Use of the delta neutrophil Index as a prognostic factor of mortality in patients with spontaneous bacterial peritonitis

Implications of a simple and useful marker

Tae Seop Lim, Beom Kyung Kim, Jong Wook Lee, Young Ki Lee, Sooyun Chang, Seungup Kim, doyoung kim, SangHoon Ahn, KwangHyub Han, Chae Yoon Chon, Junyong Park

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Spontaneous bacterial peritonitis (SBP) is a common and life-threatening infection in patients with advanced cirrhosis. The prognostic value of a novel marker, the delta neutrophil index (DNI), was investigated relative to mortality in patients with SBP. Materials & Methods: Seventy-five patients with SBP were studied from April 2010 to May 2012. DNI at initial diagnosis of SBP was determined and compared with 30-day mortality rates. Results: Of the patients, 87.7% were men, and the median age of all patients was 59.0 yrs. The area under the receiveroperating characteristic (ROC) curve of DNI for 30-day mortality was 0.701 (95% confidence interval [CI], 0.553-0.849; p = 0.009), which was higher than that of C-reactive protein (0.640, 95% CI, 0.494-0.786; p = 0.076) or the model for endstage liver disease score (0.592, 95% CI, 0.436-0.748; p = 0.235). From the ROC curve, with the sum of sensitivity and specificity, the cutoff value of DNI was determined to be 5.7%. In the high-DNI group (DNI ≥5.7%), septic shock and 30-day mortality were more prevalent compared with the low-DNI group (84.2% vs. 48.2%, p = 0.007; 57.9% vs. 14.3%, p<0.001, respectively). Patients with an elevated DNI had a higher risk of 30-day mortality compared with those with a low DNI (4.225, 95% CI, 1.631-10.949; p = 0.003). Conclusion: A higher DNI at the time of SBP diagnosis is an independent predictor of 30-day mortality in patients with SBP.

Original languageEnglish
Article numbere86884
JournalPLoS One
Volume9
Issue number1
DOIs
Publication statusPublished - 2014 Jan 23

Fingerprint

peritonitis
Peritonitis
neutrophils
Neutrophils
Mortality
Liver
C-Reactive Protein
confidence interval
Confidence Intervals
septic shock
C-reactive protein
liver diseases
Septic Shock
Liver Diseases
Fibrosis
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

@article{0bf732af293e4bf6add33285719cc6c8,
title = "Use of the delta neutrophil Index as a prognostic factor of mortality in patients with spontaneous bacterial peritonitis: Implications of a simple and useful marker",
abstract = "Background: Spontaneous bacterial peritonitis (SBP) is a common and life-threatening infection in patients with advanced cirrhosis. The prognostic value of a novel marker, the delta neutrophil index (DNI), was investigated relative to mortality in patients with SBP. Materials & Methods: Seventy-five patients with SBP were studied from April 2010 to May 2012. DNI at initial diagnosis of SBP was determined and compared with 30-day mortality rates. Results: Of the patients, 87.7{\%} were men, and the median age of all patients was 59.0 yrs. The area under the receiveroperating characteristic (ROC) curve of DNI for 30-day mortality was 0.701 (95{\%} confidence interval [CI], 0.553-0.849; p = 0.009), which was higher than that of C-reactive protein (0.640, 95{\%} CI, 0.494-0.786; p = 0.076) or the model for endstage liver disease score (0.592, 95{\%} CI, 0.436-0.748; p = 0.235). From the ROC curve, with the sum of sensitivity and specificity, the cutoff value of DNI was determined to be 5.7{\%}. In the high-DNI group (DNI ≥5.7{\%}), septic shock and 30-day mortality were more prevalent compared with the low-DNI group (84.2{\%} vs. 48.2{\%}, p = 0.007; 57.9{\%} vs. 14.3{\%}, p<0.001, respectively). Patients with an elevated DNI had a higher risk of 30-day mortality compared with those with a low DNI (4.225, 95{\%} CI, 1.631-10.949; p = 0.003). Conclusion: A higher DNI at the time of SBP diagnosis is an independent predictor of 30-day mortality in patients with SBP.",
author = "Lim, {Tae Seop} and Kim, {Beom Kyung} and Lee, {Jong Wook} and Lee, {Young Ki} and Sooyun Chang and Seungup Kim and doyoung kim and SangHoon Ahn and KwangHyub Han and Chon, {Chae Yoon} and Junyong Park",
year = "2014",
month = "1",
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doi = "10.1371/journal.pone.0086884",
language = "English",
volume = "9",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
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}

Use of the delta neutrophil Index as a prognostic factor of mortality in patients with spontaneous bacterial peritonitis : Implications of a simple and useful marker. / Lim, Tae Seop; Kim, Beom Kyung; Lee, Jong Wook; Lee, Young Ki; Chang, Sooyun; Kim, Seungup; kim, doyoung; Ahn, SangHoon; Han, KwangHyub; Chon, Chae Yoon; Park, Junyong.

