Using transient elastography to predict hepatocellular carcinoma recurrence after radiofrequency ablation

Yu Rim Lee; Soo Young Park; Seung Up Kim; Se Young Jang; Won Young Tak; Young Oh Kweon; Beom Kyung Kim; Jun Yong Park; Do Young Kim; Sang Hoon Ahn; Kwang Hyub Han; Keun Hur

doi:10.1111/jgh.13644

Using transient elastography to predict hepatocellular carcinoma recurrence after radiofrequency ablation

Yu Rim Lee, Soo Young Park, Seung Up Kim, Se Young Jang, Won Young Tak, Young Oh Kweon, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang Hyub Han, Keun Hur

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

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Abstract

Background and Aim: Liver stiffness (LS) value determined using transient elastography (TE) can be used to assess the degree of liver fibrosis. The study investigated whether TE can predict the recurrence of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA). Methods: This study retrospectively enrolled 228 patients with HCC who received TE and RFA as the first-line treatment for HCC between 2008 and 2015. Cox regression analysis was used to identify independent predictors of HCC recurrence. Results: The median age of the study population (170 men and 58 women) was 61 years. During the study period, HCC recurrence and mortality developed in 125 (54.8%) and 37 (16.2%) patients after RFA, respectively. Liver cirrhosis, platelet count, multiple tumors, and LS value were the independent predictors of HCC recurrence. When the study population was stratified into early (< 12 months) and late (≥ 12 months) recurrence groups, LS value was an independent predictor of late recurrence, along with liver cirrhosis and spleen diameter. The risk of late recurrence was higher in patients with LS values of ≥ 13 kPa than in those with LS values of < 13 kPa (adjusted hazard ratio [HR] = 4.507, 95% confidence interval [CI] 2.131–7.724, P < 0.001). Recurrence was the only predictor of overall survival (HR = 18.583, 95% CI 2.424–142.486, P = 0.005). Conclusions: Findings of this study suggest that LS measurement using TE can be a useful predictor of HCC recurrence after RFA.

Original language	English
Pages (from-to)	1079-1086
Number of pages	8
Journal	Journal of Gastroenterology and Hepatology (Australia)
Volume	32
Issue number	5
DOIs	https://doi.org/10.1111/jgh.13644
Publication status	Published - 2017 May

Bibliographical note

Funding Information:
The authors are grateful to Dong-Su Jang (Medical Illustrator, Medical Research Support Section, Yonsei University College of Medicine, Seoul, South Korea) for his help with producing the figures. This study was supported by Kyungpook National University Research Fund, 2012, and the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning (2016R1A1A1A05005138). The funders had no role in the study design, data collection, and analysis, decision to publish, or preparation of the manuscript.

All Science Journal Classification (ASJC) codes

Hepatology
Gastroenterology

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Lee, Yu Rim ; Park, Soo Young ; Kim, Seung Up ; Jang, Se Young ; Tak, Won Young ; Kweon, Young Oh ; Kim, Beom Kyung ; Park, Jun Yong ; Kim, Do Young ; Ahn, Sang Hoon ; Han, Kwang Hyub ; Hur, Keun. / Using transient elastography to predict hepatocellular carcinoma recurrence after radiofrequency ablation. In: Journal of Gastroenterology and Hepatology (Australia). 2017 ; Vol. 32, No. 5. pp. 1079-1086.

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title = "Using transient elastography to predict hepatocellular carcinoma recurrence after radiofrequency ablation",

abstract = "Background and Aim: Liver stiffness (LS) value determined using transient elastography (TE) can be used to assess the degree of liver fibrosis. The study investigated whether TE can predict the recurrence of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA). Methods: This study retrospectively enrolled 228 patients with HCC who received TE and RFA as the first-line treatment for HCC between 2008 and 2015. Cox regression analysis was used to identify independent predictors of HCC recurrence. Results: The median age of the study population (170 men and 58 women) was 61 years. During the study period, HCC recurrence and mortality developed in 125 (54.8%) and 37 (16.2%) patients after RFA, respectively. Liver cirrhosis, platelet count, multiple tumors, and LS value were the independent predictors of HCC recurrence. When the study population was stratified into early (< 12 months) and late (≥ 12 months) recurrence groups, LS value was an independent predictor of late recurrence, along with liver cirrhosis and spleen diameter. The risk of late recurrence was higher in patients with LS values of ≥ 13 kPa than in those with LS values of < 13 kPa (adjusted hazard ratio [HR] = 4.507, 95% confidence interval [CI] 2.131–7.724, P < 0.001). Recurrence was the only predictor of overall survival (HR = 18.583, 95% CI 2.424–142.486, P = 0.005). Conclusions: Findings of this study suggest that LS measurement using TE can be a useful predictor of HCC recurrence after RFA.",

