Urinary ketone is associated with the heart failure severity

Ji Hyung Chung, Jin Sup Kim, Oh Yoen Kim, Seok Min Kang, Geum Sook Hwang, Min Jeong Shin

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Abstract

Objectives: To test the hypothesis that urinary metabolites characterizing heart failure (HF) are associated with the magnitude of echocardiographic measurements and ultimately the severity of HF. Design/methods: Patients with systolic HF (n = 46) and control subjects (n = 32) participated in this study. Patients with type 2 diabetes mellitus were excluded. Echocardiographic measurements were performed, and selected urinary metabolites were quantified. Results: Urinary levels of acetate (p < 0.05), acetone (p < 0.01), cytosine (p < 0.001), methylmalonate (p < 0.001), and phenylacetylglycine (p < 0.01) were significantly higher, while 1-methylnicotinamide (p < 0.05) were significantly lower in HF patients than in controls. There were significant differences in E/E' (p < 0.05), urinary levels of acetate (p < 0.005), acetoacetate (p < 0.05), acetone (p < 0.05) and ketones (p < 0.01) according to the New York Heart Association (NYHA) classification in HF patients. Multiple linear regression analysis revealed that urinary ketones were found to be independent factors for both left ventricular ejection fraction and E/E' after adjusting for confounders. Conclusion: Our results showed that urinary levels of ketone bodies are associated with the magnitude of echocardiographic parameters.

Original languageEnglish
Pages (from-to)1697-1699
Number of pages3
JournalClinical Biochemistry
Volume45
Issue number18
DOIs
Publication statusPublished - 2012 Dec

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

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    Chung, J. H., Kim, J. S., Kim, O. Y., Kang, S. M., Hwang, G. S., & Shin, M. J. (2012). Urinary ketone is associated with the heart failure severity. Clinical Biochemistry, 45(18), 1697-1699. https://doi.org/10.1016/j.clinbiochem.2012.08.013