Undifferentiated histology after endoscopic resection may predict synchronous and metachronous occurrence of early gastric cancer

Ju Hee Seo, Jun Chul Park, Yu Jin Kim, Sung Kwan Shin, Yong Chan Lee, Sang Kil Lee

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: Endoscopic resection (endoscopic mucosal resection, EMR, and endoscopic submucosal dissection, ESD) has been accepted worldwide as a less invasive standard treatment for early gastric cancer (EGC). However, the risk of synchronous and metachronous gastric cancer developing in the post-endoscopic resection patient has become a major problem. We investigated the incidence and characteristics of synchronous and metachronous multiple gastric cancers in a retrospective study of patients with EGC after endoscopic resection. Patients and Methods: We studied the clinicopathological features of 235 patients with EGC who had undergone endoscopic resection and were periodically followed up using endoscopic examinations (181 with a single lesion, 34 synchronous multiple lesions, and 20 metachronous multiple lesions). Results: The overall incidence of synchronous and metachronous multiple gastric cancer was 14.5 and 8.5%, respectively, during a follow-up of 12-77 (median 26.5) months. Undifferentiated histology of the primary lesion was related to the occurrence of synchronous gastric cancer (p < 0.001). Undifferentiated histology and upper location of the primary lesion were correlated with the occurrence of metachronous gastric cancer (p = 0.002, 0.001). Most synchronous and metachronous lesions were well to moderately differentiated (82.4 and 80.0%); however, the proportion with undifferentiated histology (including poorly differentiated carcinoma and signet ring cell carcinoma) in synchronous and metachronous gastric cancer was significantly higher than in single gastric cancer (p = 0.008). Conclusions: Undifferentiated histology of EGC may predict the occurrence of synchronous and metachronous lesions after endoscopic resection.

Original languageEnglish
Pages (from-to)35-42
Number of pages8
JournalDigestion
Volume81
Issue number1
DOIs
Publication statusPublished - 2010 Feb 1

Fingerprint

Stomach Neoplasms
Histology
Signet Ring Cell Carcinoma
Incidence
Retrospective Studies
Carcinoma

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

@article{e45f81e10bad426dac3a8bfe4f80037f,
title = "Undifferentiated histology after endoscopic resection may predict synchronous and metachronous occurrence of early gastric cancer",
abstract = "Background: Endoscopic resection (endoscopic mucosal resection, EMR, and endoscopic submucosal dissection, ESD) has been accepted worldwide as a less invasive standard treatment for early gastric cancer (EGC). However, the risk of synchronous and metachronous gastric cancer developing in the post-endoscopic resection patient has become a major problem. We investigated the incidence and characteristics of synchronous and metachronous multiple gastric cancers in a retrospective study of patients with EGC after endoscopic resection. Patients and Methods: We studied the clinicopathological features of 235 patients with EGC who had undergone endoscopic resection and were periodically followed up using endoscopic examinations (181 with a single lesion, 34 synchronous multiple lesions, and 20 metachronous multiple lesions). Results: The overall incidence of synchronous and metachronous multiple gastric cancer was 14.5 and 8.5{\%}, respectively, during a follow-up of 12-77 (median 26.5) months. Undifferentiated histology of the primary lesion was related to the occurrence of synchronous gastric cancer (p < 0.001). Undifferentiated histology and upper location of the primary lesion were correlated with the occurrence of metachronous gastric cancer (p = 0.002, 0.001). Most synchronous and metachronous lesions were well to moderately differentiated (82.4 and 80.0{\%}); however, the proportion with undifferentiated histology (including poorly differentiated carcinoma and signet ring cell carcinoma) in synchronous and metachronous gastric cancer was significantly higher than in single gastric cancer (p = 0.008). Conclusions: Undifferentiated histology of EGC may predict the occurrence of synchronous and metachronous lesions after endoscopic resection.",
author = "Seo, {Ju Hee} and Park, {Jun Chul} and Kim, {Yu Jin} and Shin, {Sung Kwan} and Lee, {Yong Chan} and Lee, {Sang Kil}",
year = "2010",
month = "2",
day = "1",
doi = "10.1159/000235921",
language = "English",
volume = "81",
pages = "35--42",
journal = "Digestion",
issn = "0012-2823",
publisher = "S. Karger AG",
number = "1",

}

Undifferentiated histology after endoscopic resection may predict synchronous and metachronous occurrence of early gastric cancer. / Seo, Ju Hee; Park, Jun Chul; Kim, Yu Jin; Shin, Sung Kwan; Lee, Yong Chan; Lee, Sang Kil.

