Ultrasound-Driven On-Demand Transient Triboelectric Nanogenerator for Subcutaneous Antibacterial Activity

Iman M. Imani; Bosung Kim; Xiao Xiao; Najaf Rubab; Byung Joon Park; Young Jun Kim; Pin Zhao; Minki Kang; Sang Woo Kim

doi:10.1002/advs.202204801

Ultrasound-Driven On-Demand Transient Triboelectric Nanogenerator for Subcutaneous Antibacterial Activity

Iman M. Imani, Bosung Kim, Xiao Xiao, Najaf Rubab, Byung Joon Park, Young Jun Kim, Pin Zhao, Minki Kang, Sang Woo Kim

Department of Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

To prevent surgical site infection (SSI), which significantly increases the rate morbidity and mortality, eliminating microorganisms is prominent. Antimicrobial resistance is identified as a global health challenge. This work proposes a new strategy to eliminate microorganisms of deep tissue through electrical stimulation with an ultrasound (US)-driven implantable, biodegradable, and vibrant triboelectric nanogenerator (IBV-TENG). After a programmed lifetime, the IBV-TENG can be eliminated by provoking the on-demand device dissolution by controlling US intensity with no surgical removal of the device from the body. A voltage of ≈4 V and current of ≈22 µA generated from IBV-TENG under ultrasound in vitro, confirming inactivating ≈100% of Staphylococcus aureus and ≈99% of Escherichia coli. Furthermore, ex vivo results show that IBV-TENG implanted under porcine tissue successfully inactivates bacteria. This antibacterial technology is expected to be a countermeasure strategy against SSIs, increasing life expectancy and healthcare quality by preventing microorganisms of deep tissue.

Original language	English
Article number	2204801
Journal	Advanced Science
Volume	10
Issue number	3
DOIs	https://doi.org/10.1002/advs.202204801
Publication status	Published - 2023 Jan 25

Bibliographical note

Funding Information:
I.M.I. and B.K. contributed equally to this work. This work was financially supported by Basic Science Research Programs (2022R1A3B1078291 and 2021R1A2C2010990), the Nano Material Technology Development Program (2020M3H4A1A03084600), and the Bio & Medical Technology Development Program (2022M3E5E9082206) through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (MSIT).

Publisher Copyright:
© 2022 The Authors. Advanced Science published by Wiley-VCH GmbH.

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
Chemical Engineering(all)
Materials Science(all)
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Engineering(all)
Physics and Astronomy(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/advs.202204801

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title = "Ultrasound-Driven On-Demand Transient Triboelectric Nanogenerator for Subcutaneous Antibacterial Activity",

abstract = "To prevent surgical site infection (SSI), which significantly increases the rate morbidity and mortality, eliminating microorganisms is prominent. Antimicrobial resistance is identified as a global health challenge. This work proposes a new strategy to eliminate microorganisms of deep tissue through electrical stimulation with an ultrasound (US)-driven implantable, biodegradable, and vibrant triboelectric nanogenerator (IBV-TENG). After a programmed lifetime, the IBV-TENG can be eliminated by provoking the on-demand device dissolution by controlling US intensity with no surgical removal of the device from the body. A voltage of ≈4 V and current of ≈22 µA generated from IBV-TENG under ultrasound in vitro, confirming inactivating ≈100% of Staphylococcus aureus and ≈99% of Escherichia coli. Furthermore, ex vivo results show that IBV-TENG implanted under porcine tissue successfully inactivates bacteria. This antibacterial technology is expected to be a countermeasure strategy against SSIs, increasing life expectancy and healthcare quality by preventing microorganisms of deep tissue.",

author = "Imani, {Iman M.} and Bosung Kim and Xiao Xiao and Najaf Rubab and Park, {Byung Joon} and Kim, {Young Jun} and Pin Zhao and Minki Kang and Kim, {Sang Woo}",

note = "Funding Information: I.M.I. and B.K. contributed equally to this work. This work was financially supported by Basic Science Research Programs (2022R1A3B1078291 and 2021R1A2C2010990), the Nano Material Technology Development Program (2020M3H4A1A03084600), and the Bio & Medical Technology Development Program (2022M3E5E9082206) through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (MSIT). Publisher Copyright: {\textcopyright} 2022 The Authors. Advanced Science published by Wiley-VCH GmbH.",

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AU - Park, Byung Joon

AU - Kim, Young Jun

AU - Zhao, Pin

AU - Kang, Minki

AU - Kim, Sang Woo

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N2 - To prevent surgical site infection (SSI), which significantly increases the rate morbidity and mortality, eliminating microorganisms is prominent. Antimicrobial resistance is identified as a global health challenge. This work proposes a new strategy to eliminate microorganisms of deep tissue through electrical stimulation with an ultrasound (US)-driven implantable, biodegradable, and vibrant triboelectric nanogenerator (IBV-TENG). After a programmed lifetime, the IBV-TENG can be eliminated by provoking the on-demand device dissolution by controlling US intensity with no surgical removal of the device from the body. A voltage of ≈4 V and current of ≈22 µA generated from IBV-TENG under ultrasound in vitro, confirming inactivating ≈100% of Staphylococcus aureus and ≈99% of Escherichia coli. Furthermore, ex vivo results show that IBV-TENG implanted under porcine tissue successfully inactivates bacteria. This antibacterial technology is expected to be a countermeasure strategy against SSIs, increasing life expectancy and healthcare quality by preventing microorganisms of deep tissue.

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Ultrasound-Driven On-Demand Transient Triboelectric Nanogenerator for Subcutaneous Antibacterial Activity

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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