Upregulation of long noncoding RNA LOC100507661 promotes tumor aggressiveness in thyroid cancer

Daham Kim, Woo Kyung Lee, Seonhyang Jeong, Mi Youn Seol, Hyunji Kim, Kyung Sup Kim, Eunjig Lee, Jandee Lee, Young Suk Jo

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Recent advances in next-generation sequencing have revealed a variety of long noncoding RNAs (lncRNAs). However, studies of lncRNAs are at a very early stage, our knowledge of the biological functions and clinical implications remains limited. To investigate the roles of lncRNAs in thyroid cancers, we verified 56 lncRNAs identified as potential cancer-promoting genes in a previous study that analyzed 2394 tumor SNP arrays from 12 types of cancer. Based on verified sequence information in NCBI and Ensembl, we ultimately selected three candidate lncRNAs for detailed analysis. One of the candidates, LOC100507661, was strongly upregulated in thyroid cancer tissues relative to paired contralateral normal tissue. LOC100507661 was easily detectable in papillary and anaplastic thyroid cancer cell lines such as TPC1, BCPAP, C643, and 8505C, but not in the follicular thyroid cancer cell line FTC133. Stable overexpression of LOC100507661 promoted cell proliferation, migration, and invasion of thyroid cancer cells. Lymph node metastasis and BRAF V600E mutations were more frequent in papillary thyroid cancers with high LOC100507661 expression. Our data demonstrate that LOC100507661 expression is elevated in human thyroid cancer and may play a critical role in thyroid carcinogenesis.

Original languageEnglish
Pages (from-to)36-45
Number of pages10
JournalMolecular and Cellular Endocrinology
Volume431
DOIs
Publication statusPublished - 2016 Aug 15

Fingerprint

Long Noncoding RNA
Thyroid Neoplasms
Tumors
Up-Regulation
Cells
Neoplasms
Tissue
Cell Line
Neoplasm Genes
Cell proliferation
Cell Movement
Single Nucleotide Polymorphism
Thyroid Gland
Carcinogenesis
Genes
Lymph Nodes
Cell Proliferation
Neoplasm Metastasis
Mutation

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Cite this

Kim, Daham ; Lee, Woo Kyung ; Jeong, Seonhyang ; Seol, Mi Youn ; Kim, Hyunji ; Kim, Kyung Sup ; Lee, Eunjig ; Lee, Jandee ; Jo, Young Suk. / Upregulation of long noncoding RNA LOC100507661 promotes tumor aggressiveness in thyroid cancer. In: Molecular and Cellular Endocrinology. 2016 ; Vol. 431. pp. 36-45.
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Upregulation of long noncoding RNA LOC100507661 promotes tumor aggressiveness in thyroid cancer. / Kim, Daham; Lee, Woo Kyung; Jeong, Seonhyang; Seol, Mi Youn; Kim, Hyunji; Kim, Kyung Sup; Lee, Eunjig; Lee, Jandee; Jo, Young Suk.

In: Molecular and Cellular Endocrinology, Vol. 431, 15.08.2016, p. 36-45.

Research output: Contribution to journalArticle

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