USP11: A key regulator of cIAP2 stability and sensitivity to SMAC mimetics

Eun Woo Lee, Jaewhan Song

Research output: Contribution to journalArticle

4 Citations (Scopus)


The critical function of cellular inhibitor of apoptosis proteins (cIAPs) in the protection of cancer cells from numerous apoptotic stimuli prompted the development of second mitochondria-derived activator of caspases (SMAC) mimetics. We recently addressed a novel survival pathway in which cIAP2 is induced by tumor necrosis factor-α and is stabilized by its specific deubiquitylase, USP11, rendering cells resistant to SMAC mimetics.

Original languageEnglish
Article numbere1029829
JournalMolecular and Cellular Oncology
Issue number3
Publication statusPublished - 2016 May 3


All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Cancer Research

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