USP11: A key regulator of cIAP2 stability and sensitivity to SMAC mimetics

Eun Woo Lee, Jaewhan Song

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

The critical function of cellular inhibitor of apoptosis proteins (cIAPs) in the protection of cancer cells from numerous apoptotic stimuli prompted the development of second mitochondria-derived activator of caspases (SMAC) mimetics. We recently addressed a novel survival pathway in which cIAP2 is induced by tumor necrosis factor-α and is stabilized by its specific deubiquitylase, USP11, rendering cells resistant to SMAC mimetics.

Original languageEnglish
Article numbere1029829
JournalMolecular and Cellular Oncology
Volume3
Issue number3
DOIs
Publication statusPublished - 2016 May 3

Bibliographical note

Funding Information:
This research was supported by a grant from the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2012R1A6A3A04040105) (E.W.L) and by the Ministry of Science, ICT and Future Planning (NRF- 2015R1A3A2066581) (to J.Song).

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Cancer Research

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