Universal and selective interventions to promote good mental health in young people: Systematic review and meta-analysis

Gonzalo Salazar de Pablo; Andrea De Micheli; Dorien H. Nieman; Christoph U. Correll; Lars Vedel Kessing; Andrea Pfennig; Andreas Bechdolf; Stefan Borgwardt; Celso Arango; Therese van Amelsvoort; Eduard Vieta; Marco Solmi; Dominic Oliver; Ana Catalan; Valeria Verdino; Lucia Di Maggio; Ilaria Bonoldi; Julio Vaquerizo-Serrano; Ottone Baccaredda Boy; Umberto Provenzani; Francesca Ruzzi; Federica Calorio; Guido Nosari; Benedetto Di Marco; Irene Famularo; Silvia Molteni; Eleonora Filosi; Martina Mensi; Umberto Balottin; Pierluigi Politi; Jae Il Shin; Paolo Fusar-Poli

doi:10.1016/j.euroneuro.2020.10.007

Universal and selective interventions to promote good mental health in young people: Systematic review and meta-analysis

Gonzalo Salazar de Pablo, Andrea De Micheli, Dorien H. Nieman, Christoph U. Correll, Lars Vedel Kessing, Andrea Pfennig, Andreas Bechdolf, Stefan Borgwardt, Celso Arango, Therese van Amelsvoort, Eduard Vieta, Marco Solmi, Dominic Oliver, Ana Catalan, Valeria Verdino, Lucia Di Maggio, Ilaria Bonoldi, Julio Vaquerizo-Serrano, Ottone Baccaredda Boy, Umberto ProvenzaniFrancesca Ruzzi, Federica Calorio, Guido Nosari, Benedetto Di Marco, Irene Famularo, Silvia Molteni, Eleonora Filosi, Martina Mensi, Umberto Balottin, Pierluigi Politi, Jae Il Shin, Paolo Fusar-Poli

Department of Pediatrics

Research output: Contribution to journal › Review article › peer-review

41 Citations (Scopus)

Abstract

Promotion of good mental health in young people is important. Our aim was to evaluate the consistency and magnitude of the efficacy of universal/selective interventions to promote good mental health. A systematic PRISMA/RIGHT-compliant meta-analysis (PROSPERO: CRD42018088708) search of Web of Science until 04/31/2019 identified original studies comparing the efficacy of universal/selective interventions for good mental health vs a control group, in samples with a mean age <35 years. Meta-analytical random-effects model, heterogeneity statistics, assessment of publication bias, study quality and sensitivity analyses investigated the efficacy (Hedges’ g=effect size, ES) of universal/selective interventions to promote 14 good mental health outcomes defined a-priori. 276 studies were included (total participants: 159,508, 79,142 interventions and 80,366 controls), mean age=15.0 (SD=7.4); female=56.0%. There was a significant overall improvement in 10/13 good mental health outcome categories that could be meta-analysed: compared to controls, interventions significantly improved (in descending order of magnitude) mental health literacy (ES=0.685, p<0.001), emotions (ES=0.541, p<0.001), self-perceptions and values (ES=0.49, p<0.001), quality of life (ES=0.457, p=0.001), cognitive skills (ES=0.428, p<0.001), social skills (ES=0.371, p<0.001), physical health (ES=0.285, p<0.001), sexual health (ES=0.257, p=0.017), academic/occupational performance (ES=0.211, p<0.001) and attitude towards mental disorders (ES=0.177, p=0.006). Psychoeducation was the most effective intervention for promoting mental health literacy (ES=0.774, p<0.001) and cognitive skills (ES=1.153, p=0.03). Physical therapy, exercise and relaxation were more effective than psychoeducation and psychotherapy for promoting physical health (ES=0.498, p<0.001). In conclusion, several universal/selective interventions can be effective to promote good mental health in young people. Future research should consolidate and extend these findings.

Original language	English
Pages (from-to)	28-39
Number of pages	12
Journal	European Neuropsychopharmacology
Volume	41
DOIs	https://doi.org/10.1016/j.euroneuro.2020.10.007
Publication status	Published - 2020 Dec

Bibliographical note

Funding Information:
This study was supported by the European College of Neuropsychopharmacology Network Board. Dr Salazar de Pablo is supported by the Alicia Koplowitz Foundation. Dr Fusar-Poli is supported by the PSYSCAN project through the European Commission.

