Usefulness of diffusion tensor tractography in pediatric epilepsy surgery

Mi Jung Lee, Heung Dong Kim, Joon Soo Lee, Dong Seok Kim, Seung Koo Lee

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Purpose: This study was conducted to assess the clinical relevance of diffusion tensor tractography (DTT) in pre- and post-operative evaluations of childhood epilepsy surgery. Materials and Methods: Seventy-two patients who received epilepsy surgery between March 2004 and July 2008 were retrospectively analyzed (M: F=40: 32, ages of 3 months to 24 years, mean age=8.9 years). DTT was performed using a 3.0 T scanner and single-shot spin-echo echo-planar imaging with 32-different diffusion gradient directions. We reviewed the data focusing on the type of surgery, final pathological diagnosis, and how the DTT data were clinically used. Results: The most common form of childhood epilepsy surgery was complete resection of an epileptogenic lesion (n=52, 72.2%). The reported etiologies included cortical dysplasia (n=32, 44.4%), hippocampal sclerosis (n=9, 12.5%), brain tumors (n=7, 9.7%), and non-pathologic lesions (n=4, 5.6%) in the final diagnoses. Twenty-one dysplastic cortexes and four brain tumors involved an approximal relationship with the corticospinal tract (n=18), optic radiation (n=2), and arcuate fasciculus (n=5). Additionally, although DTT demonstrated white matter tracts clearly, DTT in the hippocampal sclerosis did not provide any additional information. In cases of callosotomy (n=18, 25%), post-operative DTT was utilized for the evaluation of complete resection in all patients. DTT information was not used in functional hemispherectomy (n=2, 2.8%). Conclusion: Preoperatively, DTT was a useful technique in cases of cortical dysplasia and brain tumors, and in cases with callosotomy, postoperatively. DTT should be included among the routine procedures performed in management of epilepsy.

Original languageEnglish
Pages (from-to)21-27
Number of pages7
JournalYonsei medical journal
Volume54
Issue number1
DOIs
Publication statusPublished - 2013 Jan

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Diffusion Tensor Imaging
Epilepsy
Pediatrics
Brain Neoplasms
Malformations of Cortical Development
Sclerosis
Hemispherectomy
Echo-Planar Imaging
Pyramidal Tracts
Radiation

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Lee, Mi Jung ; Kim, Heung Dong ; Lee, Joon Soo ; Kim, Dong Seok ; Lee, Seung Koo. / Usefulness of diffusion tensor tractography in pediatric epilepsy surgery. In: Yonsei medical journal. 2013 ; Vol. 54, No. 1. pp. 21-27.
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abstract = "Purpose: This study was conducted to assess the clinical relevance of diffusion tensor tractography (DTT) in pre- and post-operative evaluations of childhood epilepsy surgery. Materials and Methods: Seventy-two patients who received epilepsy surgery between March 2004 and July 2008 were retrospectively analyzed (M: F=40: 32, ages of 3 months to 24 years, mean age=8.9 years). DTT was performed using a 3.0 T scanner and single-shot spin-echo echo-planar imaging with 32-different diffusion gradient directions. We reviewed the data focusing on the type of surgery, final pathological diagnosis, and how the DTT data were clinically used. Results: The most common form of childhood epilepsy surgery was complete resection of an epileptogenic lesion (n=52, 72.2{\%}). The reported etiologies included cortical dysplasia (n=32, 44.4{\%}), hippocampal sclerosis (n=9, 12.5{\%}), brain tumors (n=7, 9.7{\%}), and non-pathologic lesions (n=4, 5.6{\%}) in the final diagnoses. Twenty-one dysplastic cortexes and four brain tumors involved an approximal relationship with the corticospinal tract (n=18), optic radiation (n=2), and arcuate fasciculus (n=5). Additionally, although DTT demonstrated white matter tracts clearly, DTT in the hippocampal sclerosis did not provide any additional information. In cases of callosotomy (n=18, 25{\%}), post-operative DTT was utilized for the evaluation of complete resection in all patients. DTT information was not used in functional hemispherectomy (n=2, 2.8{\%}). Conclusion: Preoperatively, DTT was a useful technique in cases of cortical dysplasia and brain tumors, and in cases with callosotomy, postoperatively. DTT should be included among the routine procedures performed in management of epilepsy.",
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Usefulness of diffusion tensor tractography in pediatric epilepsy surgery. / Lee, Mi Jung; Kim, Heung Dong; Lee, Joon Soo; Kim, Dong Seok; Lee, Seung Koo.

