Untargeted metabolomics and polyamine profiling in serum before and after surgery in colorectal cancer patients

Yu Ra Lee, Ki Yong An, Justin Jeon, Nam Kyu Kim, Ji Won Lee, Jongki Hong, Bong Chul Chung

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Colorectal cancer is one of the most prevalent cancers in Korea and globally. In this study, we aimed to characterize the differential serum metabolomic profiles between pre-operative and post-operative patients with colorectal cancer. To investigate the significant metabolites and metabolic pathways associated with colorectal cancer, we analyzed serum samples from 68 patients (aged 20–71, mean 57.57 years). Untargeted and targeted metabolomics profiling in patients with colorectal cancer were performed using liquid chromatography-mass spectrometry. Untargeted analysis identified differences in sphingolipid metabolism, steroid biosynthesis, and arginine and proline metabolism in pre-and post-operative patients with colorectal cancer. We then performed quantitative target profiling of polyamines, synthesized from arginine and proline metabolism, to identify potential polyamines that may serve as effective biomarkers for colorectal cancer. Results indicate a significantly reduced serum concentration of putrescine in post-operative patients compared to pre-operative patients. Our metabolomics approach provided insights into the physiological alterations in patients with colorectal cancer after surgery.

Original languageEnglish
Article number487
Pages (from-to)1-12
Number of pages12
JournalMetabolites
Volume10
Issue number12
DOIs
Publication statusPublished - 2020 Dec

Bibliographical note

Funding Information:
Funding: This research was funded by Korea Institute of Science and Technology Institutional Program (Grant No. 2E30480).

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Biology

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