author = "Lee, {Yu Rim} and Park, {Soo Young} and Kim, {Seung Up} and Jang, {Se Young} and Tak, {Won Young} and Kweon, {Young Oh} and Kim, {Beom Kyung} and Park, {Jun Yong} and Kim, {Do Young} and Ahn, {Sang Hoon} and Han, {Kwang Hyub} and Keun Hur",

note = "Funding Information: The authors are grateful to Dong-Su Jang (Medical Illustrator, Medical Research Support Section, Yonsei University College of Medicine, Seoul, South Korea) for his help with producing the figures. This study was supported by Kyungpook National University Research Fund, 2012, and the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning (2016R1A1A1A05005138). The funders had no role in the study design, data collection, and analysis, decision to publish, or preparation of the manuscript.",

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Using transient elastography to predict hepatocellular carcinoma recurrence after radiofrequency ablation. / Lee, Yu Rim; Park, Soo Young; Kim, Seung Up; Jang, Se Young; Tak, Won Young; Kweon, Young Oh; Kim, Beom Kyung; Park, Jun Yong ; Kim, Do Young ; Ahn, Sang Hoon ; Han, Kwang Hyub; Hur, Keun.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 32, No. 5, 05.2017, p. 1079-1086.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Using transient elastography to predict hepatocellular carcinoma recurrence after radiofrequency ablation

AU - Lee, Yu Rim

AU - Park, Soo Young

AU - Kim, Seung Up

AU - Jang, Se Young

AU - Tak, Won Young

AU - Kweon, Young Oh

AU - Kim, Beom Kyung

AU - Park, Jun Yong

AU - Kim, Do Young

AU - Ahn, Sang Hoon

AU - Han, Kwang Hyub

AU - Hur, Keun

N1 - Funding Information: The authors are grateful to Dong-Su Jang (Medical Illustrator, Medical Research Support Section, Yonsei University College of Medicine, Seoul, South Korea) for his help with producing the figures. This study was supported by Kyungpook National University Research Fund, 2012, and the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning (2016R1A1A1A05005138). The funders had no role in the study design, data collection, and analysis, decision to publish, or preparation of the manuscript.

PY - 2017/5

Y1 - 2017/5

N2 - Background and Aim: Liver stiffness (LS) value determined using transient elastography (TE) can be used to assess the degree of liver fibrosis. The study investigated whether TE can predict the recurrence of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA). Methods: This study retrospectively enrolled 228 patients with HCC who received TE and RFA as the first-line treatment for HCC between 2008 and 2015. Cox regression analysis was used to identify independent predictors of HCC recurrence. Results: The median age of the study population (170 men and 58 women) was 61 years. During the study period, HCC recurrence and mortality developed in 125 (54.8%) and 37 (16.2%) patients after RFA, respectively. Liver cirrhosis, platelet count, multiple tumors, and LS value were the independent predictors of HCC recurrence. When the study population was stratified into early (< 12 months) and late (≥ 12 months) recurrence groups, LS value was an independent predictor of late recurrence, along with liver cirrhosis and spleen diameter. The risk of late recurrence was higher in patients with LS values of ≥ 13 kPa than in those with LS values of < 13 kPa (adjusted hazard ratio [HR] = 4.507, 95% confidence interval [CI] 2.131–7.724, P < 0.001). Recurrence was the only predictor of overall survival (HR = 18.583, 95% CI 2.424–142.486, P = 0.005). Conclusions: Findings of this study suggest that LS measurement using TE can be a useful predictor of HCC recurrence after RFA.

AB - Background and Aim: Liver stiffness (LS) value determined using transient elastography (TE) can be used to assess the degree of liver fibrosis. The study investigated whether TE can predict the recurrence of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA). Methods: This study retrospectively enrolled 228 patients with HCC who received TE and RFA as the first-line treatment for HCC between 2008 and 2015. Cox regression analysis was used to identify independent predictors of HCC recurrence. Results: The median age of the study population (170 men and 58 women) was 61 years. During the study period, HCC recurrence and mortality developed in 125 (54.8%) and 37 (16.2%) patients after RFA, respectively. Liver cirrhosis, platelet count, multiple tumors, and LS value were the independent predictors of HCC recurrence. When the study population was stratified into early (< 12 months) and late (≥ 12 months) recurrence groups, LS value was an independent predictor of late recurrence, along with liver cirrhosis and spleen diameter. The risk of late recurrence was higher in patients with LS values of ≥ 13 kPa than in those with LS values of < 13 kPa (adjusted hazard ratio [HR] = 4.507, 95% confidence interval [CI] 2.131–7.724, P < 0.001). Recurrence was the only predictor of overall survival (HR = 18.583, 95% CI 2.424–142.486, P = 0.005). Conclusions: Findings of this study suggest that LS measurement using TE can be a useful predictor of HCC recurrence after RFA.

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