In: Yonsei medical journal, Vol. 54, No. 1, 01.2013, p. 21-27.

Research output: Contribution to journalReview article

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N2 - Purpose: This study was conducted to assess the clinical relevance of diffusion tensor tractography (DTT) in pre- and post-operative evaluations of childhood epilepsy surgery. Materials and Methods: Seventy-two patients who received epilepsy surgery between March 2004 and July 2008 were retrospectively analyzed (M: F=40: 32, ages of 3 months to 24 years, mean age=8.9 years). DTT was performed using a 3.0 T scanner and single-shot spin-echo echo-planar imaging with 32-different diffusion gradient directions. We reviewed the data focusing on the type of surgery, final pathological diagnosis, and how the DTT data were clinically used. Results: The most common form of childhood epilepsy surgery was complete resection of an epileptogenic lesion (n=52, 72.2%). The reported etiologies included cortical dysplasia (n=32, 44.4%), hippocampal sclerosis (n=9, 12.5%), brain tumors (n=7, 9.7%), and non-pathologic lesions (n=4, 5.6%) in the final diagnoses. Twenty-one dysplastic cortexes and four brain tumors involved an approximal relationship with the corticospinal tract (n=18), optic radiation (n=2), and arcuate fasciculus (n=5). Additionally, although DTT demonstrated white matter tracts clearly, DTT in the hippocampal sclerosis did not provide any additional information. In cases of callosotomy (n=18, 25%), post-operative DTT was utilized for the evaluation of complete resection in all patients. DTT information was not used in functional hemispherectomy (n=2, 2.8%). Conclusion: Preoperatively, DTT was a useful technique in cases of cortical dysplasia and brain tumors, and in cases with callosotomy, postoperatively. DTT should be included among the routine procedures performed in management of epilepsy.

AB - Purpose: This study was conducted to assess the clinical relevance of diffusion tensor tractography (DTT) in pre- and post-operative evaluations of childhood epilepsy surgery. Materials and Methods: Seventy-two patients who received epilepsy surgery between March 2004 and July 2008 were retrospectively analyzed (M: F=40: 32, ages of 3 months to 24 years, mean age=8.9 years). DTT was performed using a 3.0 T scanner and single-shot spin-echo echo-planar imaging with 32-different diffusion gradient directions. We reviewed the data focusing on the type of surgery, final pathological diagnosis, and how the DTT data were clinically used. Results: The most common form of childhood epilepsy surgery was complete resection of an epileptogenic lesion (n=52, 72.2%). The reported etiologies included cortical dysplasia (n=32, 44.4%), hippocampal sclerosis (n=9, 12.5%), brain tumors (n=7, 9.7%), and non-pathologic lesions (n=4, 5.6%) in the final diagnoses. Twenty-one dysplastic cortexes and four brain tumors involved an approximal relationship with the corticospinal tract (n=18), optic radiation (n=2), and arcuate fasciculus (n=5). Additionally, although DTT demonstrated white matter tracts clearly, DTT in the hippocampal sclerosis did not provide any additional information. In cases of callosotomy (n=18, 25%), post-operative DTT was utilized for the evaluation of complete resection in all patients. DTT information was not used in functional hemispherectomy (n=2, 2.8%). Conclusion: Preoperatively, DTT was a useful technique in cases of cortical dysplasia and brain tumors, and in cases with callosotomy, postoperatively. DTT should be included among the routine procedures performed in management of epilepsy.

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