Utility of routine culture for tuberculosis from endobronchial ultrasound-guided transbronchial needle aspiration in a tuberculosis endemic country

Ji Young Hong, Ji Ye Jung, youngae kang, Byung Hoon Park, Won Jai Jung, Su Hwan Lee, Song Yee Kim, Sang Kook Lee, Kyung Soo Chung, Seon Cheol Park, Eun Young Kim, Ju Eun Lim, Se Kyu Kim, Joon Chang, Young Sam Kim

Research output: Contribution to journalArticle

Abstract

Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a technique developed to allow mediastinal staging of lung cancer and also to evaluate intrathoracic lymphadenopathy. In a tuberculosis-endemic area, tuberculosis should be considered as an etiology of mediastinal lymphadenopathy. The aim of this study was to investigate the utility of the routine culture for tuberculosis from specimens of EBUS-TBNA. Methods: We prospectively performed routine culture for tuberculosis from aspiration or core biopsy specimens got from 86 patients who had undergone EBUS-TBNA due to mediastinal lymphadenopathy between March 2010 and March 2011. Results: A total of 135 lymph node aspiration and 118 core biopsy specimens were included in this analysis. We confirmed the malignancy in 62 (72.9%), tuberculosis in 7 (8.1%), sarcoidosis in 7 (8.1%), asperogillosis in 2 (2.3%) and pneumoconiosis in 2 (2.3%) patients. One lung cancer patient had pulmonary tuberculosis coincidentally and 5 patients had unknown lymphadenopathy. The number of positive culture for Mycobacterium tuberculsosis by EBUS-TBNA is 2 (1.5%) from 135 lymph node aspiration specimens and 2 (1.7%) from 118 core biopsy specimens. Out of eight patients confirmed with tuberculosis, only one patient had positive mycobacterial culture of aspiration specimen from EBUS-TBNA without histopathologic diagnosis. Conclusion: These results propose that routine culture for tuberculosis from EBUS-TBNA may not provide additional information for the diagnosis of coincident tuberculous lymphadenitis. However, if there is any possibility of tuberculous lymphadenopathy or pulmonary tuberculosis, it should be considered to perform EBUS-TBNA in patients who have negative sputum AFB smears or no sputum production. Copyright

Original languageEnglish
Pages (from-to)408-416
Number of pages9
JournalTuberculosis and Respiratory Diseases
Volume71
Issue number6
DOIs
Publication statusPublished - 2011 Dec 30

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Needles
Tuberculosis
Sputum
Biopsy
Pulmonary Tuberculosis
Lung Neoplasms
Lymph Nodes
Lymph Node Tuberculosis
Pneumoconiosis
Mycobacterium
Sarcoidosis
Lymphadenopathy
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Hong, Ji Young ; Jung, Ji Ye ; kang, youngae ; Park, Byung Hoon ; Jung, Won Jai ; Lee, Su Hwan ; Kim, Song Yee ; Lee, Sang Kook ; Chung, Kyung Soo ; Park, Seon Cheol ; Kim, Eun Young ; Lim, Ju Eun ; Kim, Se Kyu ; Chang, Joon ; Kim, Young Sam. / Utility of routine culture for tuberculosis from endobronchial ultrasound-guided transbronchial needle aspiration in a tuberculosis endemic country. In: Tuberculosis and Respiratory Diseases. 2011 ; Vol. 71, No. 6. pp. 408-416.
@article{058c371dbb49478998277514fcd25034,
title = "Utility of routine culture for tuberculosis from endobronchial ultrasound-guided transbronchial needle aspiration in a tuberculosis endemic country",
abstract = "Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a technique developed to allow mediastinal staging of lung cancer and also to evaluate intrathoracic lymphadenopathy. In a tuberculosis-endemic area, tuberculosis should be considered as an etiology of mediastinal lymphadenopathy. The aim of this study was to investigate the utility of the routine culture for tuberculosis from specimens of EBUS-TBNA. Methods: We prospectively performed routine culture for tuberculosis from aspiration or core biopsy specimens got from 86 patients who had undergone EBUS-TBNA due to mediastinal lymphadenopathy between March 2010 and March 2011. Results: A total of 135 lymph node aspiration and 118 core biopsy specimens were included in this analysis. We confirmed the malignancy in 62 (72.9{\%}), tuberculosis in 7 (8.1{\%}), sarcoidosis in 7 (8.1{\%}), asperogillosis in 2 (2.3{\%}) and pneumoconiosis in 2 (2.3{\%}) patients. One lung cancer patient had pulmonary tuberculosis coincidentally and 5 patients had unknown lymphadenopathy. The number of positive culture for Mycobacterium tuberculsosis by EBUS-TBNA is 2 (1.5{\%}) from 135 lymph node aspiration specimens and 2 (1.7{\%}) from 118 core biopsy specimens. Out of eight patients confirmed with tuberculosis, only one patient had positive mycobacterial culture of aspiration specimen from EBUS-TBNA without histopathologic diagnosis. Conclusion: These results propose that routine culture for tuberculosis from EBUS-TBNA may not provide additional information for the diagnosis of coincident tuberculous lymphadenitis. However, if there is any possibility of tuberculous lymphadenopathy or pulmonary tuberculosis, it should be considered to perform EBUS-TBNA in patients who have negative sputum AFB smears or no sputum production. Copyright",
author = "Hong, {Ji Young} and Jung, {Ji Ye} and youngae kang and Park, {Byung Hoon} and Jung, {Won Jai} and Lee, {Su Hwan} and Kim, {Song Yee} and Lee, {Sang Kook} and Chung, {Kyung Soo} and Park, {Seon Cheol} and Kim, {Eun Young} and Lim, {Ju Eun} and Kim, {Se Kyu} and Joon Chang and Kim, {Young Sam}",
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Hong, JY, Jung, JY, kang, Y, Park, BH, Jung, WJ, Lee, SH, Kim, SY, Lee, SK, Chung, KS, Park, SC, Kim, EY, Lim, JE, Kim, SK, Chang, J & Kim, YS 2011, 'Utility of routine culture for tuberculosis from endobronchial ultrasound-guided transbronchial needle aspiration in a tuberculosis endemic country', Tuberculosis and Respiratory Diseases, vol. 71, no. 6, pp. 408-416. https://doi.org/10.4046/trd.2011.71.6.408

