Use of strain ratio in evaluating superficial soft tissue tumors on ultrasonic elastography

Young Han Lee, Ho Taek Song, Jinsuck Suh

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Object: The aim of this study was to describe the strain ratio in histopathologically confirmed superficial soft tissue tumors using ultrasonic elastography (USE). Methods: From March to August 2012, 94 soft tissue tumors in 79 consecutive patients (age range 19-70 years) were examined using USE for palpable masses. Among them, 39 lesions in 36 patients were histopathologically confirmed. Thirty-four lesions in 31 patients with lipoma, ganglion, epidermal inclusion cyst, and pilomatricoma were included: 34 histopathologically confirmed mature lipomas (n = 19), ganglia (n = 6), epidermal inclusion cysts (n = 5), and pilomatricomas (n = 4). Ultrasonographic features of margins, echogenicity, walls, ultrasonic transmission, and vascular flow via Doppler ultrasonography were evaluated. The strain ratios were calculated from the USE strain measured within the lesion and in adjacent tissue. Intraclass correlation (ICC) with Cohen's kappa was used to determine intraobserver agreement, and the strain ratios of the three groups were compared using Mann-Whitney U tests. All statistical analyses were performed using R package statistical software, and p values <0.05 were considered to be statistically significant. Results: On USE, repeated measurements of the strain ratios showed excellent intraobserver agreement [ICC value = 0.952 (CI 0.905-0.977), p < 0.05]. The strain ratios of lipomas (median ± standard error 0.83 ± 0.18) were statistically different (p < 0.05) from those of ganglia, epidermal inclusion cysts, and pilomatricomas. The strain ratios of ganglia (2.78 ± 0.48) were also statistically different (p < 0.05) from those of epidermal inclusion cysts and pilomatricomas. The strain ratios of epidermal inclusion cysts (0.17 ± 0.21) were not statistically different (p > 0.05) from that of pilomatricomas (0.13 ± 0.02). Conclusion: Strain ratios determined by USE help to differentiate lipomas and ganglia from other superficial soft tissue tumors. Our results suggest that USE could be used in addition to traditional ultrasound techniques to obtain diagnostic clues in the evaluation of superficial soft tissue tumors.

Original languageEnglish
Pages (from-to)319-323
Number of pages5
JournalJournal of Medical Ultrasonics
Volume41
Issue number3
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Elasticity Imaging Techniques
Ultrasonics
Pilomatrixoma
Lipoma
Ganglia
Epidermal Cyst
Neoplasms
Doppler Ultrasonography
Nonparametric Statistics
Blood Vessels
Software

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

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title = "Use of strain ratio in evaluating superficial soft tissue tumors on ultrasonic elastography",
abstract = "Object: The aim of this study was to describe the strain ratio in histopathologically confirmed superficial soft tissue tumors using ultrasonic elastography (USE). Methods: From March to August 2012, 94 soft tissue tumors in 79 consecutive patients (age range 19-70 years) were examined using USE for palpable masses. Among them, 39 lesions in 36 patients were histopathologically confirmed. Thirty-four lesions in 31 patients with lipoma, ganglion, epidermal inclusion cyst, and pilomatricoma were included: 34 histopathologically confirmed mature lipomas (n = 19), ganglia (n = 6), epidermal inclusion cysts (n = 5), and pilomatricomas (n = 4). Ultrasonographic features of margins, echogenicity, walls, ultrasonic transmission, and vascular flow via Doppler ultrasonography were evaluated. The strain ratios were calculated from the USE strain measured within the lesion and in adjacent tissue. Intraclass correlation (ICC) with Cohen's kappa was used to determine intraobserver agreement, and the strain ratios of the three groups were compared using Mann-Whitney U tests. All statistical analyses were performed using R package statistical software, and p values <0.05 were considered to be statistically significant. Results: On USE, repeated measurements of the strain ratios showed excellent intraobserver agreement [ICC value = 0.952 (CI 0.905-0.977), p < 0.05]. The strain ratios of lipomas (median ± standard error 0.83 ± 0.18) were statistically different (p < 0.05) from those of ganglia, epidermal inclusion cysts, and pilomatricomas. The strain ratios of ganglia (2.78 ± 0.48) were also statistically different (p < 0.05) from those of epidermal inclusion cysts and pilomatricomas. The strain ratios of epidermal inclusion cysts (0.17 ± 0.21) were not statistically different (p > 0.05) from that of pilomatricomas (0.13 ± 0.02). Conclusion: Strain ratios determined by USE help to differentiate lipomas and ganglia from other superficial soft tissue tumors. Our results suggest that USE could be used in addition to traditional ultrasound techniques to obtain diagnostic clues in the evaluation of superficial soft tissue tumors.",
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Use of strain ratio in evaluating superficial soft tissue tumors on ultrasonic elastography. / Lee, Young Han; Song, Ho Taek; Suh, Jinsuck.