Funding Information:
Dr. Correll has been a consultant and/or advisor to or has received honoraria from: Alkermes, Allergan, Angelini, Boehringer-Ingelheim, Gedeon Richter, Gerson Lehrman Group, Indivior, IntraCellular Therapies, Janssen/J&J, LB Pharma, Lundbeck, MedAvante-ProPhase, Medscape, Merck, Neurocrine, Noven, Otsuka, Pfizer, Recordati, Rovi, Servier, Sumitomo Dainippon, Sunovion, Supernus, Takeda, and Teva. He has provided expert testimony for Bristol-Myers Squibb, Janssen, and Otsuka. He served on a Data Safety Monitoring Board for Boehringer-Ingelheim, Lundbeck, Rovi, Supernus, and Teva. He received royalties from UpToDate and grant support from Janssen and Takeda. He is also a stock option holder of LB Pharma. Dr. Kessing has been a consultant to or has received honoraria or grants from Lundbeck. Dr. Arango has been a consultant to or has received honoraria or grants from Acadia, Angelini, Gedeon Richter, Janssen Cilag, Lundbeck, Otsuka, Roche, Sage, Servier, Shire, Schering Plough, Sumitomo Dainippon Pharma, Sunovion and Takeda. Dr. Bechdolf has been a consultant and/or advisor to or has received honoraria or grants from: Janssen/J&J, LB Pharma, Lundbeck, Otsuka, Pfizer and Recordati. Dr Catalan has received personal fees from Janssen. Dr. Vieta has received grants and served as consultant, advisor or CME speaker for the following entities: Abbott, Allergan, Angelini, Dainippon Sumitomo Pharma, Janssen, Lundbeck, Novartis, Otsuka, Richter, Sage, Sanofi-Aventis, and Takeda. Dr Fusar-Poli has received grants from Lundbeck and personal fees from Menarini, Lundbeck and Angelini. No other disclosures were reported.

Publisher Copyright:
© 2020

All Science Journal Classification (ASJC) codes

Pharmacology
Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.euroneuro.2020.10.007

Cite this

Salazar de Pablo, G., De Micheli, A., Nieman, D. H., Correll, C. U., Kessing, L. V., Pfennig, A., Bechdolf, A., Borgwardt, S., Arango, C., van Amelsvoort, T., Vieta, E., Solmi, M., Oliver, D., Catalan, A., Verdino, V., Di Maggio, L., Bonoldi, I., Vaquerizo-Serrano, J., Baccaredda Boy, O., ... Fusar-Poli, P. (2020). Universal and selective interventions to promote good mental health in young people: Systematic review and meta-analysis. European Neuropsychopharmacology, 41, 28-39. https://doi.org/10.1016/j.euroneuro.2020.10.007

@article{15227f4db0404a359844d7391f58e013,

title = "Universal and selective interventions to promote good mental health in young people: Systematic review and meta-analysis",

abstract = "Promotion of good mental health in young people is important. Our aim was to evaluate the consistency and magnitude of the efficacy of universal/selective interventions to promote good mental health. A systematic PRISMA/RIGHT-compliant meta-analysis (PROSPERO: CRD42018088708) search of Web of Science until 04/31/2019 identified original studies comparing the efficacy of universal/selective interventions for good mental health vs a control group, in samples with a mean age <35 years. Meta-analytical random-effects model, heterogeneity statistics, assessment of publication bias, study quality and sensitivity analyses investigated the efficacy (Hedges{\textquoteright} g=effect size, ES) of universal/selective interventions to promote 14 good mental health outcomes defined a-priori. 276 studies were included (total participants: 159,508, 79,142 interventions and 80,366 controls), mean age=15.0 (SD=7.4); female=56.0%. There was a significant overall improvement in 10/13 good mental health outcome categories that could be meta-analysed: compared to controls, interventions significantly improved (in descending order of magnitude) mental health literacy (ES=0.685, p<0.001), emotions (ES=0.541, p<0.001), self-perceptions and values (ES=0.49, p<0.001), quality of life (ES=0.457, p=0.001), cognitive skills (ES=0.428, p<0.001), social skills (ES=0.371, p<0.001), physical health (ES=0.285, p<0.001), sexual health (ES=0.257, p=0.017), academic/occupational performance (ES=0.211, p<0.001) and attitude towards mental disorders (ES=0.177, p=0.006). Psychoeducation was the most effective intervention for promoting mental health literacy (ES=0.774, p<0.001) and cognitive skills (ES=1.153, p=0.03). Physical therapy, exercise and relaxation were more effective than psychoeducation and psychotherapy for promoting physical health (ES=0.498, p<0.001). In conclusion, several universal/selective interventions can be effective to promote good mental health in young people. Future research should consolidate and extend these findings.",

