In its late stage, Alzheimer's disease results in progressive muscle weakness in the arms and legs. The aim of this study was to determine whether mice expressing the skeletal muscle-specific mutant PS2 gene (a model of Alzheimer's disease) are a useful experimental system to study the protective effect of exercise on Aβ-42 reduction, improvement of behavioural function and changes in metabolic parameters. With this aim in mind, the transgenic mice were subjected to treadmill exercise for 3 months. The results showed that in transgenic mice, but not in normal mice, treadmill exercise resulted in a reduction of Aβ-42 deposits and an improvement in behavioural function, thereby restoring normal concentrations of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride. Thus, exercise may represent a practical therapeutic strategy for use with human patients with Alzheimer's disease.
Bibliographical noteFunding Information:
We thank Sun M. Choi and Mi K. Jang, animal technicians, for directing the animal facility at the Division of Laboratory Animal Resources. This research was supported by grants to Yong K. Kim from the Korean Ministry of Health and Welfare (01-PJ1-963-20500-0129) and the Korea FDA.
All Science Journal Classification (ASJC) codes
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation