USP11: A key regulator of cIAP2 stability and sensitivity to SMAC mimetics

Eun Woo Lee, Jaewhan Song

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


The critical function of cellular inhibitor of apoptosis proteins (cIAPs) in the protection of cancer cells from numerous apoptotic stimuli prompted the development of second mitochondria-derived activator of caspases (SMAC) mimetics. We recently addressed a novel survival pathway in which cIAP2 is induced by tumor necrosis factor-α and is stabilized by its specific deubiquitylase, USP11, rendering cells resistant to SMAC mimetics.

Original languageEnglish
Article numbere1029829
JournalMolecular and Cellular Oncology
Issue number3
Publication statusPublished - 2016 May 3

Bibliographical note

Funding Information:
This research was supported by a grant from the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2012R1A6A3A04040105) (E.W.L) and by the Ministry of Science, ICT and Future Planning (NRF- 2015R1A3A2066581) (to J.Song).

Publisher Copyright:
© 2016, © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2016, © Eun-Woo Lee and Jaewhan Song.

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Cancer Research


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