USP11: A key regulator of cIAP2 stability and sensitivity to SMAC mimetics

Eun Woo Lee; Jaewhan Song

doi:10.1080/23723556.2015.1029829

USP11: A key regulator of cIAP2 stability and sensitivity to SMAC mimetics

Eun Woo Lee, Jaewhan Song

Research output: Contribution to journal › Article

4 Citations (Scopus)

Abstract

The critical function of cellular inhibitor of apoptosis proteins (cIAPs) in the protection of cancer cells from numerous apoptotic stimuli prompted the development of second mitochondria-derived activator of caspases (SMAC) mimetics. We recently addressed a novel survival pathway in which cIAP2 is induced by tumor necrosis factor-α and is stabilized by its specific deubiquitylase, USP11, rendering cells resistant to SMAC mimetics.

Original language	English
Article number	e1029829
Journal	Molecular and Cellular Oncology
Volume	3
Issue number	3
DOIs	https://doi.org/10.1080/23723556.2015.1029829
Publication status	Published - 2016 May 3

All Science Journal Classification (ASJC) codes

Molecular Medicine
Cancer Research

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Lee, E. W., & Song, J. (2016). USP11: A key regulator of cIAP2 stability and sensitivity to SMAC mimetics. Molecular and Cellular Oncology, 3(3), [e1029829]. https://doi.org/10.1080/23723556.2015.1029829

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