Background/Aims: Limited data are available regarding psychosocial distress at the time of diagnosis of ulcerative colitis (UC). We investigated the psychosocial burden and factors related to poor health-related quality of life (HRQL) among patients newly diagnosed with moderate-to-severe UC who were affiliated with the nationwide prospective cohort study. Methods: Within the first 4 weeks of UC diagnosis, all patients were assessed using the Hospital Anxiety and Depression Scale (HADS), Work Productivity and Activity Impairment questionnaire, Inflammatory Bowel Disease Questionnaire (IBDQ), and 12-Item Short Form (SF-12) health survey. A multiple linear regression model was used to identify factors associated with HRQL. Results: Between August 2014 and February 2017, 355 patients completed questionnaires. Significant mood disorders requiring psychological interventions, defined by a HADS score ≥11, were identified in 16.7% (anxiety) and 20.6% (depression) of patients. Patients with severe disease were more likely to have presenteeism, loss of work productivity, and activity loss than those with moderate disease (all p<0.05). Significant mood disorders had the strongest negative relationship with total IBDQ score, which indicates disease-specific HRQL (β coefficient: -22.1 for depression and -40.0 for anxiety, p<0.001). The scores of all SF-12 dimensions, which indicate general HRQL, were remarkably decreased in the study population compared indirectly with previously reported scores in the general population. The Mayo score, C-reactive protein level, and white blood cell count showed significant negative associations with the IBDQ score (p<0.05). Conclusions: Psychosocial screening and timely interventions should be incorporated into the initial care of patients newly diagnosed with UC.
Bibliographical noteFunding Information:
This work was supported by Janssen Korea. No other potential conflict of interest relevant to this article was reported.
The authors acknowledge and would like to thank the following members of the moderate-to-severe ulcerative colitis in Korea (MOSAIK) study group for participating in the study: Yoon Jae Kim, Gachon University Gil Medical Center, Incheon; Tae Oh Kim, Inje University College of Medicine, Busan; Geom Seog Seo, Wonkwang University School of Medicine, Iksan; Ja Seol Koo, Korea University College of Medicine, Seoul; Joo Sung Kim, Seoul National University College of Medicine, Seoul; Byung Ik Jang, Yeungnam University College of Medicine, Dae-gu; Jeong Eun Shin, Dankook University College of Medicine, Cheonan; Ji Won Kim, Seoul National University Boramae Hospital, Seoul; Young Su Park, Seoul National University Bundang Hospital, Seongnam; YoungJa Lee, Medical Affairs, Janssen Korea, Seoul, Korea. This work was supported by Janssen Korea.
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