Urban-rural differences explain the association between serum 25-hydroxyvitamin D level and insulin resistance in Korea

Bo Mi Song, Yumie Rhee, Chang Oh Kim, Yoosik Youm, Kyoung Min Kim, Eun Young Lee, Ju Mi Lee, Young Mi Yoon, Hyeon Chang Kim

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Abstract

An increasing number of studies report associations between low serum 25-hydroxyvitamin D [25(OH)D] level and insulin resistance; however, whether low vitamin D levels directly contribute to increased insulin resistance is unclear. We investigated the impact of residential area on the association between 25(OH)D and insulin resistance in elderly Koreans. Using data from the Korean Urban Rural Elderly study, we conducted cross-sectional analyses in 1628 participants (505 men and 1123 women). Serum 25(OH)D was analyzed as both continuous and categorized variables. Homeostasis model assessment for insulin resistance (HOMA-IR) was calculated using fasting blood glucose and insulin levels. In men, 25(OH)D level was inversely associated with HOMA-IR (standardized β = −0.133, p < 0.001) after adjustment for age, body mass index, waist circumference, smoking, alcohol intake, exercise, and study year. However, we noted significant urban-rural differences in 25(OH)D level (43.4 versus 65.6 nmol/L; p < 0.001) and HOMA-IR (1.2 versus 0.8 mmol·pmol/L 2 ; p < 0.001). When we additionally adjusted for residential area, the association between 25(OH)D and HOMA-IR was attenuated (standardized β = −0.063, p = 0.115). In women, the association between 25(OH)D and HOMA-IR was not significant before or after adjustment for residential area. Environmental or lifestyle differences in urban and rural areas may largely explain the inverse association between serum 25(OH)D and insulin resistance.

Original languageEnglish
Pages (from-to)5806-5818
Number of pages13
JournalNutrients
Volume6
Issue number12
DOIs
Publication statusPublished - 2014 Dec 11

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Korea
insulin resistance
Korean Peninsula
Insulin Resistance
Serum
homeostasis
Homeostasis
residential areas
25-hydroxyvitamin D
waist circumference
Waist Circumference
vitamin D
Vitamin D
rural areas
urban areas
blood glucose
lifestyle
fasting
body mass index
Blood Glucose

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics

Cite this

Song, Bo Mi ; Rhee, Yumie ; Kim, Chang Oh ; Youm, Yoosik ; Kim, Kyoung Min ; Lee, Eun Young ; Lee, Ju Mi ; Yoon, Young Mi ; Kim, Hyeon Chang. / Urban-rural differences explain the association between serum 25-hydroxyvitamin D level and insulin resistance in Korea. In: Nutrients. 2014 ; Vol. 6, No. 12. pp. 5806-5818.
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Urban-rural differences explain the association between serum 25-hydroxyvitamin D level and insulin resistance in Korea. / Song, Bo Mi; Rhee, Yumie; Kim, Chang Oh; Youm, Yoosik; Kim, Kyoung Min; Lee, Eun Young; Lee, Ju Mi; Yoon, Young Mi; Kim, Hyeon Chang.

In: Nutrients, Vol. 6, No. 12, 11.12.2014, p. 5806-5818.

Research output: Contribution to journalArticle

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AU - Song, Bo Mi

AU - Rhee, Yumie

AU - Kim, Chang Oh

AU - Youm, Yoosik

AU - Kim, Kyoung Min

AU - Lee, Eun Young

AU - Lee, Ju Mi

AU - Yoon, Young Mi

AU - Kim, Hyeon Chang

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N2 - An increasing number of studies report associations between low serum 25-hydroxyvitamin D [25(OH)D] level and insulin resistance; however, whether low vitamin D levels directly contribute to increased insulin resistance is unclear. We investigated the impact of residential area on the association between 25(OH)D and insulin resistance in elderly Koreans. Using data from the Korean Urban Rural Elderly study, we conducted cross-sectional analyses in 1628 participants (505 men and 1123 women). Serum 25(OH)D was analyzed as both continuous and categorized variables. Homeostasis model assessment for insulin resistance (HOMA-IR) was calculated using fasting blood glucose and insulin levels. In men, 25(OH)D level was inversely associated with HOMA-IR (standardized β = −0.133, p < 0.001) after adjustment for age, body mass index, waist circumference, smoking, alcohol intake, exercise, and study year. However, we noted significant urban-rural differences in 25(OH)D level (43.4 versus 65.6 nmol/L; p < 0.001) and HOMA-IR (1.2 versus 0.8 mmol·pmol/L 2 ; p < 0.001). When we additionally adjusted for residential area, the association between 25(OH)D and HOMA-IR was attenuated (standardized β = −0.063, p = 0.115). In women, the association between 25(OH)D and HOMA-IR was not significant before or after adjustment for residential area. Environmental or lifestyle differences in urban and rural areas may largely explain the inverse association between serum 25(OH)D and insulin resistance.

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