Unique characteristics and failure patterns of metaplastic breast cancer in contrast to invasive ductal carcinoma: A retrospective multicenter case-control study (KROG 13-07)

Jeong Il Yu, Doo Ho Choi, Seung Jae Huh, Sung Ja Ahn, Ji Shin Lee, Kyung Hwan Shin, Youngmee Kwon, Yong Bae Kim, Chang Ok Suh, Jin Hee Kim, Jihyoung Cho, In Ah Kim, Jong Hoon Lee, Won Park

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background This retrospective study was performed to investigate the need for management modification in MBC according to evaluation of characteristics and failure patterns compared with IDC. Patients and Methods We performed this multicenter study taking MBC and randomly assigned IDC cases matched for age (± 3 years), pathologic stage (T and N), locoregional treatment methods (surgery with or without radiation therapy), and period of treatment (± 6 months) that occurred from January 1999 to November 2011 in the 6 institutions of the Korean Radiation Oncology Group. Results A total of 144 female MBC patients were enrolled. The median follow-up was 51 months (range, 1-186 months). The rates of positivity for estrogen receptor (P <.001), progesterone receptor (P <.001), and HER2 (P =.007) were significantly lower in MBC patients. During follow-up, recurrence developed in 22 (15.3%) MBC and 6 (4.2%) IDC patients (P =.002). The median time to recurrence of MBC and IDC was 15 months and 24 months, respectively. Most instances of recurrence in MBC developed in the triple-negative (TN) subgroup (TN-MBC). In particular, locoregional recurrence developed exclusively in the TN-MBC subgroup. In the TN-MBC subgroup, the number of risk factors (pT2-3, N1-3) was related to significant differences in overall survival (P =.001) and recurrence-free survival (P <.001). Conclusion The MBC patients had a higher rate of TN, poorer differentiation, and a higher recurrence rate than did the IDC patients. Considering the unique characteristics and failure patterns, it is necessary to modify the current management guidelines for MBC.

Original languageEnglish
Pages (from-to)e105-e115
JournalClinical Breast Cancer
Volume15
Issue number2
DOIs
Publication statusPublished - 2015 Apr 1

Fingerprint

Ductal Carcinoma
Case-Control Studies
Breast Neoplasms
Recurrence
Radiation Oncology
Survival
Progesterone Receptors
Estrogen Receptors
Multicenter Studies
Radiotherapy
Retrospective Studies
Guidelines
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Yu, Jeong Il ; Choi, Doo Ho ; Huh, Seung Jae ; Ahn, Sung Ja ; Lee, Ji Shin ; Shin, Kyung Hwan ; Kwon, Youngmee ; Kim, Yong Bae ; Suh, Chang Ok ; Kim, Jin Hee ; Cho, Jihyoung ; Kim, In Ah ; Lee, Jong Hoon ; Park, Won. / Unique characteristics and failure patterns of metaplastic breast cancer in contrast to invasive ductal carcinoma : A retrospective multicenter case-control study (KROG 13-07). In: Clinical Breast Cancer. 2015 ; Vol. 15, No. 2. pp. e105-e115.
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title = "Unique characteristics and failure patterns of metaplastic breast cancer in contrast to invasive ductal carcinoma: A retrospective multicenter case-control study (KROG 13-07)",
abstract = "Background This retrospective study was performed to investigate the need for management modification in MBC according to evaluation of characteristics and failure patterns compared with IDC. Patients and Methods We performed this multicenter study taking MBC and randomly assigned IDC cases matched for age (± 3 years), pathologic stage (T and N), locoregional treatment methods (surgery with or without radiation therapy), and period of treatment (± 6 months) that occurred from January 1999 to November 2011 in the 6 institutions of the Korean Radiation Oncology Group. Results A total of 144 female MBC patients were enrolled. The median follow-up was 51 months (range, 1-186 months). The rates of positivity for estrogen receptor (P <.001), progesterone receptor (P <.001), and HER2 (P =.007) were significantly lower in MBC patients. During follow-up, recurrence developed in 22 (15.3{\%}) MBC and 6 (4.2{\%}) IDC patients (P =.002). The median time to recurrence of MBC and IDC was 15 months and 24 months, respectively. Most instances of recurrence in MBC developed in the triple-negative (TN) subgroup (TN-MBC). In particular, locoregional recurrence developed exclusively in the TN-MBC subgroup. In the TN-MBC subgroup, the number of risk factors (pT2-3, N1-3) was related to significant differences in overall survival (P =.001) and recurrence-free survival (P <.001). Conclusion The MBC patients had a higher rate of TN, poorer differentiation, and a higher recurrence rate than did the IDC patients. Considering the unique characteristics and failure patterns, it is necessary to modify the current management guidelines for MBC.",
author = "Yu, {Jeong Il} and Choi, {Doo Ho} and Huh, {Seung Jae} and Ahn, {Sung Ja} and Lee, {Ji Shin} and Shin, {Kyung Hwan} and Youngmee Kwon and Kim, {Yong Bae} and Suh, {Chang Ok} and Kim, {Jin Hee} and Jihyoung Cho and Kim, {In Ah} and Lee, {Jong Hoon} and Won Park",
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Unique characteristics and failure patterns of metaplastic breast cancer in contrast to invasive ductal carcinoma : A retrospective multicenter case-control study (KROG 13-07). / Yu, Jeong Il; Choi, Doo Ho; Huh, Seung Jae; Ahn, Sung Ja; Lee, Ji Shin; Shin, Kyung Hwan; Kwon, Youngmee; Kim, Yong Bae; Suh, Chang Ok; Kim, Jin Hee; Cho, Jihyoung; Kim, In Ah; Lee, Jong Hoon; Park, Won.

