Ultraviolet B activated 1,25(OH)2D affects the level of fibroblast growth factor-23 in human

JuHee Lee, Kyoung Min Kim, Dong Yeob Shin, Han Seok Choi, Do Young Kim, Yoon Kee Park, Sungkil Lim, Yumie Rhee

Research output: Contribution to journalArticle

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Abstract

Fibroblast growth factor 23 (FGF-23) is known as a phosphaturic factor regulating phosphate homeostasis. Several studies suggest that dietary phosphate, serum phosphate and 1,25-dihydroxyvitamin D [1,25(OH)2D] are candidate regulators of FGF-23. While the human studies, which modulated the dietary or serum phosphate showed in rather controversial results, manipulation of the active vitamin D definitely affected FGF-23 in animals. This study was conducted to elucidate the relationship between active vitamin D directly stimulated by ultraviolet B (UVB) exposure and FGF-23 level in human. Ten healthy young adults were recruited to get the UVB exposure thrice a week at sub-minimal erythemal dose with gradual increment by 10% only for 4 weeks. Serum calcium, phosphate, mineral-related hormones and bone turnover markers were analyzed before and after the UVB exposure every 4 week for 12 whole weeks. Twenty fivehydroxyvitamin D [25(OH)D] increased by 115% (19.8 ng/mL to 40.5 ng/mL, p < 0.001) after 4 weeks of UVB exposure. While 1,25(OH)2D increased by 75% (49.9 pg/mL to 64.4 pg/mL, p < 0.001) then both level decreased after 4 weeks of withdrawal. C-telopeptide peaked at 2nd week then decreased, while osteocalcin increased gradually. FGF-23 started to increase from the 4th week of UVB exposure then significantly at the 4th week after withdrawal of UVB (27.8 pg/mL to 41.4 pg/mL, p < 0.05). UVB exposure effectively increased 1,25(OH) 2D with delayed stimulatory effect on FGF-23. This result could support the regulatory loop of 1,25(OH)2D and FGF-23 in human, FGF-23 regulation by 1,25(OH)2D.

Original languageEnglish
Pages (from-to)81-86
Number of pages6
JournalEndocrine Journal
Volume60
Issue number1
DOIs
Publication statusPublished - 2013 Feb 13

Fingerprint

Phosphates
Vitamin D
Serum
fibroblast growth factor 23
Bone Remodeling
Osteocalcin
Minerals
Young Adult
Homeostasis
Hormones

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Lee, JuHee ; Kim, Kyoung Min ; Shin, Dong Yeob ; Choi, Han Seok ; Kim, Do Young ; Park, Yoon Kee ; Lim, Sungkil ; Rhee, Yumie. / Ultraviolet B activated 1,25(OH)2D affects the level of fibroblast growth factor-23 in human. In: Endocrine Journal. 2013 ; Vol. 60, No. 1. pp. 81-86.
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abstract = "Fibroblast growth factor 23 (FGF-23) is known as a phosphaturic factor regulating phosphate homeostasis. Several studies suggest that dietary phosphate, serum phosphate and 1,25-dihydroxyvitamin D [1,25(OH)2D] are candidate regulators of FGF-23. While the human studies, which modulated the dietary or serum phosphate showed in rather controversial results, manipulation of the active vitamin D definitely affected FGF-23 in animals. This study was conducted to elucidate the relationship between active vitamin D directly stimulated by ultraviolet B (UVB) exposure and FGF-23 level in human. Ten healthy young adults were recruited to get the UVB exposure thrice a week at sub-minimal erythemal dose with gradual increment by 10{\%} only for 4 weeks. Serum calcium, phosphate, mineral-related hormones and bone turnover markers were analyzed before and after the UVB exposure every 4 week for 12 whole weeks. Twenty fivehydroxyvitamin D [25(OH)D] increased by 115{\%} (19.8 ng/mL to 40.5 ng/mL, p < 0.001) after 4 weeks of UVB exposure. While 1,25(OH)2D increased by 75{\%} (49.9 pg/mL to 64.4 pg/mL, p < 0.001) then both level decreased after 4 weeks of withdrawal. C-telopeptide peaked at 2nd week then decreased, while osteocalcin increased gradually. FGF-23 started to increase from the 4th week of UVB exposure then significantly at the 4th week after withdrawal of UVB (27.8 pg/mL to 41.4 pg/mL, p < 0.05). UVB exposure effectively increased 1,25(OH) 2D with delayed stimulatory effect on FGF-23. This result could support the regulatory loop of 1,25(OH)2D and FGF-23 in human, FGF-23 regulation by 1,25(OH)2D.",
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Ultraviolet B activated 1,25(OH)2D affects the level of fibroblast growth factor-23 in human. / Lee, JuHee; Kim, Kyoung Min; Shin, Dong Yeob; Choi, Han Seok; Kim, Do Young; Park, Yoon Kee; Lim, Sungkil; Rhee, Yumie.

In: Endocrine Journal, Vol. 60, No. 1, 13.02.2013, p. 81-86.

Research output: Contribution to journalArticle

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