Usefulness of intravascular ultrasound to predict outcomes in short-length lesions treated with drug-eluting stents

Young Won Yoon, Sanghoon Shin, Byeong Keuk Kim, Jung Sun Kim, Dong Ho Shin, Young Guk Ko, Donghoon Choi, Dong Woon Jeon, Hyuckmoon Kwon, Yangsoo Jang, Myeong Ki Hong

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16 Citations (Scopus)


Intravascular ultrasound (IVUS) offers tomographic images of the coronary artery, helping physicians to refine drug-eluting stent (DES) implantation in angiographically complex lesions. However, controversy exists regarding whether the routine use of IVUS in short-length lesions leads to improved clinical outcomes after DES implantation. Therefore, we evaluated the usefulness of IVUS in predicting major adverse cardiac events (MACE), including cardiovascular death, myocardial infarction, or target vessel revascularization, at 1 year after DES implantation in short-length lesions. The present study was a subanalysis of the REal Safety and Efficacy of a 3-month dual antiplatelet Therapy following Endeavor zotarolimus-eluting stent implantation (RESET) study with different clinical outcome parameters. The study population consisted of 662 patients with IVUS guidance and 912 patients with angiography guidance who underwent DES implantation (stent length ≤24 mm). In the IVUS-guided group, adjuvant postdilation was more frequently performed (43.0% vs 34.6%, p <0.001), and the postintervention minimal lumen diameters were greater (2.88 ± 0.44 mm vs 2.72 ± 0.43 mm, p <0.001). MACE occurred in 15 IVUS-guided (2.3%) and 19 angiographically guided (2.1%) patients (p = 0.872). In a subset of patients with diabetes mellitus (n = 292), the MACE rate was 3.4% (n = 4) and 1.7% (n = 3) in the IVUS- and angiographically guided patients, respectively (p = 0.384). The MACE rate in the IVUS- and angiographically guided patients with acute coronary syndrome (n = 601) was 1.1% (n = 3) and 2.7% (n = 9), respectively (p = 0.194). The clinical benefits of IVUS-guided DES implantation compared with angiographically guided DES implantation in short-length lesions could not be confirmed even in patients with clinically high-risk presentations (acute coronary syndrome and diabetes mellitus). In conclusion, routine IVUS guidance does not provide clinical benefits when performing short-length DES implantation.

Original languageEnglish
Pages (from-to)642-646
Number of pages5
JournalAmerican Journal of Cardiology
Issue number5
Publication statusPublished - 2013 Sep 1

Bibliographical note

Funding Information:
This study was supported by the Cardiovascular Research Center (Seoul, South Korea) , grants A085012 and A102064 from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare & Family Affairs (Seoul, South Korea) , and grant A085136 from the Korea Health 21 R&D Project, Ministry of Health & Welfare (Seoul, South Korea) .

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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