The critical function of cellular inhibitor of apoptosis proteins (cIAPs) in the protection of cancer cells from numerous apoptotic stimuli prompted the development of second mitochondria-derived activator of caspases (SMAC) mimetics. We recently addressed a novel survival pathway in which cIAP2 is induced by tumor necrosis factor-α and is stabilized by its specific deubiquitylase, USP11, rendering cells resistant to SMAC mimetics.
Bibliographical noteFunding Information:
This research was supported by a grant from the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2012R1A6A3A04040105) (E.W.L) and by the Ministry of Science, ICT and Future Planning (NRF- 2015R1A3A2066581) (to J.Song).
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Cancer Research