To prevent surgical site infection (SSI), which significantly increases the rate morbidity and mortality, eliminating microorganisms is prominent. Antimicrobial resistance is identified as a global health challenge. This work proposes a new strategy to eliminate microorganisms of deep tissue through electrical stimulation with an ultrasound (US)-driven implantable, biodegradable, and vibrant triboelectric nanogenerator (IBV-TENG). After a programmed lifetime, the IBV-TENG can be eliminated by provoking the on-demand device dissolution by controlling US intensity with no surgical removal of the device from the body. A voltage of ≈4 V and current of ≈22 µA generated from IBV-TENG under ultrasound in vitro, confirming inactivating ≈100% of Staphylococcus aureus and ≈99% of Escherichia coli. Furthermore, ex vivo results show that IBV-TENG implanted under porcine tissue successfully inactivates bacteria. This antibacterial technology is expected to be a countermeasure strategy against SSIs, increasing life expectancy and healthcare quality by preventing microorganisms of deep tissue.
|Publication status||Published - 2023 Jan 25|
Bibliographical noteFunding Information:
I.M.I. and B.K. contributed equally to this work. This work was financially supported by Basic Science Research Programs (2022R1A3B1078291 and 2021R1A2C2010990), the Nano Material Technology Development Program (2020M3H4A1A03084600), and the Bio & Medical Technology Development Program (2022M3E5E9082206) through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (MSIT).
© 2022 The Authors. Advanced Science published by Wiley-VCH GmbH.
All Science Journal Classification (ASJC) codes
- Medicine (miscellaneous)
- Chemical Engineering(all)
- Materials Science(all)
- Biochemistry, Genetics and Molecular Biology (miscellaneous)
- Physics and Astronomy(all)