Abstract
The critical function of cellular inhibitor of apoptosis proteins (cIAPs) in the protection of cancer cells from numerous apoptotic stimuli prompted the development of second mitochondria-derived activator of caspases (SMAC) mimetics. We recently addressed a novel survival pathway in which cIAP2 is induced by tumor necrosis factor-α and is stabilized by its specific deubiquitylase, USP11, rendering cells resistant to SMAC mimetics.
| Original language | English |
|---|---|
| Article number | e1029829 |
| Journal | Molecular and Cellular Oncology |
| Volume | 3 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2016 May 3 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Cancer Research
Cite this
}
USP11 : A key regulator of cIAP2 stability and sensitivity to SMAC mimetics. / Lee, Eun Woo; Song, Jaewhan.
In: Molecular and Cellular Oncology, Vol. 3, No. 3, e1029829, 03.05.2016.Research output: Contribution to journal › Article
TY - JOUR
T1 - USP11
T2 - A key regulator of cIAP2 stability and sensitivity to SMAC mimetics
AU - Lee, Eun Woo
AU - Song, Jaewhan
PY - 2016/5/3
Y1 - 2016/5/3
N2 - The critical function of cellular inhibitor of apoptosis proteins (cIAPs) in the protection of cancer cells from numerous apoptotic stimuli prompted the development of second mitochondria-derived activator of caspases (SMAC) mimetics. We recently addressed a novel survival pathway in which cIAP2 is induced by tumor necrosis factor-α and is stabilized by its specific deubiquitylase, USP11, rendering cells resistant to SMAC mimetics.
AB - The critical function of cellular inhibitor of apoptosis proteins (cIAPs) in the protection of cancer cells from numerous apoptotic stimuli prompted the development of second mitochondria-derived activator of caspases (SMAC) mimetics. We recently addressed a novel survival pathway in which cIAP2 is induced by tumor necrosis factor-α and is stabilized by its specific deubiquitylase, USP11, rendering cells resistant to SMAC mimetics.
UR - http://www.scopus.com/inward/record.url?scp=85033784094&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85033784094&partnerID=8YFLogxK
U2 - 10.1080/23723556.2015.1029829
DO - 10.1080/23723556.2015.1029829
M3 - Article
AN - SCOPUS:85033784094
VL - 3
JO - Molecular and Cellular Oncology
JF - Molecular and Cellular Oncology
SN - 2372-3556
IS - 3
M1 - e1029829
ER -