Di(2-ethylhexyl) phthalate (DEHP) is an endocrine-disrupting chemical that induces numerous health problems when present in the human body in trace amounts. Therefore, for the simple and highly sensitive monitoring of migrated DEHP from daily-use plastic products into water sources, a gold-nanoflowers (AuFs)-structured electrochemical aptasensor was designed in this study. The morphologies of the well-defined AuFs-modified electrodes were investigated and the refined surface indicated enhanced electrochemical properties. DEHP was captured using methylene-blue (MB)-conjugated aptamer immobilized onto the AuFs-structured surface. The devised sensing platform exhibited a low detection limit (2.3 × 10−2 pg/mL) and a broad dynamic range (0.5 × 100 to 1 × 106 pg/mL). As a proof of concept, the designed aptasensor was successfully utilized as a monitoring tool to detect DEHP migration from plastic products, analyzing the migrated DEHP levels between 2.76 × 102 and 7.75 × 103 pg/mL. Furthermore, human exposure risk assessment via drinking water for ten items revealed that the carcinogenic risk values of four products exceeded the acceptable level, indicating the vulnerability of human health to even trace amounts of short-term-migrating DEHP. Consequently, our aptasensor shows tremendous potential for monitoring DEHP migrated from real samples with the reliable performance and the high sensitivity.
|Journal||Sensors and Actuators B: Chemical|
|Publication status||Published - 2022 Apr 15|
Bibliographical noteFunding Information:
This study was supported by the Korea Environment Industry & Technology Institute (KEITI) through the Aquatic Ecosystem Conversion Research Program, funded by the Korea Ministry of Environment (MOE) ( 2020003030007 ), Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry (IPET), funded by Ministry of Agriculture, Food and Rural Affairs(MAFRA) ( 320035031HD030 ), a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. 2020R1A5A1018052 , No. 2021R1A2C301125411 ).
© 2022 Elsevier B.V.
All Science Journal Classification (ASJC) codes
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics
- Surfaces, Coatings and Films
- Metals and Alloys
- Electrical and Electronic Engineering
- Materials Chemistry