Uric acid is associated with the rate of residual renal function decline in peritoneal dialysis patients

Jung Tak Park, Dong Ki Kim, Tae Ik Chang, Hyun Wook Kim, Jae Hyun Chang, Sun Young Park, Eunyoung Kim, Shin Wook Kang, Dae Suk Han, Tae Hyun Yoo

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Abstract

Background. Uric acid (UA) is known to play a pathogenic role in chronic kidney disease (CKD). However, its effect in end-stage renal disease (ESRD) has not yet been elucidated. We explored the prevalence of hyperuricaemia and the relationship between UA and residual renal function (RRF) in peritoneal dialysis (PD) patients.Methods. The subjects of this study were 134 PD patients who started dialysis at the Yonsei University Health System between January 2000 and December 2005. Timed urine collections were performed within 1 month of PD commencement and at 6-month intervals thereafter. The slope of decline of RRF over time was calculated by linear regression analysis of serial urinary urea and creatinine clearances for each patient. Biochemical and clinical data at the time of initial urine collection were considered as baseline.Results. At baseline, 32.8 of the PD patients had hyperuricaemia (UA ≥7.0 mgdl). A significant majority of patients with hyperuricaemia were diabetic (P = 0.02). Hypertensive patients had a higher UA level (P = 0.002) compared to normotensive patients. The overall reduction rate of RRF in hyperuricaemic patients was significantly higher than in the normouricaemic group (P = 0.001). In the multiple linear regression analysis, hyperuricaemia and history of DM showed a significant negative correlation with the reduction rate of RRF after adjusting for demographic data, comorbid conditions, body mass index, baseline RRF and medications (P = 0.001).Conclusions. Hyperuricaemia is common among PD patients and is significantly associated with the rate of decline of RRF.

Original languageEnglish
Pages (from-to)3520-3525
Number of pages6
JournalNephrology Dialysis Transplantation
Volume24
Issue number11
DOIs
Publication statusPublished - 2009 Nov 1

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Peritoneal Dialysis
Uric Acid
Kidney
Urine Specimen Collection
Linear Models
Regression Analysis
Chronic Renal Insufficiency
Chronic Kidney Failure
Urea
Dialysis
Creatinine
Body Mass Index
Demography
Health

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Transplantation

Cite this

Park, Jung Tak ; Kim, Dong Ki ; Chang, Tae Ik ; Kim, Hyun Wook ; Chang, Jae Hyun ; Park, Sun Young ; Kim, Eunyoung ; Kang, Shin Wook ; Han, Dae Suk ; Yoo, Tae Hyun. / Uric acid is associated with the rate of residual renal function decline in peritoneal dialysis patients. In: Nephrology Dialysis Transplantation. 2009 ; Vol. 24, No. 11. pp. 3520-3525.
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abstract = "Background. Uric acid (UA) is known to play a pathogenic role in chronic kidney disease (CKD). However, its effect in end-stage renal disease (ESRD) has not yet been elucidated. We explored the prevalence of hyperuricaemia and the relationship between UA and residual renal function (RRF) in peritoneal dialysis (PD) patients.Methods. The subjects of this study were 134 PD patients who started dialysis at the Yonsei University Health System between January 2000 and December 2005. Timed urine collections were performed within 1 month of PD commencement and at 6-month intervals thereafter. The slope of decline of RRF over time was calculated by linear regression analysis of serial urinary urea and creatinine clearances for each patient. Biochemical and clinical data at the time of initial urine collection were considered as baseline.Results. At baseline, 32.8 of the PD patients had hyperuricaemia (UA ≥7.0 mgdl). A significant majority of patients with hyperuricaemia were diabetic (P = 0.02). Hypertensive patients had a higher UA level (P = 0.002) compared to normotensive patients. The overall reduction rate of RRF in hyperuricaemic patients was significantly higher than in the normouricaemic group (P = 0.001). In the multiple linear regression analysis, hyperuricaemia and history of DM showed a significant negative correlation with the reduction rate of RRF after adjusting for demographic data, comorbid conditions, body mass index, baseline RRF and medications (P = 0.001).Conclusions. Hyperuricaemia is common among PD patients and is significantly associated with the rate of decline of RRF.",
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Uric acid is associated with the rate of residual renal function decline in peritoneal dialysis patients. / Park, Jung Tak; Kim, Dong Ki; Chang, Tae Ik; Kim, Hyun Wook; Chang, Jae Hyun; Park, Sun Young; Kim, Eunyoung; Kang, Shin Wook; Han, Dae Suk; Yoo, Tae Hyun.

