The ability of cancer-targeted nanoparticles (NPs) to reach their site of action and evoke a desired biological response after intravenous injection is critical to achieve clinically significant in vivo efficacy. Throughout their journey in the body, NPs must successfully traverse biological environments such as blood circulation and tumor microenvironments. The interactions that occur at the interface between NPs and biological components are complex, requiring a thorough understanding of the nano-bio interactions to design NPs with maximal therapeutic indices. In this article, we review the challenges presented by the multiscale, important biocompartments that NPs face, describe the crucial nano-bio interactions present at each stage, and discuss potential strategies to overcome those challenges. This review suggests design considerations for NPs to optimally modulate their physicochemical properties to achieve desired biological responses, which are expected to aid chemists, engineers, and clinical scientists to design and develop highly effective delivery platforms for cancer therapy.
Bibliographical noteFunding Information:
This work was supported by the Susan G. Komen Foundation under Grant No. KG100713, Alex's Lemonade Stand Foundation for Childhood Cancer, and Korean Ministry of Small & Medium Business Administration. R.M.P. acknowledges support from UIC in the form of the Dean's Scholarship.
© 2014 Materials Research Society.
All Science Journal Classification (ASJC) codes
- Materials Science(all)
- Condensed Matter Physics
- Physical and Theoretical Chemistry