Unshielding Exosomal RNA Unleashes Tumor Growth And Metastasis

Irina Matei; Han Sang Kim; David Lyden

doi:10.1016/j.cell.2017.06.047

Unshielding Exosomal RNA Unleashes Tumor Growth And Metastasis

Irina Matei, Han Sang Kim, David Lyden

Department of Internal Medicine

Research output: Contribution to journal › Short survey › peer-review

31 Citations (Scopus)

Abstract

Reciprocal interactions between tumor cells and their microenvironment drive cancer progression and therapy resistance. In this issue, Nabet et al. demonstrate that dynamic feedback between tumor and stroma subverts normal inflammatory responses by triggering the release of exosomes containing unshielded RNAs that activate pattern recognition receptors, thereby promoting tumor growth and metastasis.

Original language	English
Pages (from-to)	223-225
Number of pages	3
Journal	Cell
Volume	170
Issue number	2
DOIs	https://doi.org/10.1016/j.cell.2017.06.047
Publication status	Published - 2017 Jul 13

Bibliographical note

Publisher Copyright:
© 2017

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.cell.2017.06.047

Cite this

@article{486d38ba6a5146a6830cacd0ab94397c,

title = "Unshielding Exosomal RNA Unleashes Tumor Growth And Metastasis",

abstract = "Reciprocal interactions between tumor cells and their microenvironment drive cancer progression and therapy resistance. In this issue, Nabet et al. demonstrate that dynamic feedback between tumor and stroma subverts normal inflammatory responses by triggering the release of exosomes containing unshielded RNAs that activate pattern recognition receptors, thereby promoting tumor growth and metastasis.",

author = "Irina Matei and Kim, {Han Sang} and David Lyden",

note = "Publisher Copyright: {\textcopyright} 2017",

year = "2017",

month = jul,

day = "13",

doi = "10.1016/j.cell.2017.06.047",

language = "English",

volume = "170",

pages = "223--225",

journal = "Cell",

issn = "0092-8674",

publisher = "Cell Press",

number = "2",

}

TY - JOUR

T1 - Unshielding Exosomal RNA Unleashes Tumor Growth And Metastasis

AU - Matei, Irina

AU - Kim, Han Sang

AU - Lyden, David

PY - 2017/7/13

Y1 - 2017/7/13

N2 - Reciprocal interactions between tumor cells and their microenvironment drive cancer progression and therapy resistance. In this issue, Nabet et al. demonstrate that dynamic feedback between tumor and stroma subverts normal inflammatory responses by triggering the release of exosomes containing unshielded RNAs that activate pattern recognition receptors, thereby promoting tumor growth and metastasis.

AB - Reciprocal interactions between tumor cells and their microenvironment drive cancer progression and therapy resistance. In this issue, Nabet et al. demonstrate that dynamic feedback between tumor and stroma subverts normal inflammatory responses by triggering the release of exosomes containing unshielded RNAs that activate pattern recognition receptors, thereby promoting tumor growth and metastasis.

UR - http://www.scopus.com/inward/record.url?scp=85023620976&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85023620976&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2017.06.047

DO - 10.1016/j.cell.2017.06.047

M3 - Short survey

C2 - 28708994

AN - SCOPUS:85023620976

SN - 0092-8674

VL - 170

SP - 223

EP - 225

JO - Cell

JF - Cell

IS - 2

ER -

Unshielding Exosomal RNA Unleashes Tumor Growth And Metastasis

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this