USP11: A key regulator of cIAP2 stability and sensitivity to SMAC mimetics

Eun Woo Lee, Jaewhan Song

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The critical function of cellular inhibitor of apoptosis proteins (cIAPs) in the protection of cancer cells from numerous apoptotic stimuli prompted the development of second mitochondria-derived activator of caspases (SMAC) mimetics. We recently addressed a novel survival pathway in which cIAP2 is induced by tumor necrosis factor-α and is stabilized by its specific deubiquitylase, USP11, rendering cells resistant to SMAC mimetics.

Original languageEnglish
Article numbere1029829
JournalMolecular and Cellular Oncology
Volume3
Issue number3
DOIs
Publication statusPublished - 2016 May 3

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Cancer Research

Cite this