Usefulness of Follow-Up Low-Density Lipoprotein Cholesterol Level as an Independent Predictor of Changes of Coronary Atherosclerotic Plaque Size as Determined by Intravascular Ultrasound Analysis After Statin (Atorvastatin or Simvastatin) Therapy

Myeong Ki Hong, Cheol Whan Lee, Young Hak Kim, Duk Woo Park, Se Whan Lee, Chang Bum Park, Jae Sik Jang, Ki Hoon Han, Sang Sig Cheong, Jae Joong Kim, Seong Wook Park, Seung Jung Park

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Abstract

Using serial intravascular ultrasound (IVUS), we identified independent predictors of changes in coronary plaque size in relation to serum lipid levels. One hundred three patients with nonstenotic coronary plaques underwent baseline and 12-month follow-up IVUS studies; 54 patients (52%) were treated with statins. Standard IVUS analyses were performed. Baseline IVUS study showed no statistical differences in mean external elastic membrane, lumen, and plaque/media (P&M) area between statin-treated and nonstatin-treated patients. Although there was an increase in mean P&M cross-sectional area in nonstatin-treated patients, mean P&M cross-sectional area decreased in statin-treated patients (0.11 ± 0.24 vs -0.20 ± 0.30 mm2, p <0.001). There was a positive relation between changes in mean P&M area and follow-up low-density lipoprotein (LDL) cholesterol level (r = 0.430, p <0.001), follow-up total cholesterol level (r = 0.365, p <0.001), changes in LDL cholesterol level (r = 0.312, p = 0.002), and changes in total cholesterol level (r = 0.252, p = 0.012). In multivariate linear regression analysis, the only independent predictor of changes in mean P&M area was follow-up LDL cholesterol level (r = 0.469, p <0.001, 95% confidence interval 0.003 to 0.006). The cut-off value of follow-up LDL cholesterol for no change or a decrease in mean P&M area was <100 mg/dl at regression analysis. In conclusion, the present 12-month follow-up IVUS study showed that follow-up LDL cholesterol level was the only independent predictor of changes in coronary plaque size. When patients achieved a follow-up LDL cholesterol level <100 mg/dl, regression or no progression of coronary plaque was expected. Aggressive lipid-lowering treatments with statins to decrease the follow-up LDL cholesterol level to <100 mg/dl are recommended.

Original languageEnglish
Pages (from-to)866-870
Number of pages5
JournalAmerican Journal of Cardiology
Volume98
Issue number7
DOIs
Publication statusPublished - 2006 Oct 1

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Simvastatin
Atherosclerotic Plaques
LDL Cholesterol
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Therapeutics
Cholesterol
Regression Analysis
Lipids
Atorvastatin Calcium
Linear Models
Confidence Intervals
Membranes
Serum

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Hong, Myeong Ki ; Lee, Cheol Whan ; Kim, Young Hak ; Park, Duk Woo ; Lee, Se Whan ; Park, Chang Bum ; Jang, Jae Sik ; Han, Ki Hoon ; Cheong, Sang Sig ; Kim, Jae Joong ; Park, Seong Wook ; Park, Seung Jung. / Usefulness of Follow-Up Low-Density Lipoprotein Cholesterol Level as an Independent Predictor of Changes of Coronary Atherosclerotic Plaque Size as Determined by Intravascular Ultrasound Analysis After Statin (Atorvastatin or Simvastatin) Therapy. In: American Journal of Cardiology. 2006 ; Vol. 98, No. 7. pp. 866-870.
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abstract = "Using serial intravascular ultrasound (IVUS), we identified independent predictors of changes in coronary plaque size in relation to serum lipid levels. One hundred three patients with nonstenotic coronary plaques underwent baseline and 12-month follow-up IVUS studies; 54 patients (52{\%}) were treated with statins. Standard IVUS analyses were performed. Baseline IVUS study showed no statistical differences in mean external elastic membrane, lumen, and plaque/media (P&M) area between statin-treated and nonstatin-treated patients. Although there was an increase in mean P&M cross-sectional area in nonstatin-treated patients, mean P&M cross-sectional area decreased in statin-treated patients (0.11 ± 0.24 vs -0.20 ± 0.30 mm2, p <0.001). There was a positive relation between changes in mean P&M area and follow-up low-density lipoprotein (LDL) cholesterol level (r = 0.430, p <0.001), follow-up total cholesterol level (r = 0.365, p <0.001), changes in LDL cholesterol level (r = 0.312, p = 0.002), and changes in total cholesterol level (r = 0.252, p = 0.012). In multivariate linear regression analysis, the only independent predictor of changes in mean P&M area was follow-up LDL cholesterol level (r = 0.469, p <0.001, 95{\%} confidence interval 0.003 to 0.006). The cut-off value of follow-up LDL cholesterol for no change or a decrease in mean P&M area was <100 mg/dl at regression analysis. In conclusion, the present 12-month follow-up IVUS study showed that follow-up LDL cholesterol level was the only independent predictor of changes in coronary plaque size. When patients achieved a follow-up LDL cholesterol level <100 mg/dl, regression or no progression of coronary plaque was expected. Aggressive lipid-lowering treatments with statins to decrease the follow-up LDL cholesterol level to <100 mg/dl are recommended.",
author = "Hong, {Myeong Ki} and Lee, {Cheol Whan} and Kim, {Young Hak} and Park, {Duk Woo} and Lee, {Se Whan} and Park, {Chang Bum} and Jang, {Jae Sik} and Han, {Ki Hoon} and Cheong, {Sang Sig} and Kim, {Jae Joong} and Park, {Seong Wook} and Park, {Seung Jung}",
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Usefulness of Follow-Up Low-Density Lipoprotein Cholesterol Level as an Independent Predictor of Changes of Coronary Atherosclerotic Plaque Size as Determined by Intravascular Ultrasound Analysis After Statin (Atorvastatin or Simvastatin) Therapy. / Hong, Myeong Ki; Lee, Cheol Whan; Kim, Young Hak; Park, Duk Woo; Lee, Se Whan; Park, Chang Bum; Jang, Jae Sik; Han, Ki Hoon; Cheong, Sang Sig; Kim, Jae Joong; Park, Seong Wook; Park, Seung Jung.

In: American Journal of Cardiology, Vol. 98, No. 7, 01.10.2006, p. 866-870.

Research output: Contribution to journalArticle

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AU - Hong, Myeong Ki

AU - Lee, Cheol Whan

AU - Kim, Young Hak

AU - Park, Duk Woo

AU - Lee, Se Whan

AU - Park, Chang Bum

AU - Jang, Jae Sik

AU - Han, Ki Hoon

AU - Cheong, Sang Sig

AU - Kim, Jae Joong

AU - Park, Seong Wook

AU - Park, Seung Jung

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