US-guided diffuse optical tomography for breast lesions: The reliability of clinical experience

Min Jung Kim, Ji Youn Kim, Jung Hyun Youn, Myung Hyun Kim, Hye Ryoung Koo, Soo Jin Kim, Yu Mee Sohn, Hee Jung Moon, Eun Kyung Kim

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose: To prospectively assess the reliability of US-guided diffuse optical tomography (US-DOT) using interobserver agreement for the diagnosis of breast lesions with individual real-time imaging and to assess the interobserver agreement of conventional sonography (US) combined with US-DOT for differentiation between benignity and malignancy breast lesions. Materials and Methods: An Institutional Review Board approved this study, and all subjects provided written informed consent. 122 breast lesions in 111 patients evaluated with US-guided core biopsy were included. Assessments with US and US-DOT for cases subjected to biopsy were obtained by two radiologists using individual real-time imaging prior to biopsy and were prospectively recorded by each performer. With DOT, the total haemoglobin concentration (THC) for each breast lesion was measured. Histopathological results from US-guided biopsies were used as a reference standard. To assess measurement interobserver agreement, the intraclass correlation coefficient (ICC) and the Bland-Altman plot were used for THC in US-DOT and the kappa values and ROC analysis were used to evaluate the diagnostic performances of the US BI-RADS final assessment in US and combined US and US-DOT. Results: Of 122 US-guided core biopsied lesions, 83 (68.0%) were diagnosed as benign, and 39 (32.0%) as malignant. Excellent correlation was seen in the THC in US-DOT (ICC score 0.796; 95% confidence interval, 0.708-0.857). The interobserver agreement in BI-RADS final assessment with US and US-DOT (almost perfect; κ∈=∈0.8618) was improved compared with that of US (substantial agreement, κ∈=∈0.6574). However, the overall areas under the ROC curve did not show significant differences between US and combined US and US-DOT, 0.8894 and 0.8975, respectively (P∈=∈0.981). Conclusions: The reliability of THC in US-DOT showed excellent correlation in overall real-time performance. Although the inter-observer agreement for BI-RADS final assessment of US was improved by using US-DOT, the performances of radiologists with respect to the characterization of breast masses as benign or malignant were not significantly improved with US-DOT.

Original languageEnglish
Pages (from-to)1353-1363
Number of pages11
JournalEuropean Radiology
Volume21
Issue number7
DOIs
Publication statusPublished - 2011 Jul 1

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Optical Tomography
Breast
Hemoglobins
Biopsy
ROC Curve
Research Ethics Committees
Informed Consent
Area Under Curve
Ultrasonography

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Kim, Min Jung ; Kim, Ji Youn ; Youn, Jung Hyun ; Kim, Myung Hyun ; Koo, Hye Ryoung ; Kim, Soo Jin ; Sohn, Yu Mee ; Moon, Hee Jung ; Kim, Eun Kyung. / US-guided diffuse optical tomography for breast lesions : The reliability of clinical experience. In: European Radiology. 2011 ; Vol. 21, No. 7. pp. 1353-1363.
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title = "US-guided diffuse optical tomography for breast lesions: The reliability of clinical experience",
abstract = "Purpose: To prospectively assess the reliability of US-guided diffuse optical tomography (US-DOT) using interobserver agreement for the diagnosis of breast lesions with individual real-time imaging and to assess the interobserver agreement of conventional sonography (US) combined with US-DOT for differentiation between benignity and malignancy breast lesions. Materials and Methods: An Institutional Review Board approved this study, and all subjects provided written informed consent. 122 breast lesions in 111 patients evaluated with US-guided core biopsy were included. Assessments with US and US-DOT for cases subjected to biopsy were obtained by two radiologists using individual real-time imaging prior to biopsy and were prospectively recorded by each performer. With DOT, the total haemoglobin concentration (THC) for each breast lesion was measured. Histopathological results from US-guided biopsies were used as a reference standard. To assess measurement interobserver agreement, the intraclass correlation coefficient (ICC) and the Bland-Altman plot were used for THC in US-DOT and the kappa values and ROC analysis were used to evaluate the diagnostic performances of the US BI-RADS final assessment in US and combined US and US-DOT. Results: Of 122 US-guided core biopsied lesions, 83 (68.0{\%}) were diagnosed as benign, and 39 (32.0{\%}) as malignant. Excellent correlation was seen in the THC in US-DOT (ICC score 0.796; 95{\%} confidence interval, 0.708-0.857). The interobserver agreement in BI-RADS final assessment with US and US-DOT (almost perfect; κ∈=∈0.8618) was improved compared with that of US (substantial agreement, κ∈=∈0.6574). However, the overall areas under the ROC curve did not show significant differences between US and combined US and US-DOT, 0.8894 and 0.8975, respectively (P∈=∈0.981). Conclusions: The reliability of THC in US-DOT showed excellent correlation in overall real-time performance. Although the inter-observer agreement for BI-RADS final assessment of US was improved by using US-DOT, the performances of radiologists with respect to the characterization of breast masses as benign or malignant were not significantly improved with US-DOT.",
author = "Kim, {Min Jung} and Kim, {Ji Youn} and Youn, {Jung Hyun} and Kim, {Myung Hyun} and Koo, {Hye Ryoung} and Kim, {Soo Jin} and Sohn, {Yu Mee} and Moon, {Hee Jung} and Kim, {Eun Kyung}",
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US-guided diffuse optical tomography for breast lesions : The reliability of clinical experience. / Kim, Min Jung; Kim, Ji Youn; Youn, Jung Hyun; Kim, Myung Hyun; Koo, Hye Ryoung; Kim, Soo Jin; Sohn, Yu Mee; Moon, Hee Jung; Kim, Eun Kyung.

