Unraveling the structured solvation shell of zwitterion nanoparticles for controlled release of nitric oxide

Sungwon Jung, Kyungtae Park, Sohyeon Park, Jiwoong Heo, Woojin Choi, Jinkee Hong

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Zwitterions have been attracting emerging attention as an anti-fouling polymer. However, the relationship between structured solvation shells and controlled drug release induced by deceleration of water molecule's translational and vibrational motions of zwitterions is an uncharted territory. Herein, sulfobetaine zwitterion nanoparticles (ZWNPs) were designed as a stable nitric oxide (NO)-delivering carrier. The condensed water structure of the solvation shell at its isoelectric point (PI) and the loose structure of water under different pH conditions were investigated through rheological and thermodynamical analyses. The ZWNPs showed a sustained-release profile at the PI, which presented a structured solvation barrier. On the other hand, NO-loaded ZWNPs showed different release profiles with the burst release at pH 5.5. Notably, an increased cell proliferation rate and a decreased antibacterial effect were observed at the same concentration depending on solvation shell's characteristics.

Original languageEnglish
Pages (from-to)54363-54374
Number of pages12
JournalACS Applied Materials and Interfaces
Issue number45
Publication statusPublished - 2021 Nov 17

Bibliographical note

Funding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2017R1E1A1A01074343), Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science & ICT (2019M3A9H110378611), the Korea Medical Device Development Fund grant provided by the Korea Government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, Republic of Korea, and the Ministry of Food and Drug Safety) (project Number: 202011D04), and the Korea Environment Industry & Technology Institute (KEITI) through Ecological Imitation-based Environmental Pollution Management Technology Development Project which was funded by the Korea Ministry of Environment (MOE) (2019002790001).

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All Science Journal Classification (ASJC) codes

  • Materials Science(all)


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