Unshielding Exosomal RNA Unleashes Tumor Growth And Metastasis

Irina Matei, Han Sang Kim, David Lyden

Research output: Contribution to journalShort surveypeer-review

27 Citations (Scopus)

Abstract

Reciprocal interactions between tumor cells and their microenvironment drive cancer progression and therapy resistance. In this issue, Nabet et al. demonstrate that dynamic feedback between tumor and stroma subverts normal inflammatory responses by triggering the release of exosomes containing unshielded RNAs that activate pattern recognition receptors, thereby promoting tumor growth and metastasis.

Original languageEnglish
Pages (from-to)223-225
Number of pages3
JournalCell
Volume170
Issue number2
DOIs
Publication statusPublished - 2017 Jul 13

Bibliographical note

Publisher Copyright:
© 2017

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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