Unusual O-conjugate addition reactions of β-ketoesters and 1,3-diketones to ethyl propynoate: Applications to the synthesis of furans

Jinsung Tae, Kwang Ok Kim

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Divinyl ethers were synthesized from 1,3-dicarbonyl compounds. Reactions of β-ketoesters and 1,3-diketones with ethyl propynoate in the presence of N-methylmorpholine produced unusual O-conjugate addition products in good yields. The divinyl ethers derived from 1,3-diketones were utilized for the synthesis of 2,3,5-trisubstituted furans under the standard radical cyclization conditions.

Original languageEnglish
Pages (from-to)2125-2128
Number of pages4
JournalTetrahedron Letters
Volume44
Issue number10
DOIs
Publication statusPublished - 2003 Mar 3

Bibliographical note

Funding Information:
This work was supported by Korea Research Foundation Grant (KRF-2002-003-C00080).

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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