In: Digestion, Vol. 81, No. 1, 01.02.2010, p. 35-42.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Undifferentiated histology after endoscopic resection may predict synchronous and metachronous occurrence of early gastric cancer

AU - Seo, Ju Hee

AU - Park, Jun Chul

AU - Kim, Yu Jin

AU - Shin, Sung Kwan

AU - Lee, Yong Chan

AU - Lee, Sang Kil

PY - 2010/2/1

Y1 - 2010/2/1

N2 - Background: Endoscopic resection (endoscopic mucosal resection, EMR, and endoscopic submucosal dissection, ESD) has been accepted worldwide as a less invasive standard treatment for early gastric cancer (EGC). However, the risk of synchronous and metachronous gastric cancer developing in the post-endoscopic resection patient has become a major problem. We investigated the incidence and characteristics of synchronous and metachronous multiple gastric cancers in a retrospective study of patients with EGC after endoscopic resection. Patients and Methods: We studied the clinicopathological features of 235 patients with EGC who had undergone endoscopic resection and were periodically followed up using endoscopic examinations (181 with a single lesion, 34 synchronous multiple lesions, and 20 metachronous multiple lesions). Results: The overall incidence of synchronous and metachronous multiple gastric cancer was 14.5 and 8.5%, respectively, during a follow-up of 12-77 (median 26.5) months. Undifferentiated histology of the primary lesion was related to the occurrence of synchronous gastric cancer (p < 0.001). Undifferentiated histology and upper location of the primary lesion were correlated with the occurrence of metachronous gastric cancer (p = 0.002, 0.001). Most synchronous and metachronous lesions were well to moderately differentiated (82.4 and 80.0%); however, the proportion with undifferentiated histology (including poorly differentiated carcinoma and signet ring cell carcinoma) in synchronous and metachronous gastric cancer was significantly higher than in single gastric cancer (p = 0.008). Conclusions: Undifferentiated histology of EGC may predict the occurrence of synchronous and metachronous lesions after endoscopic resection.

AB - Background: Endoscopic resection (endoscopic mucosal resection, EMR, and endoscopic submucosal dissection, ESD) has been accepted worldwide as a less invasive standard treatment for early gastric cancer (EGC). However, the risk of synchronous and metachronous gastric cancer developing in the post-endoscopic resection patient has become a major problem. We investigated the incidence and characteristics of synchronous and metachronous multiple gastric cancers in a retrospective study of patients with EGC after endoscopic resection. Patients and Methods: We studied the clinicopathological features of 235 patients with EGC who had undergone endoscopic resection and were periodically followed up using endoscopic examinations (181 with a single lesion, 34 synchronous multiple lesions, and 20 metachronous multiple lesions). Results: The overall incidence of synchronous and metachronous multiple gastric cancer was 14.5 and 8.5%, respectively, during a follow-up of 12-77 (median 26.5) months. Undifferentiated histology of the primary lesion was related to the occurrence of synchronous gastric cancer (p < 0.001). Undifferentiated histology and upper location of the primary lesion were correlated with the occurrence of metachronous gastric cancer (p = 0.002, 0.001). Most synchronous and metachronous lesions were well to moderately differentiated (82.4 and 80.0%); however, the proportion with undifferentiated histology (including poorly differentiated carcinoma and signet ring cell carcinoma) in synchronous and metachronous gastric cancer was significantly higher than in single gastric cancer (p = 0.008). Conclusions: Undifferentiated histology of EGC may predict the occurrence of synchronous and metachronous lesions after endoscopic resection.

UR - http://www.scopus.com/inward/record.url?scp=72149128486&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=72149128486&partnerID=8YFLogxK

U2 - 10.1159/000235921

DO - 10.1159/000235921

M3 - Article

C2 - 20029207

AN - SCOPUS:72149128486

VL - 81

SP - 35

EP - 42

JO - Digestion

JF - Digestion

SN - 0012-2823

IS - 1

ER -