Unusual cortical involvement in aquaporin-4 antibody-positive patients: An analysis with double inversion recovery and phase-sensitive inversion recovery imaging

Seung Woo Kim, Ho Joon Lee, Seung Min Kim, Young Chul Choi, Ha Young Shin

Research output: Contribution to journalArticle

Abstract

Background: : Previous studies strongly suggested the absence of cortical involvement in neuromyelitis optica spectrum disorder. Methods: : We describe two patients with anti-aquaporin-4 antibody and cortical lesions. Results: : A 58-year-old and a 61-year-old woman presented with status epilepticus and right leg numbness, respectively. Double inversion recovery (DIR) and phase-sensitive inversion recovery (PSIR) imaging, magnetic resonance imaging sequences that enable the clear delineation of gray matter, revealed intracortical lesions and lesions located across the cortex and subcortex. Conclusion: : Although rare, cortical involvement may exist in aquaporin-4 antibody-positive patients. DIR and PSIR MRI can help to determine the exact location of the lesion.

Original languageEnglish
Pages (from-to)283-285
Number of pages3
JournalMultiple Sclerosis and Related Disorders
Volume28
DOIs
Publication statusPublished - 2019 Feb

Fingerprint

Aquaporin 4
Neuromyelitis Optica
Hypesthesia
Antibodies
Status Epilepticus
Leg
Magnetic Resonance Imaging
Gray Matter

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

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title = "Unusual cortical involvement in aquaporin-4 antibody-positive patients: An analysis with double inversion recovery and phase-sensitive inversion recovery imaging",
abstract = "Background: : Previous studies strongly suggested the absence of cortical involvement in neuromyelitis optica spectrum disorder. Methods: : We describe two patients with anti-aquaporin-4 antibody and cortical lesions. Results: : A 58-year-old and a 61-year-old woman presented with status epilepticus and right leg numbness, respectively. Double inversion recovery (DIR) and phase-sensitive inversion recovery (PSIR) imaging, magnetic resonance imaging sequences that enable the clear delineation of gray matter, revealed intracortical lesions and lesions located across the cortex and subcortex. Conclusion: : Although rare, cortical involvement may exist in aquaporin-4 antibody-positive patients. DIR and PSIR MRI can help to determine the exact location of the lesion.",
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Unusual cortical involvement in aquaporin-4 antibody-positive patients : An analysis with double inversion recovery and phase-sensitive inversion recovery imaging. / Kim, Seung Woo; Lee, Ho Joon; Kim, Seung Min; Choi, Young Chul; Shin, Ha Young.

In: Multiple Sclerosis and Related Disorders, Vol. 28, 02.2019, p. 283-285.

Research output: Contribution to journalArticle

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T1 - Unusual cortical involvement in aquaporin-4 antibody-positive patients

T2 - An analysis with double inversion recovery and phase-sensitive inversion recovery imaging

AU - Kim, Seung Woo

AU - Lee, Ho Joon

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AB - Background: : Previous studies strongly suggested the absence of cortical involvement in neuromyelitis optica spectrum disorder. Methods: : We describe two patients with anti-aquaporin-4 antibody and cortical lesions. Results: : A 58-year-old and a 61-year-old woman presented with status epilepticus and right leg numbness, respectively. Double inversion recovery (DIR) and phase-sensitive inversion recovery (PSIR) imaging, magnetic resonance imaging sequences that enable the clear delineation of gray matter, revealed intracortical lesions and lesions located across the cortex and subcortex. Conclusion: : Although rare, cortical involvement may exist in aquaporin-4 antibody-positive patients. DIR and PSIR MRI can help to determine the exact location of the lesion.

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