US-localized diffuse optical tomography in breast cancer: Comparison with pharmacokinetic parameters of DCE-MRI and with pathologic biomarkers

Min Jung Kim, Min Ying Su, Hon J. Yu, Jeon Hor Chen, Eun Kyung Kim, Hee Jung Moon, Ji Soo Choi

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6 Citations (Scopus)


Background: To correlate parameters of Ultrasonography-guided Diffuse optical tomography (US-DOT) with pharmacokinetic features of Dynamic contrast-enhanced (DCE)-MRI and pathologic markers of breast cancer. Methods: Our institutional review board approved this retrospective study and waived the requirement for informed consent. Thirty seven breast cancer patients received US-DOT and DCE-MRI with less than two weeks in between imaging sessions. The maximal total hemoglobin concentration (THC) measured by US-DOT was correlated with DCE-MRI pharmacokinetic parameters, which included K trans , k ep and signal enhancement ratio (SER). These imaging parameters were also correlated with the pathologic biomarkers of breast cancer. Results: The parameters THC and SER showed marginal positive correlation (r = 0.303, p = 0.058). Tumors with high histological grade, negative ER, and higher Ki-67 expression ≥20 % showed statistically higher THC values compared to their counterparts (p = 0.019, 0.041, and 0.023 respectively). Triple-negative (TN) breast cancers showed statistically higher K trans values than non-TN cancers (p = 0.048). Conclusion: THC obtained from US-DOT and K trans obtained from DCE-MRI were associated with biomarkers indicative of a higher aggressiveness in breast cancer. Although US-DOT and DCE-MRI both measured the vascular properties of breast cancer, parameters from the two imaging modalities showed a weak association presumably due to their different contrast mechanisms and depth sensitivities.

Original languageEnglish
Article number50
JournalBMC cancer
Issue number1
Publication statusPublished - 2016 Feb 1

Bibliographical note

Funding Information:
This study was supported by a faculty research grant of Yonsei University College of Medicine for 2012 (6-2012-0087). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Publisher Copyright:
© 2016 Kim et al.

All Science Journal Classification (ASJC) codes

  • Genetics
  • Oncology
  • Cancer Research


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