Utility of routine culture for tuberculosis from endobronchial ultrasound-guided transbronchial needle aspiration in a tuberculosis endemic country. / Hong, Ji Young; Jung, Ji Ye; kang, youngae; Park, Byung Hoon; Jung, Won Jai; Lee, Su Hwan; Kim, Song Yee; Lee, Sang Kook; Chung, Kyung Soo; Park, Seon Cheol; Kim, Eun Young; Lim, Ju Eun; Kim, Se Kyu; Chang, Joon; Kim, Young Sam.

In: Tuberculosis and Respiratory Diseases, Vol. 71, No. 6, 30.12.2011, p. 408-416.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Utility of routine culture for tuberculosis from endobronchial ultrasound-guided transbronchial needle aspiration in a tuberculosis endemic country

AU - Hong, Ji Young

AU - Jung, Ji Ye

AU - kang, youngae

AU - Park, Byung Hoon

AU - Jung, Won Jai

AU - Lee, Su Hwan

AU - Kim, Song Yee

AU - Lee, Sang Kook

AU - Chung, Kyung Soo

AU - Park, Seon Cheol

AU - Kim, Eun Young

AU - Lim, Ju Eun

AU - Kim, Se Kyu

AU - Chang, Joon

AU - Kim, Young Sam

PY - 2011/12/30

Y1 - 2011/12/30

N2 - Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a technique developed to allow mediastinal staging of lung cancer and also to evaluate intrathoracic lymphadenopathy. In a tuberculosis-endemic area, tuberculosis should be considered as an etiology of mediastinal lymphadenopathy. The aim of this study was to investigate the utility of the routine culture for tuberculosis from specimens of EBUS-TBNA. Methods: We prospectively performed routine culture for tuberculosis from aspiration or core biopsy specimens got from 86 patients who had undergone EBUS-TBNA due to mediastinal lymphadenopathy between March 2010 and March 2011. Results: A total of 135 lymph node aspiration and 118 core biopsy specimens were included in this analysis. We confirmed the malignancy in 62 (72.9%), tuberculosis in 7 (8.1%), sarcoidosis in 7 (8.1%), asperogillosis in 2 (2.3%) and pneumoconiosis in 2 (2.3%) patients. One lung cancer patient had pulmonary tuberculosis coincidentally and 5 patients had unknown lymphadenopathy. The number of positive culture for Mycobacterium tuberculsosis by EBUS-TBNA is 2 (1.5%) from 135 lymph node aspiration specimens and 2 (1.7%) from 118 core biopsy specimens. Out of eight patients confirmed with tuberculosis, only one patient had positive mycobacterial culture of aspiration specimen from EBUS-TBNA without histopathologic diagnosis. Conclusion: These results propose that routine culture for tuberculosis from EBUS-TBNA may not provide additional information for the diagnosis of coincident tuberculous lymphadenitis. However, if there is any possibility of tuberculous lymphadenopathy or pulmonary tuberculosis, it should be considered to perform EBUS-TBNA in patients who have negative sputum AFB smears or no sputum production. Copyright

AB - Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a technique developed to allow mediastinal staging of lung cancer and also to evaluate intrathoracic lymphadenopathy. In a tuberculosis-endemic area, tuberculosis should be considered as an etiology of mediastinal lymphadenopathy. The aim of this study was to investigate the utility of the routine culture for tuberculosis from specimens of EBUS-TBNA. Methods: We prospectively performed routine culture for tuberculosis from aspiration or core biopsy specimens got from 86 patients who had undergone EBUS-TBNA due to mediastinal lymphadenopathy between March 2010 and March 2011. Results: A total of 135 lymph node aspiration and 118 core biopsy specimens were included in this analysis. We confirmed the malignancy in 62 (72.9%), tuberculosis in 7 (8.1%), sarcoidosis in 7 (8.1%), asperogillosis in 2 (2.3%) and pneumoconiosis in 2 (2.3%) patients. One lung cancer patient had pulmonary tuberculosis coincidentally and 5 patients had unknown lymphadenopathy. The number of positive culture for Mycobacterium tuberculsosis by EBUS-TBNA is 2 (1.5%) from 135 lymph node aspiration specimens and 2 (1.7%) from 118 core biopsy specimens. Out of eight patients confirmed with tuberculosis, only one patient had positive mycobacterial culture of aspiration specimen from EBUS-TBNA without histopathologic diagnosis. Conclusion: These results propose that routine culture for tuberculosis from EBUS-TBNA may not provide additional information for the diagnosis of coincident tuberculous lymphadenitis. However, if there is any possibility of tuberculous lymphadenopathy or pulmonary tuberculosis, it should be considered to perform EBUS-TBNA in patients who have negative sputum AFB smears or no sputum production. Copyright

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