Using proteomics to identify targets of antiendothelial cell antibodies

Research output: Contribution to journalReview article

Abstract

Antiendothelial cell antibodies represent a heterogeneous group of antibodies directed against a variety of antigen determinants of endothelial cells. Antibodies reacting with endothelial structures have been detected in sera from patients with autoimmune vasculitis, both primary and secondary to systemic connective tissue diseases. It may interfere with several functions and, therefore, may be a pathophysiological relevance. The analysis of the antigens recognized by antiendothelial cell antibodies showed that the antibodies are directed against a heterogeneous family of both constitutive and nonconstitutive surface endothelial proteins. Proteomics is a field of science that evaluates a large number of proteins expressed from a given cell line or organism. The technology of proteomics has been used as a method for discovering the target protein specific to a particular disease by searching for the expression or modification of the protein. Recently, progress has been made in defining the target antigens of these antibodies and proteomic technologies is one of them. This review will focus on the proteomic technologies in searching autoantigens/ autoantibodies associated with disease of the endothelium.

Original languageEnglish
Pages (from-to)983-991
Number of pages9
JournalExpert Review of Clinical Immunology
Volume3
Issue number6
DOIs
Publication statusPublished - 2007 Nov 1

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Proteomics
Antibodies
Technology
Antigens
Proteins
Connective Tissue Diseases
Autoantigens
Vasculitis
Autoantibodies
Endothelium
Membrane Proteins
Endothelial Cells
Cell Line
anti-endothelial cell antibody
Serum

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

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abstract = "Antiendothelial cell antibodies represent a heterogeneous group of antibodies directed against a variety of antigen determinants of endothelial cells. Antibodies reacting with endothelial structures have been detected in sera from patients with autoimmune vasculitis, both primary and secondary to systemic connective tissue diseases. It may interfere with several functions and, therefore, may be a pathophysiological relevance. The analysis of the antigens recognized by antiendothelial cell antibodies showed that the antibodies are directed against a heterogeneous family of both constitutive and nonconstitutive surface endothelial proteins. Proteomics is a field of science that evaluates a large number of proteins expressed from a given cell line or organism. The technology of proteomics has been used as a method for discovering the target protein specific to a particular disease by searching for the expression or modification of the protein. Recently, progress has been made in defining the target antigens of these antibodies and proteomic technologies is one of them. This review will focus on the proteomic technologies in searching autoantigens/ autoantibodies associated with disease of the endothelium.",
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Using proteomics to identify targets of antiendothelial cell antibodies. / Lee, Ju Hee; Roh, Mi Ryung; Bang, Dongsik; Lee, Kwang Hoon.

In: Expert Review of Clinical Immunology, Vol. 3, No. 6, 01.11.2007, p. 983-991.

Research output: Contribution to journalReview article

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