USP11: A key regulator of cIAP2 stability and sensitivity to SMAC mimetics

Eun Woo Lee, Jaewhan Song

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The critical function of cellular inhibitor of apoptosis proteins (cIAPs) in the protection of cancer cells from numerous apoptotic stimuli prompted the development of second mitochondria-derived activator of caspases (SMAC) mimetics. We recently addressed a novel survival pathway in which cIAP2 is induced by tumor necrosis factor-α and is stabilized by its specific deubiquitylase, USP11, rendering cells resistant to SMAC mimetics.

Original languageEnglish
Article numbere1029829
JournalMolecular and Cellular Oncology
Volume3
Issue number3
DOIs
Publication statusPublished - 2016 May 3

Fingerprint

Caspases
Mitochondria
Inhibitor of Apoptosis Proteins
Cytoprotection
Tumor Necrosis Factor-alpha
Neoplasms

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Cancer Research

Cite this

@article{52233a96bf9248b48f35b1da2c988009,
title = "USP11: A key regulator of cIAP2 stability and sensitivity to SMAC mimetics",
abstract = "The critical function of cellular inhibitor of apoptosis proteins (cIAPs) in the protection of cancer cells from numerous apoptotic stimuli prompted the development of second mitochondria-derived activator of caspases (SMAC) mimetics. We recently addressed a novel survival pathway in which cIAP2 is induced by tumor necrosis factor-α and is stabilized by its specific deubiquitylase, USP11, rendering cells resistant to SMAC mimetics.",
author = "Lee, {Eun Woo} and Jaewhan Song",
year = "2016",
month = "5",
day = "3",
doi = "10.1080/23723556.2015.1029829",
language = "English",
volume = "3",
journal = "Molecular and Cellular Oncology",
issn = "2372-3556",
publisher = "Taylor and Francis Ltd.",
number = "3",

}

USP11 : A key regulator of cIAP2 stability and sensitivity to SMAC mimetics. / Lee, Eun Woo; Song, Jaewhan.

In: Molecular and Cellular Oncology, Vol. 3, No. 3, e1029829, 03.05.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - USP11

T2 - A key regulator of cIAP2 stability and sensitivity to SMAC mimetics

AU - Lee, Eun Woo

AU - Song, Jaewhan

PY - 2016/5/3

Y1 - 2016/5/3

N2 - The critical function of cellular inhibitor of apoptosis proteins (cIAPs) in the protection of cancer cells from numerous apoptotic stimuli prompted the development of second mitochondria-derived activator of caspases (SMAC) mimetics. We recently addressed a novel survival pathway in which cIAP2 is induced by tumor necrosis factor-α and is stabilized by its specific deubiquitylase, USP11, rendering cells resistant to SMAC mimetics.

AB - The critical function of cellular inhibitor of apoptosis proteins (cIAPs) in the protection of cancer cells from numerous apoptotic stimuli prompted the development of second mitochondria-derived activator of caspases (SMAC) mimetics. We recently addressed a novel survival pathway in which cIAP2 is induced by tumor necrosis factor-α and is stabilized by its specific deubiquitylase, USP11, rendering cells resistant to SMAC mimetics.

UR - http://www.scopus.com/inward/record.url?scp=85033784094&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85033784094&partnerID=8YFLogxK

U2 - 10.1080/23723556.2015.1029829

DO - 10.1080/23723556.2015.1029829

M3 - Article

AN - SCOPUS:85033784094

VL - 3

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

SN - 2372-3556

IS - 3

M1 - e1029829

ER -