In: Clinical Breast Cancer, Vol. 15, No. 2, 01.04.2015, p. e105-e115.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Unique characteristics and failure patterns of metaplastic breast cancer in contrast to invasive ductal carcinoma

T2 - A retrospective multicenter case-control study (KROG 13-07)

AU - Yu, Jeong Il

AU - Choi, Doo Ho

AU - Huh, Seung Jae

AU - Ahn, Sung Ja

AU - Lee, Ji Shin

AU - Shin, Kyung Hwan

AU - Kwon, Youngmee

AU - Kim, Yong Bae

AU - Suh, Chang Ok

AU - Kim, Jin Hee

AU - Cho, Jihyoung

AU - Kim, In Ah

AU - Lee, Jong Hoon

AU - Park, Won

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Background This retrospective study was performed to investigate the need for management modification in MBC according to evaluation of characteristics and failure patterns compared with IDC. Patients and Methods We performed this multicenter study taking MBC and randomly assigned IDC cases matched for age (± 3 years), pathologic stage (T and N), locoregional treatment methods (surgery with or without radiation therapy), and period of treatment (± 6 months) that occurred from January 1999 to November 2011 in the 6 institutions of the Korean Radiation Oncology Group. Results A total of 144 female MBC patients were enrolled. The median follow-up was 51 months (range, 1-186 months). The rates of positivity for estrogen receptor (P <.001), progesterone receptor (P <.001), and HER2 (P =.007) were significantly lower in MBC patients. During follow-up, recurrence developed in 22 (15.3%) MBC and 6 (4.2%) IDC patients (P =.002). The median time to recurrence of MBC and IDC was 15 months and 24 months, respectively. Most instances of recurrence in MBC developed in the triple-negative (TN) subgroup (TN-MBC). In particular, locoregional recurrence developed exclusively in the TN-MBC subgroup. In the TN-MBC subgroup, the number of risk factors (pT2-3, N1-3) was related to significant differences in overall survival (P =.001) and recurrence-free survival (P <.001). Conclusion The MBC patients had a higher rate of TN, poorer differentiation, and a higher recurrence rate than did the IDC patients. Considering the unique characteristics and failure patterns, it is necessary to modify the current management guidelines for MBC.

AB - Background This retrospective study was performed to investigate the need for management modification in MBC according to evaluation of characteristics and failure patterns compared with IDC. Patients and Methods We performed this multicenter study taking MBC and randomly assigned IDC cases matched for age (± 3 years), pathologic stage (T and N), locoregional treatment methods (surgery with or without radiation therapy), and period of treatment (± 6 months) that occurred from January 1999 to November 2011 in the 6 institutions of the Korean Radiation Oncology Group. Results A total of 144 female MBC patients were enrolled. The median follow-up was 51 months (range, 1-186 months). The rates of positivity for estrogen receptor (P <.001), progesterone receptor (P <.001), and HER2 (P =.007) were significantly lower in MBC patients. During follow-up, recurrence developed in 22 (15.3%) MBC and 6 (4.2%) IDC patients (P =.002). The median time to recurrence of MBC and IDC was 15 months and 24 months, respectively. Most instances of recurrence in MBC developed in the triple-negative (TN) subgroup (TN-MBC). In particular, locoregional recurrence developed exclusively in the TN-MBC subgroup. In the TN-MBC subgroup, the number of risk factors (pT2-3, N1-3) was related to significant differences in overall survival (P =.001) and recurrence-free survival (P <.001). Conclusion The MBC patients had a higher rate of TN, poorer differentiation, and a higher recurrence rate than did the IDC patients. Considering the unique characteristics and failure patterns, it is necessary to modify the current management guidelines for MBC.

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U2 - 10.1016/j.clbc.2014.10.002

DO - 10.1016/j.clbc.2014.10.002

M3 - Article

C2 - 25459069

AN - SCOPUS:84924954345

VL - 15

SP - e105-e115

JO - Clinical Breast Cancer

JF - Clinical Breast Cancer

SN - 1526-8209

IS - 2

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