In: European Radiology, Vol. 21, No. 7, 01.07.2011, p. 1353-1363.

Research output: Contribution to journalArticle

TY - JOUR

T1 - US-guided diffuse optical tomography for breast lesions

T2 - The reliability of clinical experience

AU - Kim, Min Jung

AU - Kim, Ji Youn

AU - Youn, Jung Hyun

AU - Kim, Myung Hyun

AU - Koo, Hye Ryoung

AU - Kim, Soo Jin

AU - Sohn, Yu Mee

AU - Moon, Hee Jung

AU - Kim, Eun Kyung

PY - 2011/7/1

Y1 - 2011/7/1

N2 - Purpose: To prospectively assess the reliability of US-guided diffuse optical tomography (US-DOT) using interobserver agreement for the diagnosis of breast lesions with individual real-time imaging and to assess the interobserver agreement of conventional sonography (US) combined with US-DOT for differentiation between benignity and malignancy breast lesions. Materials and Methods: An Institutional Review Board approved this study, and all subjects provided written informed consent. 122 breast lesions in 111 patients evaluated with US-guided core biopsy were included. Assessments with US and US-DOT for cases subjected to biopsy were obtained by two radiologists using individual real-time imaging prior to biopsy and were prospectively recorded by each performer. With DOT, the total haemoglobin concentration (THC) for each breast lesion was measured. Histopathological results from US-guided biopsies were used as a reference standard. To assess measurement interobserver agreement, the intraclass correlation coefficient (ICC) and the Bland-Altman plot were used for THC in US-DOT and the kappa values and ROC analysis were used to evaluate the diagnostic performances of the US BI-RADS final assessment in US and combined US and US-DOT. Results: Of 122 US-guided core biopsied lesions, 83 (68.0%) were diagnosed as benign, and 39 (32.0%) as malignant. Excellent correlation was seen in the THC in US-DOT (ICC score 0.796; 95% confidence interval, 0.708-0.857). The interobserver agreement in BI-RADS final assessment with US and US-DOT (almost perfect; κ∈=∈0.8618) was improved compared with that of US (substantial agreement, κ∈=∈0.6574). However, the overall areas under the ROC curve did not show significant differences between US and combined US and US-DOT, 0.8894 and 0.8975, respectively (P∈=∈0.981). Conclusions: The reliability of THC in US-DOT showed excellent correlation in overall real-time performance. Although the inter-observer agreement for BI-RADS final assessment of US was improved by using US-DOT, the performances of radiologists with respect to the characterization of breast masses as benign or malignant were not significantly improved with US-DOT.

AB - Purpose: To prospectively assess the reliability of US-guided diffuse optical tomography (US-DOT) using interobserver agreement for the diagnosis of breast lesions with individual real-time imaging and to assess the interobserver agreement of conventional sonography (US) combined with US-DOT for differentiation between benignity and malignancy breast lesions. Materials and Methods: An Institutional Review Board approved this study, and all subjects provided written informed consent. 122 breast lesions in 111 patients evaluated with US-guided core biopsy were included. Assessments with US and US-DOT for cases subjected to biopsy were obtained by two radiologists using individual real-time imaging prior to biopsy and were prospectively recorded by each performer. With DOT, the total haemoglobin concentration (THC) for each breast lesion was measured. Histopathological results from US-guided biopsies were used as a reference standard. To assess measurement interobserver agreement, the intraclass correlation coefficient (ICC) and the Bland-Altman plot were used for THC in US-DOT and the kappa values and ROC analysis were used to evaluate the diagnostic performances of the US BI-RADS final assessment in US and combined US and US-DOT. Results: Of 122 US-guided core biopsied lesions, 83 (68.0%) were diagnosed as benign, and 39 (32.0%) as malignant. Excellent correlation was seen in the THC in US-DOT (ICC score 0.796; 95% confidence interval, 0.708-0.857). The interobserver agreement in BI-RADS final assessment with US and US-DOT (almost perfect; κ∈=∈0.8618) was improved compared with that of US (substantial agreement, κ∈=∈0.6574). However, the overall areas under the ROC curve did not show significant differences between US and combined US and US-DOT, 0.8894 and 0.8975, respectively (P∈=∈0.981). Conclusions: The reliability of THC in US-DOT showed excellent correlation in overall real-time performance. Although the inter-observer agreement for BI-RADS final assessment of US was improved by using US-DOT, the performances of radiologists with respect to the characterization of breast masses as benign or malignant were not significantly improved with US-DOT.

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