Usefulness of serum leucine-rich alpha-2 glycoprotein as a disease activity biomarker in patients with rheumatoid arthritis

You Jung Ha, Eun Jin Kang, Sang Won Lee, Soo Kon Lee, Yong Beom Park, Jung Soo Song, Sang Tae Choi

Research output: Contribution to journalArticle

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Abstract

Our study aimed to investigate whether serum leucine-rich alpha-2-glycoprotein (LRG) levels are elevated in patients with rheumatoid arthritis (RA). In addition, we assessed their correlation with disease activity parameters and pro-inflammatory cytokine, tumor necrosis factor-α (TNF-α). Our study included 69 patients with RA and 48 age- and sexmatched healthy controls. Serum concentrations of TNF-α and LRG were determined by enzyme-linked immunosorbent assay. Serum LRG concentrations were significantly elevated in patients with RA compared with those in healthy controls (30.8 ± 14.4 vs. 22.2 ± 6.1 ng/mL; P < 0.001). In patients with RA, serum LRG levels were found to be correlated with disease activity score 28 (DAS28), erythrocyte sedimentation rate, and C-reactive protein levels (γ = 0.671; γ = 0.612; and γ = 0.601, P < 0.001, respectively), but not with serum TNF-α levels. Serum LRG levels in patients with an active disease status (DAS28 ≥ 2.6) were significantly higher than those in remission (DAS28 < 2.6) (36.45 ± 14.36 vs. 24.63 ± 8.81 ng/mL; P < 0.001). Our findings suggest that serum LRG could contribute to the inflammatory process independent of TNF-α and it may be a novel biomarker for assessing inflammatory activity in patients with RA.

Original languageEnglish
Pages (from-to)1199-1204
Number of pages6
JournalJournal of Korean medical science
Volume29
Issue number9
DOIs
Publication statusPublished - 2014 Jan 1

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Leucine
Rheumatoid Arthritis
Glycoproteins
Biomarkers
Serum
Tumor Necrosis Factor-alpha
Blood Sedimentation
C-Reactive Protein
Enzyme-Linked Immunosorbent Assay
Cytokines

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Ha, You Jung ; Kang, Eun Jin ; Lee, Sang Won ; Lee, Soo Kon ; Park, Yong Beom ; Song, Jung Soo ; Choi, Sang Tae. / Usefulness of serum leucine-rich alpha-2 glycoprotein as a disease activity biomarker in patients with rheumatoid arthritis. In: Journal of Korean medical science. 2014 ; Vol. 29, No. 9. pp. 1199-1204.
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abstract = "Our study aimed to investigate whether serum leucine-rich alpha-2-glycoprotein (LRG) levels are elevated in patients with rheumatoid arthritis (RA). In addition, we assessed their correlation with disease activity parameters and pro-inflammatory cytokine, tumor necrosis factor-α (TNF-α). Our study included 69 patients with RA and 48 age- and sexmatched healthy controls. Serum concentrations of TNF-α and LRG were determined by enzyme-linked immunosorbent assay. Serum LRG concentrations were significantly elevated in patients with RA compared with those in healthy controls (30.8 ± 14.4 vs. 22.2 ± 6.1 ng/mL; P < 0.001). In patients with RA, serum LRG levels were found to be correlated with disease activity score 28 (DAS28), erythrocyte sedimentation rate, and C-reactive protein levels (γ = 0.671; γ = 0.612; and γ = 0.601, P < 0.001, respectively), but not with serum TNF-α levels. Serum LRG levels in patients with an active disease status (DAS28 ≥ 2.6) were significantly higher than those in remission (DAS28 < 2.6) (36.45 ± 14.36 vs. 24.63 ± 8.81 ng/mL; P < 0.001). Our findings suggest that serum LRG could contribute to the inflammatory process independent of TNF-α and it may be a novel biomarker for assessing inflammatory activity in patients with RA.",
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Usefulness of serum leucine-rich alpha-2 glycoprotein as a disease activity biomarker in patients with rheumatoid arthritis. / Ha, You Jung; Kang, Eun Jin; Lee, Sang Won; Lee, Soo Kon; Park, Yong Beom; Song, Jung Soo; Choi, Sang Tae.

In: Journal of Korean medical science, Vol. 29, No. 9, 01.01.2014, p. 1199-1204.

Research output: Contribution to journalArticle

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