author = "{Salazar de Pablo}, Gonzalo and {De Micheli}, Andrea and Nieman, {Dorien H.} and Correll, {Christoph U.} and Kessing, {Lars Vedel} and Andrea Pfennig and Andreas Bechdolf and Stefan Borgwardt and Celso Arango and {van Amelsvoort}, Therese and Eduard Vieta and Marco Solmi and Dominic Oliver and Ana Catalan and Valeria Verdino and {Di Maggio}, Lucia and Ilaria Bonoldi and Julio Vaquerizo-Serrano and {Baccaredda Boy}, Ottone and Umberto Provenzani and Francesca Ruzzi and Federica Calorio and Guido Nosari and {Di Marco}, Benedetto and Irene Famularo and Silvia Molteni and Eleonora Filosi and Martina Mensi and Umberto Balottin and Pierluigi Politi and Shin, {Jae Il} and Paolo Fusar-Poli",

note = "Funding Information: This study was supported by the European College of Neuropsychopharmacology Network Board. Dr Salazar de Pablo is supported by the Alicia Koplowitz Foundation. Dr Fusar-Poli is supported by the PSYSCAN project through the European Commission. Funding Information: Dr. Correll has been a consultant and/or advisor to or has received honoraria from: Alkermes, Allergan, Angelini, Boehringer-Ingelheim, Gedeon Richter, Gerson Lehrman Group, Indivior, IntraCellular Therapies, Janssen/J&J, LB Pharma, Lundbeck, MedAvante-ProPhase, Medscape, Merck, Neurocrine, Noven, Otsuka, Pfizer, Recordati, Rovi, Servier, Sumitomo Dainippon, Sunovion, Supernus, Takeda, and Teva. He has provided expert testimony for Bristol-Myers Squibb, Janssen, and Otsuka. He served on a Data Safety Monitoring Board for Boehringer-Ingelheim, Lundbeck, Rovi, Supernus, and Teva. He received royalties from UpToDate and grant support from Janssen and Takeda. He is also a stock option holder of LB Pharma. Dr. Kessing has been a consultant to or has received honoraria or grants from Lundbeck. Dr. Arango has been a consultant to or has received honoraria or grants from Acadia, Angelini, Gedeon Richter, Janssen Cilag, Lundbeck, Otsuka, Roche, Sage, Servier, Shire, Schering Plough, Sumitomo Dainippon Pharma, Sunovion and Takeda. Dr. Bechdolf has been a consultant and/or advisor to or has received honoraria or grants from: Janssen/J&J, LB Pharma, Lundbeck, Otsuka, Pfizer and Recordati. Dr Catalan has received personal fees from Janssen. Dr. Vieta has received grants and served as consultant, advisor or CME speaker for the following entities: Abbott, Allergan, Angelini, Dainippon Sumitomo Pharma, Janssen, Lundbeck, Novartis, Otsuka, Richter, Sage, Sanofi-Aventis, and Takeda. Dr Fusar-Poli has received grants from Lundbeck and personal fees from Menarini, Lundbeck and Angelini. No other disclosures were reported. Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = dec,