In: PLoS One, Vol. 9, No. 1, e86884, 23.01.2014.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Use of the delta neutrophil Index as a prognostic factor of mortality in patients with spontaneous bacterial peritonitis

T2 - Implications of a simple and useful marker

AU - Lim, Tae Seop

AU - Kim, Beom Kyung

AU - Lee, Jong Wook

AU - Lee, Young Ki

AU - Chang, Sooyun

AU - Kim, Seungup

AU - kim, doyoung

AU - Ahn, SangHoon

AU - Han, KwangHyub

AU - Chon, Chae Yoon

AU - Park, Junyong

PY - 2014/1/23

Y1 - 2014/1/23

N2 - Background: Spontaneous bacterial peritonitis (SBP) is a common and life-threatening infection in patients with advanced cirrhosis. The prognostic value of a novel marker, the delta neutrophil index (DNI), was investigated relative to mortality in patients with SBP. Materials & Methods: Seventy-five patients with SBP were studied from April 2010 to May 2012. DNI at initial diagnosis of SBP was determined and compared with 30-day mortality rates. Results: Of the patients, 87.7% were men, and the median age of all patients was 59.0 yrs. The area under the receiveroperating characteristic (ROC) curve of DNI for 30-day mortality was 0.701 (95% confidence interval [CI], 0.553-0.849; p = 0.009), which was higher than that of C-reactive protein (0.640, 95% CI, 0.494-0.786; p = 0.076) or the model for endstage liver disease score (0.592, 95% CI, 0.436-0.748; p = 0.235). From the ROC curve, with the sum of sensitivity and specificity, the cutoff value of DNI was determined to be 5.7%. In the high-DNI group (DNI ≥5.7%), septic shock and 30-day mortality were more prevalent compared with the low-DNI group (84.2% vs. 48.2%, p = 0.007; 57.9% vs. 14.3%, p<0.001, respectively). Patients with an elevated DNI had a higher risk of 30-day mortality compared with those with a low DNI (4.225, 95% CI, 1.631-10.949; p = 0.003). Conclusion: A higher DNI at the time of SBP diagnosis is an independent predictor of 30-day mortality in patients with SBP.

AB - Background: Spontaneous bacterial peritonitis (SBP) is a common and life-threatening infection in patients with advanced cirrhosis. The prognostic value of a novel marker, the delta neutrophil index (DNI), was investigated relative to mortality in patients with SBP. Materials & Methods: Seventy-five patients with SBP were studied from April 2010 to May 2012. DNI at initial diagnosis of SBP was determined and compared with 30-day mortality rates. Results: Of the patients, 87.7% were men, and the median age of all patients was 59.0 yrs. The area under the receiveroperating characteristic (ROC) curve of DNI for 30-day mortality was 0.701 (95% confidence interval [CI], 0.553-0.849; p = 0.009), which was higher than that of C-reactive protein (0.640, 95% CI, 0.494-0.786; p = 0.076) or the model for endstage liver disease score (0.592, 95% CI, 0.436-0.748; p = 0.235). From the ROC curve, with the sum of sensitivity and specificity, the cutoff value of DNI was determined to be 5.7%. In the high-DNI group (DNI ≥5.7%), septic shock and 30-day mortality were more prevalent compared with the low-DNI group (84.2% vs. 48.2%, p = 0.007; 57.9% vs. 14.3%, p<0.001, respectively). Patients with an elevated DNI had a higher risk of 30-day mortality compared with those with a low DNI (4.225, 95% CI, 1.631-10.949; p = 0.003). Conclusion: A higher DNI at the time of SBP diagnosis is an independent predictor of 30-day mortality in patients with SBP.

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U2 - 10.1371/journal.pone.0086884

DO - 10.1371/journal.pone.0086884

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