Volume	357
DOIs	https://doi.org/10.1016/j.snb.2022.131381
Publication status	Published - 2022 Apr 15

Bibliographical note

Funding Information:
This study was supported by the Korea Environment Industry & Technology Institute (KEITI) through the Aquatic Ecosystem Conversion Research Program, funded by the Korea Ministry of Environment (MOE) ( 2020003030007 ), Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry (IPET), funded by Ministry of Agriculture, Food and Rural Affairs(MAFRA) ( 320035031HD030 ), a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. 2020R1A5A1018052 , No. 2021R1A2C301125411 ).

Publisher Copyright:
© 2022 Elsevier B.V.

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.snb.2022.131381

Cite this

@article{288743bdfacc4dca970577d103be4e4a,

title = "Ultrasensitive detection and risk assessment of di(2-ethylhexyl) phthalate migrated from daily-use plastic products using a nanostructured electrochemical aptasensor",

abstract = "Di(2-ethylhexyl) phthalate (DEHP) is an endocrine-disrupting chemical that induces numerous health problems when present in the human body in trace amounts. Therefore, for the simple and highly sensitive monitoring of migrated DEHP from daily-use plastic products into water sources, a gold-nanoflowers (AuFs)-structured electrochemical aptasensor was designed in this study. The morphologies of the well-defined AuFs-modified electrodes were investigated and the refined surface indicated enhanced electrochemical properties. DEHP was captured using methylene-blue (MB)-conjugated aptamer immobilized onto the AuFs-structured surface. The devised sensing platform exhibited a low detection limit (2.3 × 10−2 pg/mL) and a broad dynamic range (0.5 × 100 to 1 × 106 pg/mL). As a proof of concept, the designed aptasensor was successfully utilized as a monitoring tool to detect DEHP migration from plastic products, analyzing the migrated DEHP levels between 2.76 × 102 and 7.75 × 103 pg/mL. Furthermore, human exposure risk assessment via drinking water for ten items revealed that the carcinogenic risk values of four products exceeded the acceptable level, indicating the vulnerability of human health to even trace amounts of short-term-migrating DEHP. Consequently, our aptasensor shows tremendous potential for monitoring DEHP migrated from real samples with the reliable performance and the high sensitivity.",

author = "Kyungyeon Lee and Gurudatt, {N. G.} and Woong Heo and Hyun, {Kyung A.} and Jung, {Hyo Il}",

note = "Funding Information: This study was supported by the Korea Environment Industry & Technology Institute (KEITI) through the Aquatic Ecosystem Conversion Research Program, funded by the Korea Ministry of Environment (MOE) ( 2020003030007 ), Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry (IPET), funded by Ministry of Agriculture, Food and Rural Affairs(MAFRA) ( 320035031HD030 ), a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. 2020R1A5A1018052 , No. 2021R1A2C301125411 ). Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",

year = "2022",

month = apr,

day = "15",

doi = "10.1016/j.snb.2022.131381",

language = "English",

volume = "357",

journal = "Sensors and Actuators B: Chemical",

issn = "0925-4005",

publisher = "Elsevier",

}

TY - JOUR

T1 - Ultrasensitive detection and risk assessment of di(2-ethylhexyl) phthalate migrated from daily-use plastic products using a nanostructured electrochemical aptasensor

AU - Lee, Kyungyeon

AU - Gurudatt, N. G.

AU - Heo, Woong

AU - Hyun, Kyung A.

AU - Jung, Hyo Il

N1 - Funding Information: This study was supported by the Korea Environment Industry & Technology Institute (KEITI) through the Aquatic Ecosystem Conversion Research Program, funded by the Korea Ministry of Environment (MOE) ( 2020003030007 ), Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry (IPET), funded by Ministry of Agriculture, Food and Rural Affairs(MAFRA) ( 320035031HD030 ), a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. 2020R1A5A1018052 , No. 2021R1A2C301125411 ). Publisher Copyright: © 2022 Elsevier B.V.

PY - 2022/4/15

Y1 - 2022/4/15

N2 - Di(2-ethylhexyl) phthalate (DEHP) is an endocrine-disrupting chemical that induces numerous health problems when present in the human body in trace amounts. Therefore, for the simple and highly sensitive monitoring of migrated DEHP from daily-use plastic products into water sources, a gold-nanoflowers (AuFs)-structured electrochemical aptasensor was designed in this study. The morphologies of the well-defined AuFs-modified electrodes were investigated and the refined surface indicated enhanced electrochemical properties. DEHP was captured using methylene-blue (MB)-conjugated aptamer immobilized onto the AuFs-structured surface. The devised sensing platform exhibited a low detection limit (2.3 × 10−2 pg/mL) and a broad dynamic range (0.5 × 100 to 1 × 106 pg/mL). As a proof of concept, the designed aptasensor was successfully utilized as a monitoring tool to detect DEHP migration from plastic products, analyzing the migrated DEHP levels between 2.76 × 102 and 7.75 × 103 pg/mL. Furthermore, human exposure risk assessment via drinking water for ten items revealed that the carcinogenic risk values of four products exceeded the acceptable level, indicating the vulnerability of human health to even trace amounts of short-term-migrating DEHP. Consequently, our aptasensor shows tremendous potential for monitoring DEHP migrated from real samples with the reliable performance and the high sensitivity.

AB - Di(2-ethylhexyl) phthalate (DEHP) is an endocrine-disrupting chemical that induces numerous health problems when present in the human body in trace amounts. Therefore, for the simple and highly sensitive monitoring of migrated DEHP from daily-use plastic products into water sources, a gold-nanoflowers (AuFs)-structured electrochemical aptasensor was designed in this study. The morphologies of the well-defined AuFs-modified electrodes were investigated and the refined surface indicated enhanced electrochemical properties. DEHP was captured using methylene-blue (MB)-conjugated aptamer immobilized onto the AuFs-structured surface. The devised sensing platform exhibited a low detection limit (2.3 × 10−2 pg/mL) and a broad dynamic range (0.5 × 100 to 1 × 106 pg/mL). As a proof of concept, the designed aptasensor was successfully utilized as a monitoring tool to detect DEHP migration from plastic products, analyzing the migrated DEHP levels between 2.76 × 102 and 7.75 × 103 pg/mL. Furthermore, human exposure risk assessment via drinking water for ten items revealed that the carcinogenic risk values of four products exceeded the acceptable level, indicating the vulnerability of human health to even trace amounts of short-term-migrating DEHP. Consequently, our aptasensor shows tremendous potential for monitoring DEHP migrated from real samples with the reliable performance and the high sensitivity.

UR - http://www.scopus.com/inward/record.url?scp=85122780225&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85122780225&partnerID=8YFLogxK

U2 - 10.1016/j.snb.2022.131381

DO - 10.1016/j.snb.2022.131381

M3 - Article

AN - SCOPUS:85122780225

SN - 0925-4005

VL - 357

JO - Sensors and Actuators B: Chemical

JF - Sensors and Actuators B: Chemical

M1 - 131381

ER -

Ultrasensitive detection and risk assessment of di(2-ethylhexyl) phthalate migrated from daily-use plastic products using a nanostructured electrochemical aptasensor

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this