In: Journal of Medical Ultrasonics, Vol. 41, No. 3, 01.01.2014, p. 319-323.

Research output: Contribution to journalArticle

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N2 - Object: The aim of this study was to describe the strain ratio in histopathologically confirmed superficial soft tissue tumors using ultrasonic elastography (USE). Methods: From March to August 2012, 94 soft tissue tumors in 79 consecutive patients (age range 19-70 years) were examined using USE for palpable masses. Among them, 39 lesions in 36 patients were histopathologically confirmed. Thirty-four lesions in 31 patients with lipoma, ganglion, epidermal inclusion cyst, and pilomatricoma were included: 34 histopathologically confirmed mature lipomas (n = 19), ganglia (n = 6), epidermal inclusion cysts (n = 5), and pilomatricomas (n = 4). Ultrasonographic features of margins, echogenicity, walls, ultrasonic transmission, and vascular flow via Doppler ultrasonography were evaluated. The strain ratios were calculated from the USE strain measured within the lesion and in adjacent tissue. Intraclass correlation (ICC) with Cohen's kappa was used to determine intraobserver agreement, and the strain ratios of the three groups were compared using Mann-Whitney U tests. All statistical analyses were performed using R package statistical software, and p values <0.05 were considered to be statistically significant. Results: On USE, repeated measurements of the strain ratios showed excellent intraobserver agreement [ICC value = 0.952 (CI 0.905-0.977), p < 0.05]. The strain ratios of lipomas (median ± standard error 0.83 ± 0.18) were statistically different (p < 0.05) from those of ganglia, epidermal inclusion cysts, and pilomatricomas. The strain ratios of ganglia (2.78 ± 0.48) were also statistically different (p < 0.05) from those of epidermal inclusion cysts and pilomatricomas. The strain ratios of epidermal inclusion cysts (0.17 ± 0.21) were not statistically different (p > 0.05) from that of pilomatricomas (0.13 ± 0.02). Conclusion: Strain ratios determined by USE help to differentiate lipomas and ganglia from other superficial soft tissue tumors. Our results suggest that USE could be used in addition to traditional ultrasound techniques to obtain diagnostic clues in the evaluation of superficial soft tissue tumors.

AB - Object: The aim of this study was to describe the strain ratio in histopathologically confirmed superficial soft tissue tumors using ultrasonic elastography (USE). Methods: From March to August 2012, 94 soft tissue tumors in 79 consecutive patients (age range 19-70 years) were examined using USE for palpable masses. Among them, 39 lesions in 36 patients were histopathologically confirmed. Thirty-four lesions in 31 patients with lipoma, ganglion, epidermal inclusion cyst, and pilomatricoma were included: 34 histopathologically confirmed mature lipomas (n = 19), ganglia (n = 6), epidermal inclusion cysts (n = 5), and pilomatricomas (n = 4). Ultrasonographic features of margins, echogenicity, walls, ultrasonic transmission, and vascular flow via Doppler ultrasonography were evaluated. The strain ratios were calculated from the USE strain measured within the lesion and in adjacent tissue. Intraclass correlation (ICC) with Cohen's kappa was used to determine intraobserver agreement, and the strain ratios of the three groups were compared using Mann-Whitney U tests. All statistical analyses were performed using R package statistical software, and p values <0.05 were considered to be statistically significant. Results: On USE, repeated measurements of the strain ratios showed excellent intraobserver agreement [ICC value = 0.952 (CI 0.905-0.977), p < 0.05]. The strain ratios of lipomas (median ± standard error 0.83 ± 0.18) were statistically different (p < 0.05) from those of ganglia, epidermal inclusion cysts, and pilomatricomas. The strain ratios of ganglia (2.78 ± 0.48) were also statistically different (p < 0.05) from those of epidermal inclusion cysts and pilomatricomas. The strain ratios of epidermal inclusion cysts (0.17 ± 0.21) were not statistically different (p > 0.05) from that of pilomatricomas (0.13 ± 0.02). Conclusion: Strain ratios determined by USE help to differentiate lipomas and ganglia from other superficial soft tissue tumors. Our results suggest that USE could be used in addition to traditional ultrasound techniques to obtain diagnostic clues in the evaluation of superficial soft tissue tumors.

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