Unrecognized kinetics of serum testosterone

Impact on short-term androgen deprivation therapy for prostate cancer

Kyo Chul Koo, Dong Hoon Lee, Kyu Hyun Kim, Seung Hwan Lee, Chang Hee Hong, Sung Joon Hong, Byungha Chung

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: To evaluate the kinetics of serum testosterone (T) recovery following short-term androgen deprivation therapy (ADT), as the understanding thereof is essential for the proper management of prostate cancer (PCa), especially intermittent ADT. Materials and Methods: This prospective analysis included male sex offenders who voluntarily received leuprolide acetate in order to alleviate sexual aberrance. Thirty-three and 25 patients who received 3 and 6 months of ADT were assigned to Group A and Group B, respectively. Serum T levels were obtained every week during the on-cycle period, then monthly during the off-cycle period for at least 12 months. Results: The kinetics of serum T during the on-cycle period were similar in both groups. After flare reaction at week 2, a nadir of 0.45±0.29 ng/mL was achieved. In Group A, an abrupt rebound-upsurge was observed during the first 2 month off-cycle period, which surpassed the baseline level and reached a plateau level of 8.74±2.11 ng/mL during the flare (p<0.001). This upsurge was followed by a gradual decline back to baseline over the following 10 months. In Group B, a gradual increase was observed, and a baseline level of 7.26±1.73 ng/mL was reached at 5 months. Thereafter, an ongoing upsurge that surpassed baseline levels was observed until 12 months (8.81±1.92 ng/mL; p=0.002). Conclusion: The kinetics of serum T recovery during the off-cycle period varied according to the duration of ADT. Serum T should be monitored beyond normalization, as an excessive rebound may improve quality-of-life, but hamper the treatment efficacy of PCa.

Original languageEnglish
Pages (from-to)570-575
Number of pages6
JournalYonsei medical journal
Volume55
Issue number3
DOIs
Publication statusPublished - 2014 Jan 1

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Androgens
Testosterone
Prostatic Neoplasms
Serum
Leuprolide
Therapeutics
Quality of Life

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Koo, Kyo Chul ; Lee, Dong Hoon ; Kim, Kyu Hyun ; Lee, Seung Hwan ; Hong, Chang Hee ; Hong, Sung Joon ; Chung, Byungha. / Unrecognized kinetics of serum testosterone : Impact on short-term androgen deprivation therapy for prostate cancer. In: Yonsei medical journal. 2014 ; Vol. 55, No. 3. pp. 570-575.
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abstract = "Purpose: To evaluate the kinetics of serum testosterone (T) recovery following short-term androgen deprivation therapy (ADT), as the understanding thereof is essential for the proper management of prostate cancer (PCa), especially intermittent ADT. Materials and Methods: This prospective analysis included male sex offenders who voluntarily received leuprolide acetate in order to alleviate sexual aberrance. Thirty-three and 25 patients who received 3 and 6 months of ADT were assigned to Group A and Group B, respectively. Serum T levels were obtained every week during the on-cycle period, then monthly during the off-cycle period for at least 12 months. Results: The kinetics of serum T during the on-cycle period were similar in both groups. After flare reaction at week 2, a nadir of 0.45±0.29 ng/mL was achieved. In Group A, an abrupt rebound-upsurge was observed during the first 2 month off-cycle period, which surpassed the baseline level and reached a plateau level of 8.74±2.11 ng/mL during the flare (p<0.001). This upsurge was followed by a gradual decline back to baseline over the following 10 months. In Group B, a gradual increase was observed, and a baseline level of 7.26±1.73 ng/mL was reached at 5 months. Thereafter, an ongoing upsurge that surpassed baseline levels was observed until 12 months (8.81±1.92 ng/mL; p=0.002). Conclusion: The kinetics of serum T recovery during the off-cycle period varied according to the duration of ADT. Serum T should be monitored beyond normalization, as an excessive rebound may improve quality-of-life, but hamper the treatment efficacy of PCa.",
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Unrecognized kinetics of serum testosterone : Impact on short-term androgen deprivation therapy for prostate cancer. / Koo, Kyo Chul; Lee, Dong Hoon; Kim, Kyu Hyun; Lee, Seung Hwan; Hong, Chang Hee; Hong, Sung Joon; Chung, Byungha.

In: Yonsei medical journal, Vol. 55, No. 3, 01.01.2014, p. 570-575.

Research output: Contribution to journalArticle

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AU - Lee, Dong Hoon

AU - Kim, Kyu Hyun

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AU - Hong, Chang Hee

AU - Hong, Sung Joon

AU - Chung, Byungha

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N2 - Purpose: To evaluate the kinetics of serum testosterone (T) recovery following short-term androgen deprivation therapy (ADT), as the understanding thereof is essential for the proper management of prostate cancer (PCa), especially intermittent ADT. Materials and Methods: This prospective analysis included male sex offenders who voluntarily received leuprolide acetate in order to alleviate sexual aberrance. Thirty-three and 25 patients who received 3 and 6 months of ADT were assigned to Group A and Group B, respectively. Serum T levels were obtained every week during the on-cycle period, then monthly during the off-cycle period for at least 12 months. Results: The kinetics of serum T during the on-cycle period were similar in both groups. After flare reaction at week 2, a nadir of 0.45±0.29 ng/mL was achieved. In Group A, an abrupt rebound-upsurge was observed during the first 2 month off-cycle period, which surpassed the baseline level and reached a plateau level of 8.74±2.11 ng/mL during the flare (p<0.001). This upsurge was followed by a gradual decline back to baseline over the following 10 months. In Group B, a gradual increase was observed, and a baseline level of 7.26±1.73 ng/mL was reached at 5 months. Thereafter, an ongoing upsurge that surpassed baseline levels was observed until 12 months (8.81±1.92 ng/mL; p=0.002). Conclusion: The kinetics of serum T recovery during the off-cycle period varied according to the duration of ADT. Serum T should be monitored beyond normalization, as an excessive rebound may improve quality-of-life, but hamper the treatment efficacy of PCa.

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