In: Nephrology Dialysis Transplantation, Vol. 24, No. 11, 01.11.2009, p. 3520-3525.

Research output: Contribution to journalArticle

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T1 - Uric acid is associated with the rate of residual renal function decline in peritoneal dialysis patients

AU - Park, Jung Tak

AU - Kim, Dong Ki

AU - Chang, Tae Ik

AU - Kim, Hyun Wook

AU - Chang, Jae Hyun

AU - Park, Sun Young

AU - Kim, Eunyoung

AU - Kang, Shin Wook

AU - Han, Dae Suk

AU - Yoo, Tae Hyun

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Y1 - 2009/11/1

N2 - Background. Uric acid (UA) is known to play a pathogenic role in chronic kidney disease (CKD). However, its effect in end-stage renal disease (ESRD) has not yet been elucidated. We explored the prevalence of hyperuricaemia and the relationship between UA and residual renal function (RRF) in peritoneal dialysis (PD) patients.Methods. The subjects of this study were 134 PD patients who started dialysis at the Yonsei University Health System between January 2000 and December 2005. Timed urine collections were performed within 1 month of PD commencement and at 6-month intervals thereafter. The slope of decline of RRF over time was calculated by linear regression analysis of serial urinary urea and creatinine clearances for each patient. Biochemical and clinical data at the time of initial urine collection were considered as baseline.Results. At baseline, 32.8 of the PD patients had hyperuricaemia (UA ≥7.0 mgdl). A significant majority of patients with hyperuricaemia were diabetic (P = 0.02). Hypertensive patients had a higher UA level (P = 0.002) compared to normotensive patients. The overall reduction rate of RRF in hyperuricaemic patients was significantly higher than in the normouricaemic group (P = 0.001). In the multiple linear regression analysis, hyperuricaemia and history of DM showed a significant negative correlation with the reduction rate of RRF after adjusting for demographic data, comorbid conditions, body mass index, baseline RRF and medications (P = 0.001).Conclusions. Hyperuricaemia is common among PD patients and is significantly associated with the rate of decline of RRF.

AB - Background. Uric acid (UA) is known to play a pathogenic role in chronic kidney disease (CKD). However, its effect in end-stage renal disease (ESRD) has not yet been elucidated. We explored the prevalence of hyperuricaemia and the relationship between UA and residual renal function (RRF) in peritoneal dialysis (PD) patients.Methods. The subjects of this study were 134 PD patients who started dialysis at the Yonsei University Health System between January 2000 and December 2005. Timed urine collections were performed within 1 month of PD commencement and at 6-month intervals thereafter. The slope of decline of RRF over time was calculated by linear regression analysis of serial urinary urea and creatinine clearances for each patient. Biochemical and clinical data at the time of initial urine collection were considered as baseline.Results. At baseline, 32.8 of the PD patients had hyperuricaemia (UA ≥7.0 mgdl). A significant majority of patients with hyperuricaemia were diabetic (P = 0.02). Hypertensive patients had a higher UA level (P = 0.002) compared to normotensive patients. The overall reduction rate of RRF in hyperuricaemic patients was significantly higher than in the normouricaemic group (P = 0.001). In the multiple linear regression analysis, hyperuricaemia and history of DM showed a significant negative correlation with the reduction rate of RRF after adjusting for demographic data, comorbid conditions, body mass index, baseline RRF and medications (P = 0.001).Conclusions. Hyperuricaemia is common among PD patients and is significantly associated with the rate of decline of RRF.

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