Ultrasound-guided fine-needle aspiration biopsy in nonpalpable thyroid nodules: Is it useful in infracentimetric nodules?

Seong Jun Kim, Eun Kyung Kim, Cheong Soo Park, Woong Youn Chung, Ki Keun Oh, Hyung Sik Yoo

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The purpose of this study was to evaluate the usefulness of an ultrasound-guided fine-needle aspiration biopsy (US-FNAB) for the evaluation and treatment planning of nonpalpable thyroid lesions, including infracentimetric nodules. One hundred and twenty one patients underwent US-FNAB for 149 non-palpable solid nodules. Sixty-five patients underwent surgery, and 84 were followed up for at least 36 months. The results of the US-FNAB correlated with the pathological findings and clinical follow-up results. The nodules ranged from 0.3 to 2 cm in diameter, with a mean of 0.8cm. Among the 149 nodules, 115 were infracentimetric and 34 were centimetric or supracentimetric in size. Of the 149 thyroid nodules, US-FNAB was true positive in 43, true negative in 90, false positive in 7 and false negative in 1. In 8 cases, the lesion was inadequately sampled. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of the US-FNAB for the infracentimetric nodules were 96.9, 93.4, 86.1, 98.6 and 94.4%, and for the centimetric or supracentimetric nodules, were 100, 90.5, 85.7, 100 and 93.9%, respectively. There were no significant differences in the results between the infracentimetric and centimetric or supracentimetric nodules. In conclusion, an US-FNAB is a useful tool for determining the treatment plan of non-palpable solid thyroid nodules, even when less than cm in diameter, and shows high sensitivity, specificity and accuracy.

Original languageEnglish
Pages (from-to)635-640
Number of pages6
JournalYonsei medical journal
Volume44
Issue number4
DOIs
Publication statusPublished - 2003 Aug 30

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Thyroid Nodule
Fine Needle Biopsy
Sensitivity and Specificity
Thyroid Gland
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kim, Seong Jun ; Kim, Eun Kyung ; Park, Cheong Soo ; Chung, Woong Youn ; Oh, Ki Keun ; Yoo, Hyung Sik. / Ultrasound-guided fine-needle aspiration biopsy in nonpalpable thyroid nodules : Is it useful in infracentimetric nodules?. In: Yonsei medical journal. 2003 ; Vol. 44, No. 4. pp. 635-640.
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Ultrasound-guided fine-needle aspiration biopsy in nonpalpable thyroid nodules : Is it useful in infracentimetric nodules? / Kim, Seong Jun; Kim, Eun Kyung; Park, Cheong Soo; Chung, Woong Youn; Oh, Ki Keun; Yoo, Hyung Sik.

In: Yonsei medical journal, Vol. 44, No. 4, 30.08.2003, p. 635-640.

Research output: Contribution to journalArticle

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N2 - The purpose of this study was to evaluate the usefulness of an ultrasound-guided fine-needle aspiration biopsy (US-FNAB) for the evaluation and treatment planning of nonpalpable thyroid lesions, including infracentimetric nodules. One hundred and twenty one patients underwent US-FNAB for 149 non-palpable solid nodules. Sixty-five patients underwent surgery, and 84 were followed up for at least 36 months. The results of the US-FNAB correlated with the pathological findings and clinical follow-up results. The nodules ranged from 0.3 to 2 cm in diameter, with a mean of 0.8cm. Among the 149 nodules, 115 were infracentimetric and 34 were centimetric or supracentimetric in size. Of the 149 thyroid nodules, US-FNAB was true positive in 43, true negative in 90, false positive in 7 and false negative in 1. In 8 cases, the lesion was inadequately sampled. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of the US-FNAB for the infracentimetric nodules were 96.9, 93.4, 86.1, 98.6 and 94.4%, and for the centimetric or supracentimetric nodules, were 100, 90.5, 85.7, 100 and 93.9%, respectively. There were no significant differences in the results between the infracentimetric and centimetric or supracentimetric nodules. In conclusion, an US-FNAB is a useful tool for determining the treatment plan of non-palpable solid thyroid nodules, even when less than cm in diameter, and shows high sensitivity, specificity and accuracy.

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