doi = "10.1016/j.euroneuro.2020.10.007",

language = "English",

volume = "41",

pages = "28--39",

journal = "European Neuropsychopharmacology",

issn = "0924-977X",

publisher = "Elsevier",

}

Salazar de Pablo, G, De Micheli, A, Nieman, DH, Correll, CU, Kessing, LV, Pfennig, A, Bechdolf, A, Borgwardt, S, Arango, C, van Amelsvoort, T, Vieta, E, Solmi, M, Oliver, D, Catalan, A, Verdino, V, Di Maggio, L, Bonoldi, I, Vaquerizo-Serrano, J, Baccaredda Boy, O, Provenzani, U, Ruzzi, F, Calorio, F, Nosari, G, Di Marco, B, Famularo, I, Molteni, S, Filosi, E, Mensi, M, Balottin, U, Politi, P, Shin, JI & Fusar-Poli, P 2020, 'Universal and selective interventions to promote good mental health in young people: Systematic review and meta-analysis', European Neuropsychopharmacology, vol. 41, pp. 28-39. https://doi.org/10.1016/j.euroneuro.2020.10.007

TY - JOUR

T1 - Universal and selective interventions to promote good mental health in young people

T2 - Systematic review and meta-analysis

AU - Salazar de Pablo, Gonzalo

AU - De Micheli, Andrea

AU - Nieman, Dorien H.

AU - Correll, Christoph U.

AU - Kessing, Lars Vedel

AU - Pfennig, Andrea

AU - Bechdolf, Andreas

AU - Borgwardt, Stefan

AU - Arango, Celso

AU - van Amelsvoort, Therese

AU - Vieta, Eduard

AU - Solmi, Marco

AU - Oliver, Dominic

AU - Catalan, Ana

AU - Verdino, Valeria

AU - Di Maggio, Lucia

AU - Bonoldi, Ilaria

AU - Vaquerizo-Serrano, Julio

AU - Baccaredda Boy, Ottone

AU - Provenzani, Umberto

AU - Ruzzi, Francesca

AU - Calorio, Federica

AU - Nosari, Guido

AU - Di Marco, Benedetto

AU - Famularo, Irene

AU - Molteni, Silvia

AU - Filosi, Eleonora

AU - Mensi, Martina

AU - Balottin, Umberto

AU - Politi, Pierluigi

AU - Shin, Jae Il

AU - Fusar-Poli, Paolo

N1 - Funding Information: This study was supported by the European College of Neuropsychopharmacology Network Board. Dr Salazar de Pablo is supported by the Alicia Koplowitz Foundation. Dr Fusar-Poli is supported by the PSYSCAN project through the European Commission. Funding Information: Dr. Correll has been a consultant and/or advisor to or has received honoraria from: Alkermes, Allergan, Angelini, Boehringer-Ingelheim, Gedeon Richter, Gerson Lehrman Group, Indivior, IntraCellular Therapies, Janssen/J&J, LB Pharma, Lundbeck, MedAvante-ProPhase, Medscape, Merck, Neurocrine, Noven, Otsuka, Pfizer, Recordati, Rovi, Servier, Sumitomo Dainippon, Sunovion, Supernus, Takeda, and Teva. He has provided expert testimony for Bristol-Myers Squibb, Janssen, and Otsuka. He served on a Data Safety Monitoring Board for Boehringer-Ingelheim, Lundbeck, Rovi, Supernus, and Teva. He received royalties from UpToDate and grant support from Janssen and Takeda. He is also a stock option holder of LB Pharma. Dr. Kessing has been a consultant to or has received honoraria or grants from Lundbeck. Dr. Arango has been a consultant to or has received honoraria or grants from Acadia, Angelini, Gedeon Richter, Janssen Cilag, Lundbeck, Otsuka, Roche, Sage, Servier, Shire, Schering Plough, Sumitomo Dainippon Pharma, Sunovion and Takeda. Dr. Bechdolf has been a consultant and/or advisor to or has received honoraria or grants from: Janssen/J&J, LB Pharma, Lundbeck, Otsuka, Pfizer and Recordati. Dr Catalan has received personal fees from Janssen. Dr. Vieta has received grants and served as consultant, advisor or CME speaker for the following entities: Abbott, Allergan, Angelini, Dainippon Sumitomo Pharma, Janssen, Lundbeck, Novartis, Otsuka, Richter, Sage, Sanofi-Aventis, and Takeda. Dr Fusar-Poli has received grants from Lundbeck and personal fees from Menarini, Lundbeck and Angelini. No other disclosures were reported. Publisher Copyright: © 2020

