Usefulness of liquid ketogenic milk for intractable childhood epilepsy

Yun Jin Lee, Hoon Chul Kang, Dong Wook Kim, Joon Soo Lee, Baik Lin Eun, So Hee Eun, Su Jeong You, Ji Eun Song, Eun Joo Lee, Heung Dong Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background & aims: To evaluate the usefulness of a liquid ketogenic milk in the treatment of intractable childhood epilepsy. Methods: We used liquid ketogenic milk, which is comprised of mainly olive oil and soybeans, and has a lipid to non-lipid ratio of 4:1. Prospective study evaluated outcomes in 28 children with intractable epilepsy who were supplemented with liquid ketogenic milk for at least three months during conventional ketogenic diet. The calories of the milk occupied over 50% of the total calories. Primary outcome measures included usefulness of the milk, tolerability, caretakers' convenience and complications. Secondarily, seizure outcomes after diet therapy were evaluated. Results: All patients obtained normal weight and height gain and natural increase of bone densitometry index according to increasing ages. There were no serious complications. It was well tolerated in most 85.7% (24/28) of the patients and especially, convenience of its preparation was reported in all caretakers. 57.1% (16/28) of the patients showed a ≥90% reduction in seizure frequency. Most of the patients (85.7%) wanted to continue to use liquid ketogenic milk. Conclusion: We believe that the liquid ketogenic milk is useful formula to increase tolerability and widen application of the diet therapy in children with intractable epilepsy.

Original languageEnglish
Pages (from-to)e203-e207
Journale-SPEN
Volume5
Issue number5
DOIs
Publication statusPublished - 2010 Oct 1

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Milk
Diet Therapy
Seizures
Ketogenic Diet
Densitometry
Population Growth
Drug Resistant Epilepsy
Soybeans
Weight Gain
Outcome Assessment (Health Care)
Prospective Studies
Lipids
Bone and Bones

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism

Cite this

Lee, Yun Jin ; Kang, Hoon Chul ; Kim, Dong Wook ; Lee, Joon Soo ; Eun, Baik Lin ; Eun, So Hee ; You, Su Jeong ; Song, Ji Eun ; Lee, Eun Joo ; Kim, Heung Dong. / Usefulness of liquid ketogenic milk for intractable childhood epilepsy. In: e-SPEN. 2010 ; Vol. 5, No. 5. pp. e203-e207.
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abstract = "Background & aims: To evaluate the usefulness of a liquid ketogenic milk in the treatment of intractable childhood epilepsy. Methods: We used liquid ketogenic milk, which is comprised of mainly olive oil and soybeans, and has a lipid to non-lipid ratio of 4:1. Prospective study evaluated outcomes in 28 children with intractable epilepsy who were supplemented with liquid ketogenic milk for at least three months during conventional ketogenic diet. The calories of the milk occupied over 50{\%} of the total calories. Primary outcome measures included usefulness of the milk, tolerability, caretakers' convenience and complications. Secondarily, seizure outcomes after diet therapy were evaluated. Results: All patients obtained normal weight and height gain and natural increase of bone densitometry index according to increasing ages. There were no serious complications. It was well tolerated in most 85.7{\%} (24/28) of the patients and especially, convenience of its preparation was reported in all caretakers. 57.1{\%} (16/28) of the patients showed a ≥90{\%} reduction in seizure frequency. Most of the patients (85.7{\%}) wanted to continue to use liquid ketogenic milk. Conclusion: We believe that the liquid ketogenic milk is useful formula to increase tolerability and widen application of the diet therapy in children with intractable epilepsy.",
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Lee, YJ, Kang, HC, Kim, DW, Lee, JS, Eun, BL, Eun, SH, You, SJ, Song, JE, Lee, EJ & Kim, HD 2010, 'Usefulness of liquid ketogenic milk for intractable childhood epilepsy', e-SPEN, vol. 5, no. 5, pp. e203-e207. https://doi.org/10.1016/j.eclnm.2010.08.001

Usefulness of liquid ketogenic milk for intractable childhood epilepsy. / Lee, Yun Jin; Kang, Hoon Chul; Kim, Dong Wook; Lee, Joon Soo; Eun, Baik Lin; Eun, So Hee; You, Su Jeong; Song, Ji Eun; Lee, Eun Joo; Kim, Heung Dong.

In: e-SPEN, Vol. 5, No. 5, 01.10.2010, p. e203-e207.

Research output: Contribution to journalArticle

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AU - Lee, Yun Jin

AU - Kang, Hoon Chul

AU - Kim, Dong Wook

AU - Lee, Joon Soo

AU - Eun, Baik Lin

AU - Eun, So Hee

AU - You, Su Jeong

AU - Song, Ji Eun

AU - Lee, Eun Joo

AU - Kim, Heung Dong

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Y1 - 2010/10/1

N2 - Background & aims: To evaluate the usefulness of a liquid ketogenic milk in the treatment of intractable childhood epilepsy. Methods: We used liquid ketogenic milk, which is comprised of mainly olive oil and soybeans, and has a lipid to non-lipid ratio of 4:1. Prospective study evaluated outcomes in 28 children with intractable epilepsy who were supplemented with liquid ketogenic milk for at least three months during conventional ketogenic diet. The calories of the milk occupied over 50% of the total calories. Primary outcome measures included usefulness of the milk, tolerability, caretakers' convenience and complications. Secondarily, seizure outcomes after diet therapy were evaluated. Results: All patients obtained normal weight and height gain and natural increase of bone densitometry index according to increasing ages. There were no serious complications. It was well tolerated in most 85.7% (24/28) of the patients and especially, convenience of its preparation was reported in all caretakers. 57.1% (16/28) of the patients showed a ≥90% reduction in seizure frequency. Most of the patients (85.7%) wanted to continue to use liquid ketogenic milk. Conclusion: We believe that the liquid ketogenic milk is useful formula to increase tolerability and widen application of the diet therapy in children with intractable epilepsy.

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