PY - 2020/12

Y1 - 2020/12

N2 - Promotion of good mental health in young people is important. Our aim was to evaluate the consistency and magnitude of the efficacy of universal/selective interventions to promote good mental health. A systematic PRISMA/RIGHT-compliant meta-analysis (PROSPERO: CRD42018088708) search of Web of Science until 04/31/2019 identified original studies comparing the efficacy of universal/selective interventions for good mental health vs a control group, in samples with a mean age <35 years. Meta-analytical random-effects model, heterogeneity statistics, assessment of publication bias, study quality and sensitivity analyses investigated the efficacy (Hedges’ g=effect size, ES) of universal/selective interventions to promote 14 good mental health outcomes defined a-priori. 276 studies were included (total participants: 159,508, 79,142 interventions and 80,366 controls), mean age=15.0 (SD=7.4); female=56.0%. There was a significant overall improvement in 10/13 good mental health outcome categories that could be meta-analysed: compared to controls, interventions significantly improved (in descending order of magnitude) mental health literacy (ES=0.685, p<0.001), emotions (ES=0.541, p<0.001), self-perceptions and values (ES=0.49, p<0.001), quality of life (ES=0.457, p=0.001), cognitive skills (ES=0.428, p<0.001), social skills (ES=0.371, p<0.001), physical health (ES=0.285, p<0.001), sexual health (ES=0.257, p=0.017), academic/occupational performance (ES=0.211, p<0.001) and attitude towards mental disorders (ES=0.177, p=0.006). Psychoeducation was the most effective intervention for promoting mental health literacy (ES=0.774, p<0.001) and cognitive skills (ES=1.153, p=0.03). Physical therapy, exercise and relaxation were more effective than psychoeducation and psychotherapy for promoting physical health (ES=0.498, p<0.001). In conclusion, several universal/selective interventions can be effective to promote good mental health in young people. Future research should consolidate and extend these findings.

AB - Promotion of good mental health in young people is important. Our aim was to evaluate the consistency and magnitude of the efficacy of universal/selective interventions to promote good mental health. A systematic PRISMA/RIGHT-compliant meta-analysis (PROSPERO: CRD42018088708) search of Web of Science until 04/31/2019 identified original studies comparing the efficacy of universal/selective interventions for good mental health vs a control group, in samples with a mean age <35 years. Meta-analytical random-effects model, heterogeneity statistics, assessment of publication bias, study quality and sensitivity analyses investigated the efficacy (Hedges’ g=effect size, ES) of universal/selective interventions to promote 14 good mental health outcomes defined a-priori. 276 studies were included (total participants: 159,508, 79,142 interventions and 80,366 controls), mean age=15.0 (SD=7.4); female=56.0%. There was a significant overall improvement in 10/13 good mental health outcome categories that could be meta-analysed: compared to controls, interventions significantly improved (in descending order of magnitude) mental health literacy (ES=0.685, p<0.001), emotions (ES=0.541, p<0.001), self-perceptions and values (ES=0.49, p<0.001), quality of life (ES=0.457, p=0.001), cognitive skills (ES=0.428, p<0.001), social skills (ES=0.371, p<0.001), physical health (ES=0.285, p<0.001), sexual health (ES=0.257, p=0.017), academic/occupational performance (ES=0.211, p<0.001) and attitude towards mental disorders (ES=0.177, p=0.006). Psychoeducation was the most effective intervention for promoting mental health literacy (ES=0.774, p<0.001) and cognitive skills (ES=1.153, p=0.03). Physical therapy, exercise and relaxation were more effective than psychoeducation and psychotherapy for promoting physical health (ES=0.498, p<0.001). In conclusion, several universal/selective interventions can be effective to promote good mental health in young people. Future research should consolidate and extend these findings.

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DO - 10.1016/j.euroneuro.2020.10.007

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SN - 0924-977X

VL - 41

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JF - European Neuropsychopharmacology

ER -

Universal and selective interventions to promote good mental health in young people: Systematic review and meta-analysis

Abstract

Bibliographical note

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UN SDGs

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